A5003464543- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Pancreatic and Hepatic Oncology Research
- Liver physiology and pathology
- Cancer-related Molecular Pathways
- Alcohol Consumption and Health Effects
- Diet, Metabolism, and Disease
Universitätsklinikum Aachen
2024
RWTH Aachen University
2023
Hepatocellular carcinoma (HCC) is one of the most severe malignancies with increasing incidence and limited treatment options. Typically, HCC develops during a multistep process involving chronic liver inflammation fibrosis. The latter characterized by accumulation extracellular matrix produced Hepatic Stellate Cells (HSCs). This involves cell cycle re-entry proliferation normally quiescent HSCs in an ordered sequence that highly regulated cyclins associated cyclin-dependent kinases (CDKs)...
Cyclin E1 mediates important steps within the cell cycle. We previously identified unexpected essential functions of for liver fibrogenesis, inflammation and hepatocarcinogenesis. However, effector cells in have not yet been fully identified. Here, we investigated role immune during acute inflammation.
Cyclin E1 is the regulatory subunit of cyclin-dependent kinase 2 (Cdk2) and one central players in cell cycle progression. We recently showed its crucial role for initiation liver fibrosis hepatocarcinogenesis. In present study, we investigated development alcohol-associated disease (ALD).Mice with constitutive (E1-/-), hepatocyte-specific (Cyclin E1Δhepa), or intestinal-epithelial-cell-specific E1ΔIEC) inactivation corresponding wild type littermate controls (WT) were administered either a...