A5016801105- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Immune cells in cancer
- SARS-CoV-2 and COVID-19 Research
- CRISPR and Genetic Engineering
- Influenza Virus Research Studies
- Plant tissue culture and regeneration
- Plant Disease Management Techniques
- Parasite Biology and Host Interactions
- Diabetes and associated disorders
- Oral microbiology and periodontitis research
- Agriculture, Plant Science, Crop Management
- Alcohol Consumption and Health Effects
- Immune Cell Function and Interaction
- Parasites and Host Interactions
- Research on Leishmaniasis Studies
- CAR-T cell therapy research
- Plant Virus Research Studies
- Neonatal Respiratory Health Research
- Biotechnology and Related Fields
- Helminth infection and control
- Plant Pathogens and Resistance
- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- Innovation and Socioeconomic Development
Universidade de São Paulo
2020-2025
Central Potato Research Institute
2012-2024
Hospital Israelita Albert Einstein
2022-2023
Abstract The pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS- CoV-2) has resulted in several thousand deaths worldwide just a few months. Patients who died from disease 2019 (COVID-19) often had comorbidities, such as hypertension, diabetes, and chronic obstructive lung disease. angiotensin-converting enzyme (ACE2) was identified crucial factor that facilitates SARS-CoV2 to bind enter host cells. To date, no study assessed ACE2 expression lungs of patients with...
Occurrence of hyperglycemia upon infection is associated with worse clinical outcome in COVID-19 patients. However, it still unknown whether SARS-CoV-2 directly triggers hyperglycemia. Herein, we interrogated and how causes by infecting hepatocytes increasing glucose production. We performed a retrospective cohort study including patients that were admitted at hospital suspicion COVID-19. Clinical laboratory data collected from the chart records daily blood values analyzed to test hypothesis...
Summary Background Cutaneous leishmaniasis (CL) is characterized by immune dysregulation that facilitates chronic infection. Objective To investigate the role of T cells in immunopathology CL characterizing landscape skin lesions using single-cell RNA sequencing (scRNA-seq). Methods We performed scRNA-seq to profile from PBMC and patients. Results analyzed transcriptional distinct populations CD4+ CD8+ migratory lesions. resident displayed expression exhaustion markers were categorized into...
Several perturbations in the number of peripheral blood leukocytes, such as neutrophilia and lymphopenia associated with Coronavirus disease 2019 (COVID-19) severity, point to systemic molecular cell cycle alterations during severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. However, landscape COVID-19 remains primarily unexplored. Here, we performed an integrative systems immunology analysis publicly available proteome transcriptome data characterize global changes...
Individuals exhibiting an intermediate alcohol drinking pattern in conjunction with signs of metabolic risk present clinical features both alcohol-associated and metabolic-associated fatty liver diseases. However, such combination remains unexplored area great interest, given the increasing number patients affected. In study, we aimed to develop a preclinical DUAL (alcohol-associated disease plus disease) model mice. C57BL/6 mice received 10% vol/vol sweetened water Western diet for 10, 23,...
Breastfeeding protects against mucosal infections in infants. The underlying mechanisms through which immunity develops human milk following maternal infection with pathogens are not well understood. We simulated nasal influenza live attenuated vaccination (LAIV) and compared immune responses to inactivated (IIV). Transcriptomic analysis was performed on RNA extracted from cells evaluate differentially expressed genes pathways days 1 7 post-vaccination. Both LAIV IIV vaccines induced...
In spite of several decades research, an effective vaccine against schistosomiasis remains elusive. The radiation-attenuated (RA) cercarial is still the best model eliciting high protection levels, although immune mechanisms have not yet been fully characterized. order to identify genes and pathways underlying we investigated patterns gene expression in PBMC skin draining Lymph Nodes (LN) from mice using two exposure comparisons: vaccination with 500 attenuated cercariae versus infection...
The present experiment was conducted during 2020–21, 2021–22 and 2022–23 at Regional Station, ICAR-Central Potato Research Institute, Gwalior, Madhya Pradesh to evaluate the best spacing combination dehaulming time for enhancing seed size potato (Solanum tuberosum L.) tubers profitability under north-central plains of India. Experiment in a split-plot design (SPD) comprised 5 combinations, viz. S1, Ridge furrow 60 cm × 20 (Control); S2, 15 cm; S3, Flatbed paired row 90 bed width (two rows 40...
A field experiment was conducted at ICAR- CPRI, Regional Station, Gwalior, Madhya Pradesh to study the effect of soil solarization on weed population and multiplication seed potatoes under aphid proof net house (Gen-0) subsequently conditions (Gen-1) 3 potato cultivars, viz. Kufri Mohan, Chipsona-1 Lauvkar during 2017-18 2018-19. Treatments were replicated thrice in split plot design. The experimental area solarized with black polythene paddy straw mulch, whereas, unsolarized plots served as...