A5071207867- COVID-19 Clinical Research Studies
- Antifungal resistance and susceptibility
- Immune cells in cancer
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Gut microbiota and health
- Inflammasome and immune disorders
- Fungal Infections and Studies
- Long-Term Effects of COVID-19
- Immunodeficiency and Autoimmune Disorders
- Autoimmune and Inflammatory Disorders Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Response and Inflammation
- Blood disorders and treatments
- Malaria Research and Control
- Allergic Rhinitis and Sensitization
- Mycobacterium research and diagnosis
- Peptidase Inhibition and Analysis
- Immune Cell Function and Interaction
- Protein Tyrosine Phosphatases
- Extracellular vesicles in disease
- HIV Research and Treatment
- Phytochemistry Medicinal Plant Applications
- Asthma and respiratory diseases
- NF-κB Signaling Pathways
Universidade de São Paulo
2021-2024
Instituto Butantan
2024
Institute of Biomedical Science
2021
Severe COVID-19 patients present a clinical and laboratory overlap with other hyperinflammatory conditions such as hemophagocytic lymphohistiocytosis (HLH). However, the underlying mechanisms of these remain to be explored. Here, we investigated transcriptome 1596 individuals, including in comparison healthy controls, acute inflammatory states (HLH, multisystem syndrome children [MIS-C], Kawasaki disease [KD]), different respiratory infections (seasonal coronavirus, influenza, bacterial...
Several perturbations in the number of peripheral blood leukocytes, such as neutrophilia and lymphopenia associated with Coronavirus disease 2019 (COVID-19) severity, point to systemic molecular cell cycle alterations during severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. However, landscape COVID-19 remains primarily unexplored. Here, we performed an integrative systems immunology analysis publicly available proteome transcriptome data characterize global changes...
The fact that the COVID-19 fatality rate varies by sex and age is poorly understood. Notably, outcome of SARS-CoV-2 infections mostly depends on control cytokine storm increasingly recognized pathological role uncontrolled neutrophil activation. Here, we used an integrative approach with publicly available RNA-Seq data sets nasopharyngeal swabs peripheral blood leukocytes from patients SARS-CoV-2, according to age. Female young infected exhibited a larger number differentially expressed...
Introduction Dengue virus infection is a global health problem lacking specific therapy, requiring an improved understanding of DENV immunity and vaccine responses. Considering the recent emerging new dengue vaccines, here we performed integrative systems vaccinology characterization molecular signatures triggered by natural (NDI) attenuated models (DVTs). Methods results We analyzed 955 samples transcriptomic datasets patients with NDI trials (DVT1, DVT2, DVT3) using approach. Differential...
Fungal infections represent a major global health problem affecting over billion people that kills more than 1.5 million annually. In this study, we employed an integrative approach to reveal the landscape of human immune responses Candida spp. through meta-analysis microarray, bulk, and single-cell RNA sequencing (scRNA-seq) data for blood transcriptome. We identified across these different studies consistent interconnected network interplay signaling molecules involved in both Toll-like...
Background; Cell-released extracellular vesicles (EVs) acting as 'metabolically and proteolytically active machines,' show potential in metabolomic proteomic analysis of serum EVs. Despite diverse challenges, post-isolation omics characterization EVs offers crucial insights for effective analysis; (2) Methods: The research, involved children with Congenital Zika Syndrome, utilizing mass spectrometry proteomics GC-MS metabolite identification. Vesicles were isolated using...
Neutrophils are produced in the BM a process called granulopoiesis, which progenitor cells sequentially develop into mature neutrophils. During developmental process, is finely regulated by distinct transcription factors, neutrophils acquire ability to exit BM, properly distribute throughout body, and migrate infection sites. Previous studies have demonstrated that CD40 ligand (CD40L) influences hematopoiesis granulopoiesis. Here, we investigate effect of CD40L on neutrophil development...
Abstract Severe COVID-19 patients present a clinical and laboratory overlap with other hyperinflammatory conditions such as hemophagocytic lymphohistiocytosis (HLH). However, the underlying mechanisms of these remain to be explored. Here, we investigated transcriptome 1596 individuals, including in comparison healthy controls, acute inflammatory states (HLH, multisystem syndrome children [MIS-C], Kawasaky disease [KD]), different respiratory infections (seasonal coronavirus, influenza,...
Background: In this study, we investigated the role of extracellular vesicles (EVs) in pathogenesis Congenital Zika Syndrome (CZS). Previous studies have highlighted EVs intercellular communication and modulation biological processes during viral infections, motivating our in-depth analysis. Our objective was to identify specific molecular signatures patients with CZS, focusing on their potential as biomarkers cellular pathways affected by infection. Methods: We conducted advanced proteomic...
Abstract Here we employed a stepwise, integrative, and systems immunology approach to unravel the human immune responses C. albicans auris by analyzing publicly available transcriptome data. Modular gene co-expression analysis revealed an interplay between Toll-like Receptors (TLR) Interferon (IFN) networks. Enrichment analyses hierarchical clustering that this relationship is consistently triggered in peripheral white blood cells, mononuclear dendritic cell transcriptomes, involving IFN-γ,...
ABSTRACT The coronavirus disease 2019 (COVID-19) fatality rate varies in different patient groups. However, the underlying mechanisms that explain this variation are poorly understood. Here, we reanalyzed and integrated public RNAseq datasets of nasopharyngeal swabs peripheral blood leukocytes from patients with SARS-CoV-2, comparing transcription patterns according to sex, age, viral load. We found female young infected by SARS-CoV-2 exhibited a similar transcriptomic pattern larger number...
Abstract Fungal infections represent a major global health problem that affects over billion people and kills more than 1.5 million individuals annually. Here we employed an integrative approach to unravel the landscape of human immune responses Candida spp. ( C. albicans auris ) by performing meta-analysis microarray, bulk, single-cell RNA-sequencing (RNASeq) blood transcriptome data. We identified activates network interplay signaling molecules commonly involved in both toll-like receptor...
Abstract Dengue virus (DENV) infection is a global health problem with no specific therapy or vaccine currently available to combat it. Here we performed comprehensive analysis of publicly transcriptome data patients natural DENV (NDI) and trials (DVT1, DVT2, DVT3), identifying common transcriptional signatures according the time in NDI DVTs, disease severity NDI. We identified 237 differentially expressed genes (DEGs) between DVT1. Of those, 20 were commonly affected by dengue vaccination...
Clinical and hyperinflammatory overlap between COVID-19 hemophagocytic lymphohistiocytosis (HLH) has been reported. However, the underlying mechanisms are unclear. Here we show that HLH have an of signaling pathways gene signatures commonly dysregulated, which were defined by investigating transcriptomes 1253 subjects (controls, COVID-19, patients) using microarray, bulk RNA-sequencing (RNAseq), single-cell RNAseq (scRNAseq). share involved in cytokine chemokine as well neutrophil-mediated...
Abstract Fungal infections represent a major global health problem that affects over billion people and kills more than 1.5 million individuals annually. Here we employed an integrative approach to unravel the landscape of human immune responses Candida spp. by performing meta-analysis microarray, bulk, single-cell RNA-sequencing (RNASeq) blood transcriptome data. We identified across these different studies consistent interconnected network interplay signaling molecules involved in both...