A5062966830- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Thyroid Disorders and Treatments
- Ion channel regulation and function
- Liver Disease and Transplantation
- Drug-Induced Hepatotoxicity and Protection
- Alcohol Consumption and Health Effects
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Fatty Acid Research and Health
- Endoplasmic Reticulum Stress and Disease
- Growth Hormone and Insulin-like Growth Factors
- Dietary Effects on Health
- Cholesterol and Lipid Metabolism
- Lipid metabolism and biosynthesis
- Hepatitis C virus research
- Neuroscience of respiration and sleep
University of Lübeck
2021-2024
University Hospital Schleswig-Holstein
2023
Universidad Complutense de Madrid
2020-2021
Mutations in thyroid hormone receptor α1 (TRα1) cause Resistance to Thyroid Hormone α (RTHα), a disorder characterized by hypothyroidism TRα1-expressing tissues including the heart. Surprisingly, we report that treatment of RTHα patients with thyroxine overcome tissue resistance does not elevate their heart rate. Cardiac telemetry male, TRα1 mutant, mice indicates such persistent bradycardia is caused an intrinsic cardiac defect and due altered autonomic control. Transcriptomic analyses show...
Agonists for thyroid hormone receptor β (TRβ) show promise in preclinical studies and clinical trials to improve non-alcoholic fatty liver disease. A recent study on human livers, however, revealed reduced TRβ expression steatohepatitis (NASH), indicating a developing resistance, which could constitute major obstacle those agonists. Using rapid NASH paradigm combining choline-deficient high-fat diet thermoneutrality, we confirm that declines during disease progression mice similar humans....
Individuals exhibiting an intermediate alcohol drinking pattern in conjunction with signs of metabolic risk present clinical features both alcohol-associated and metabolic-associated fatty liver diseases. However, such combination remains unexplored area great interest, given the increasing number patients affected. In study, we aimed to develop a preclinical DUAL (alcohol-associated disease plus disease) model mice. C57BL/6 mice received 10% vol/vol sweetened water Western diet for 10, 23,...
Binge drinking, i.e., heavy episodic drinking in a short time, has recently become an alarming societal problem with negative health impact. However, the harmful effects of acute alcohol injury gut-liver axis remain elusive. Hence, we focused on physiological and pathological changes underlying mechanisms experimental binge context axis. Eight-week-old mice C57BL/6 background received single dose (p.o.) ethanol (EtOH) [6 g/kg b.w.] as preclinical model injury. Controls PBS. Mice were...
Background: The development of obesity-associated comorbidities such as type 2 diabetes (T2D) and hepatic steatosis has been linked to selected microRNAs in individual studies; however, an unbiased genome-wide approach map T2D induced changes the miRNAs landscape human liver samples, a subsequent robust identification validation target genes are still missing. Methods: Liver biopsies from age- gender-matched obese individuals with (n=20) or without were used for microRNA microarray analysis....
Background: The development of obesity-associated comorbidities such as type 2 diabetes (T2D) and hepatic steatosis has been linked to selected microRNAs in individual studies; however, an unbiased genome-wide approach map T2D induced changes the miRNAs landscape human liver samples, a subsequent robust identification validation target genes are still missing. Methods: Liver biopsies from age- gender-matched obese individuals with (n=20) or without were used for microRNA microarray analysis....
De novo lipogenesis (DNL) in visceral adipose tissue (VAT) is associated with systemic insulin sensitivity. DNL VAT regulated through ChREBP activity and glucose uptake Glut4 (encoded by Slc2a4). Slc2a4 expression, activity, are decreased obesity, the underlying cause however remains unidentified. We hypothesize that increased DNA methylation an enhancer region of decreases expression obesity resistance. found SLC2A4 morbidly obese subjects high HbA1c (>6.5%, n = 35) decreased, whereas...
The development of obesity-associated comorbidities such as type 2 diabetes (T2D) and hepatic steatosis has been linked to selected microRNAs in individual studies; however, an unbiased genome-wide approach map T2D induced changes the miRNAs landscape human liver samples, a subsequent robust identification validation target genes is still missing.Liver biopsies from age- gender-matched obese individuals with (n=20) or without were used for microRNA microarray analysis. candidate validated 85...
Abstract Background Thyroid hormones regulate cardiac functions mainly via direct actions in the heart and binding to thyroid hormone receptor (TR) isoforms α1 β. While role of most abundantly expressed isoform, TRα1, is widely studied well characterized, TRβ regulating still poorly understood, primarily due accompanying elevation circulating mice lacking (TRβ-KO). However, their hyperthyroidism ameliorated at thermoneutrality, which allows studying without this confounding factor. Methods...
Abstract Background The development of obesity-associated comorbidities such as type 2 diabetes (T2D) and hepatic steatosis has been linked to selected microRNAs in individual studies; however, an unbiased genome-wide approach map T2D induced changes the miRNAs landscape human liver samples, a subsequent robust identification validation target genes is still missing. Methods Liver biopsies from age- gender-matched obese individuals with (n=20) or without were used for microRNA microarray...