A5048226106- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Alcohol Consumption and Health Effects
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Long-Term Effects of COVID-19
- Amino Acid Enzymes and Metabolism
- Metabolism and Genetic Disorders
- COVID-19 Clinical Research Studies
- Fatty Acid Research and Health
- Extracellular vesicles in disease
- Adipose Tissue and Metabolism
- SARS-CoV-2 and COVID-19 Research
- Endoplasmic Reticulum Stress and Disease
- Cancer, Hypoxia, and Metabolism
- Cholesterol and Lipid Metabolism
Universidad Complutense de Madrid
2020-2024
Metabolic-associated fatty liver disease (MAFLD) has risen as one of the leading etiologies for hepatocellular carcinoma (HCC). Oncogenes have been suggested to be responsible high risk MAFLD-related HCC. We analyzed impact proto-oncogene c-MYC in development human and murine MAFLD MAFLD-associated HCC.alb-myctg mice were studied at baseline conditions after administration Western diet (WD) comparison WT littermates. expression was biopsies patients with HCC by immunohistochemistry.Mild...
Individuals exhibiting an intermediate alcohol drinking pattern in conjunction with signs of metabolic risk present clinical features both alcohol-associated and metabolic-associated fatty liver diseases. However, such combination remains unexplored area great interest, given the increasing number patients affected. In study, we aimed to develop a preclinical DUAL (alcohol-associated disease plus disease) model mice. C57BL/6 mice received 10% vol/vol sweetened water Western diet for 10, 23,...
The outbreak of the novel coronavirus SARS-CoV-2 epidemic has rapidly spread and still poses a serious threat to healthcare systems worldwide. In present study, electronic medical records containing clinical indicators related liver injury in 799 COVID-19-confirmed patients admitted hospital Madrid (Spain) were extracted analyzed. Correlation between disease outcome was also evaluated. Serum levels Alanine aminotransferase (ALT), Aspartate (AST), Gamma-glutamyltransferase (GGT), Alkaline...
Lately, many countries have restricted or even banned transfat, and palm oil has become a preferred replacement for food manufacturers. Whether is potentially an unhealthy mainly due to its high content of saturated Palmitic Acid (PA) matter debate. The aim this study was test whether qualitative aspects diet such as levels PA the fat source are risk factors Metabolic Syndrome (MS) Associated Fatty Liver Disease (MAFLD).C57BL/6 male mice were fed 14 weeks with three types Western (WD): 1....
Expression of P21, encoded by the
Cyclin E1 is the regulatory subunit of cyclin-dependent kinase 2 (Cdk2) and one central players in cell cycle progression. We recently showed its crucial role for initiation liver fibrosis hepatocarcinogenesis. In present study, we investigated development alcohol-associated disease (ALD).Mice with constitutive (E1-/-), hepatocyte-specific (Cyclin E1Δhepa), or intestinal-epithelial-cell-specific E1ΔIEC) inactivation corresponding wild type littermate controls (WT) were administered either a...
Background and Aims Chronic alcohol intake is an important risk factor for Metabolic Associated Fatty Liver Disease (MAFLD) progression. However, the patients with dual clinical features of MAFLD ALD (alcohol-associated liver disease) represent a large, understudied area in hepatology huge unmet need preclinical studies. In present study we evaluated compared extent damage, steatosis, inflammation, fibrosis DUAL murine model main focus on gender related differences.