A5025600930- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Diet, Metabolism, and Disease
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Metabolism, Diabetes, and Cancer
- Endoplasmic Reticulum Stress and Disease
- Pancreatic and Hepatic Oncology Research
- Cholesterol and Lipid Metabolism
- Dietary Effects on Health
- Clostridium difficile and Clostridium perfringens research
- Gastrointestinal motility and disorders
- Pancreatic function and diabetes
- Fatty Acid Research and Health
- Neuroblastoma Research and Treatments
- Gut microbiota and health
- Cancer, Hypoxia, and Metabolism
- Amino Acid Enzymes and Metabolism
Universidad Complutense de Madrid
2018-2024
Research Institute Hospital 12 de Octubre
2020-2024
Alcohol misuse, binge drinking pattern, and gender-specific effects in the middle-aged population has been clearly underestimated. In present study, we focused on understanding of alcohol exposure gut-liver axis role gut microbiota modulating responses to consumption.
The prognosis of patients with advanced high-grade (G3) digestive neuroendocrine neoplasms (NENs) is rather poor. addition immune checkpoint inhibition to platinum-based chemotherapy may improve survival. NICE-NEC (NCT03980925) a single-arm, phase II trial that recruited chemotherapy-naive, unresectable or metastatic G3 NENs gastroenteropancreatic (GEP) unknown origin. Patients received nivolumab 360 mg intravenously (iv) on day 1, carboplatin AUC 5 iv and etoposide 100 mg/m
Metabolic-associated fatty liver disease (MAFLD) has risen as one of the leading etiologies for hepatocellular carcinoma (HCC). Oncogenes have been suggested to be responsible high risk MAFLD-related HCC. We analyzed impact proto-oncogene c-MYC in development human and murine MAFLD MAFLD-associated HCC.alb-myctg mice were studied at baseline conditions after administration Western diet (WD) comparison WT littermates. expression was biopsies patients with HCC by immunohistochemistry.Mild...
Individuals exhibiting an intermediate alcohol drinking pattern in conjunction with signs of metabolic risk present clinical features both alcohol-associated and metabolic-associated fatty liver diseases. However, such combination remains unexplored area great interest, given the increasing number patients affected. In study, we aimed to develop a preclinical DUAL (alcohol-associated disease plus disease) model mice. C57BL/6 mice received 10% vol/vol sweetened water Western diet for 10, 23,...
Binge drinking, i.e., heavy episodic drinking in a short time, has recently become an alarming societal problem with negative health impact. However, the harmful effects of acute alcohol injury gut-liver axis remain elusive. Hence, we focused on physiological and pathological changes underlying mechanisms experimental binge context axis. Eight-week-old mice C57BL/6 background received single dose (p.o.) ethanol (EtOH) [6 g/kg b.w.] as preclinical model injury. Controls PBS. Mice were...
Lately, many countries have restricted or even banned transfat, and palm oil has become a preferred replacement for food manufacturers. Whether is potentially an unhealthy mainly due to its high content of saturated Palmitic Acid (PA) matter debate. The aim this study was test whether qualitative aspects diet such as levels PA the fat source are risk factors Metabolic Syndrome (MS) Associated Fatty Liver Disease (MAFLD).C57BL/6 male mice were fed 14 weeks with three types Western (WD): 1....
Expression of P21, encoded by the
Cyclin E1 is the regulatory subunit of cyclin-dependent kinase 2 (Cdk2) and one central players in cell cycle progression. We recently showed its crucial role for initiation liver fibrosis hepatocarcinogenesis. In present study, we investigated development alcohol-associated disease (ALD).Mice with constitutive (E1-/-), hepatocyte-specific (Cyclin E1Δhepa), or intestinal-epithelial-cell-specific E1ΔIEC) inactivation corresponding wild type littermate controls (WT) were administered either a...