A5109462875- Diabetes Treatment and Management
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Gestational Diabetes Research and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet and metabolism studies
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Pregnancy and preeclampsia studies
- Hormonal Regulation and Hypertension
- Birth, Development, and Health
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Adipose Tissue and Metabolism
- Cardiovascular Function and Risk Factors
- Chronic Kidney Disease and Diabetes
- Advanced Glycation End Products research
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Bariatric Surgery and Outcomes
- Diabetes Management and Education
- Medication Adherence and Compliance
- Natural Antidiabetic Agents Studies
- COVID-19 Clinical Research Studies
Universidade Federal do Paraná
2014-2025
Hospital de Clínicas Universidade Federal do Paraná
2014-2025
Oxford University Hospitals NHS Trust
2022
Oxford BioMedica (United Kingdom)
2019-2020
Leeds Teaching Hospitals NHS Trust
2020
Oxford Centre for Diabetes, Endocrinology and Metabolism
2019-2020
Surrey Memorial Hospital
2019
Novo Nordisk (Denmark)
2018
Hospital de Clínicas
2012-2017
Hospital de Clínicas de Porto Alegre
2014
Occurrence of hyperglycemia upon infection is associated with worse clinical outcome in COVID-19 patients. However, it still unknown whether SARS-CoV-2 directly triggers hyperglycemia. Herein, we interrogated and how causes by infecting hepatocytes increasing glucose production. We performed a retrospective cohort study including patients that were admitted at hospital suspicion COVID-19. Clinical laboratory data collected from the chart records daily blood values analyzed to test hypothesis...
To determine the relationship between adherence to diet reported by patients with type 1 diabetes under routine clinical care in Brazil, and demographic, socioeconomic status, glycemic control cardiovascular risk factors. This was a cross-sectional, multicenter study conducted December 2008 2010 28 public clinics 20 Brazilian cities. The data obtained from 3,180 patients, aged 22 ± 11.8 years (56.3% females, 57.4% Caucasians 43.6% non-Caucasians). mean time since diagnosis 11.7 8.1 years....
Letters19 March 2019Effect of Liraglutide on Cardiovascular Outcomes in Elderly Patients: A Post Hoc Analysis a Randomized Controlled TrialMatthew P. Gilbert, DO, MPH, Stephen C. Bain, MD, Edward Franek, PhD, Esteban Jodar-Gimeno, Michael A. Nauck, Richard Pratley, Rosângela Roginski Réa, José Francisco Kerr Saraiva, Søren Rasmussen, MSc, Karen Tornøe, Bernt Johan von Scholten, DMSc, and John B. Buse, MD the LEADER Publication Committee behalf Trial Investigators*Matthew MPHLarner College...
To compare the effect of liraglutide or placebo added on to sodium-glucose co-transporter-2 inhibitor (SGLT2i) ± metformin glycaemic control in patients with type 2 diabetes.Patients diabetes a stable SGLT2i dose (with HbA1c 7.0%-9.5% and body mass index [BMI] ≥ 20 kg/m2 ) were randomized 2:1 add-on 1.8 mg/day this parallel, double-blind, multinational trial. Primary confirmatory secondary endpoints changes weight from baseline week 26, respectively. The proportions achieving (<7.0%) targets...
COMBINE 2 assessed the efficacy and safety of once-weekly IcoSema (a combination therapy basal insulin icodec semaglutide) vs semaglutide glucagon-like peptide-1 analogue) 1.0 mg in individuals with type diabetes inadequately managed GLP-1 receptor agonist (GLP-1 RA) therapy, or without additional oral glucose-lowering medications. This 52 week, randomised, multicentre, open-label, parallel group, Phase IIIa trial was conducted across 121 sites 13 countries/regions. Adults (HbA1c 53.0-85.8...
OBJETIVO: Avaliar a prevalência de sobrepeso e obesidade em pacientes ambulatoriais com diabetes mellitus tipo 2 (DM2) diferentes regiões do Brasil. PACIENTES E MÉTODOS: Avaliamos aleatoriamente 2.519 11 hospitais, ambulatórios especializados um posto saúde 10 cidades brasileiras. Consideramos índice massa corporal (IMC) > 25 IMC 30 kg/m². O controle glicêmico (CG) foi avaliado pelo CG [ICG= HbA1 ou HbA1c paciente/limite superior normalidade método x 100]. RESULTADOS: Os tinham idade 58,8...
The Review of Diabetic Studies,2006,3,2,82-87.DOI:10.1900/RDS.2006.3.82Published:August 2006Type:Original ArticleAuthors:Marilia de Brito Gomes, Daniel Gianella, Manuel Faria, Marcos Tambascia, Reine Marie Fonseca, Rosangela Réa, Geísa Macedo, João Modesto Filho, Helena Schmid, Alcina Vinhaes Bittencourt, Saulo Cavalcanti, Nelson Rassi, Hermelinda Pedrosa, and Sérgio Atala Dib Author(s) affiliations:Marilia Gomes1, Gianella2, Faria3, Tambascia4, Fonseca5, Réa6, Macedo7, Filho8, Schmid9,...
To determine the characteristics of clinical care offered to type 1 diabetic patients across four distinct regions Brazil, with geographic and contrasting socioeconomic differences. Glycemic control, prevalence cardiovascular risk factors, screening for chronic complications frequency that recommended treatment goals were met using American Diabetes Association guidelines evaluated.This was a cross-sectional, multicenter study conducted from December 2008 2010 in 28 secondary tertiary public...
Chronic hyperglycemia, which is present in all types of diabetes, increases the formation advanced glycation end-products (AGEs). The interaction AGEs with receptor (RAGE) initiates a cascade pro-inflammatory and pro-coagulant processes that result oxidative stress, stimulating accumulation more AGE molecules. This cyclic process, denominated metabolic memory, may explain persistency diabetic vascular complications patients satisfactory glycemic control. RAGE found several cell membranes...
To assess what drives change in health-related quality of life (HRQoL) type 2 diabetes the SUSTAIN 6 trial and identify potential mediators treatment effect semaglutide on HRQoL scores.The Short Form (SF)-36v2® questionnaire [comprising physical component summary (PCS) mental (MCS)] was used to changes from baseline week 104, by treatment, a prespecified analysis. This post-hoc analysis assessed PCS MCS using following factors as parameter/covariate, descriptive statistics linear...
Abstract Total butyrylcholinesterase activity (EC 3.1.1.8) was previously suggested as a marker for metabolic syndrome. The present study examined total and the relative absolute activities of two electrophoretic bands (C
According to Brazilian National Data Survey diabetes is the fifth cause for hospitalization and one of ten major causes mortality in this country.to stratify estimated cardiovascular risk (eCVR) a population type 2 diabetics (T2DM) according Framingham prediction equations as well determine association between eCVR with metabolic clinical control disease.From 2000 2001 cross-sectional multicenter study was conducted 13 public out-patients diabetes/endocrinology clinics from 8 cities. The...
Dysglycemias have been associated with worse prognosis in critically ill patients COVID-19, but data on the association of dysglycemia COVID-19 comparison other forms severe acute respiratory syndrome are lacking. This study aimed to compare occurrence different glycemic abnormalities and admitted intensive care units versus from causes, evaluate adjusted attributable risk assess influence these dysglycemias mortality.We conducted a retrospective cohort consecutive suspected hospitalized...
In 2014-2015, the largest international survey of insulin injection technique in patients with diabetes taking was conducted 42 countries, totaling 13,289 participants. Brazil, from five public health centers were included. This study aims to evaluate Brazilian and compare results Latin America (LatAm) World data.The Injection Technique Questionnaire (ITQ) consisted an initial patient section (questions applied by experienced nurse), followed observation examination sites care...
We aimed to identify HLA-DRB1, -DQA1, and -DQB1 alleles/haplotypes associated with European, African, or Native American genomic ancestry (GA) in admixed Brazilian patients type 1 diabetes (T1D). This exploratory nationwide study enrolled 1599 participants. GA percentage was inferred using a panel of 46 informative marker-insertion/deletion. Receiver operating characteristic curve analysis (ROC) applied HLA class II alleles related GA, showed significant (p < 0.05) accuracy for...
Objectives To evaluate a postpartum telephone-based lifestyle intervention to prevent diabetes in high-risk women with recent gestational mellitus (GDM). Design Multicentre parallel randomised clinical trial. Setting Specialised antenatal clinics the Brazilian National System. Methods Lifestyle Intervention for Diabetes Prevention After Pregnancy compared (1:1) telephone support changes conventional care GDM at substantial risk diabetes. Randomisation started on 28 March 2015 and ended 13...
RACIONAL: Estudos recentes têm sugerido possível associação entre infecção pelo vírus da hepatite C (VHC) e diabetes melito tipo 2, relatando prevalência elevada de nessa população. OBJETIVO: Verificar a VHC em adultos portadores nosso meio. MÉTODOS: Foram avaliados consecutivamente 145 com 2 104 1, acompanhamento no ambulatório um hospital universitário, quanto à presença anticorpos contra (anti-VHC) por método ELISA quarta geração, utilizando como grupo controle 16 720 doadores sangue...