A5086022134- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Mechanisms and Therapy
- Target Tracking and Data Fusion in Sensor Networks
- Hernia repair and management
- Multilevel Inverters and Converters
- Pelvic and Acetabular Injuries
- Machine Fault Diagnosis Techniques
- Endoplasmic Reticulum Stress and Disease
- Biliary and Gastrointestinal Fistulas
- Video Surveillance and Tracking Methods
- Breast Cancer Treatment Studies
- Pancreatic and Hepatic Oncology Research
- Liver Disease and Transplantation
- Epigenetics and DNA Methylation
- Infrared Target Detection Methodologies
- Peptidase Inhibition and Analysis
- Radiomics and Machine Learning in Medical Imaging
- Sensorless Control of Electric Motors
- Organ Transplantation Techniques and Outcomes
- Adaptive Control of Nonlinear Systems
- Pelvic floor disorders treatments
Wuxi People's Hospital
2015-2025
Nanjing Drum Tower Hospital
2021-2025
Universidad Complutense de Madrid
2019-2025
Xi'an Technological University
2015-2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Nanjing Medical University
2024
Zhongda Hospital Southeast University
2021-2023
Xi'an University of Technology
2021-2022
Shanghai East Hospital
2019-2022
Hospital General Universitario Gregorio Marañón
2021
Abstract Cholesterol gallstone disease is a worldwide common disease. supersaturation in gallbladder bile the prerequisite for its pathogenesis, while mechanism not completely understood. In this study, we find enrichment of gut microbiota (especially Desulfovibrionales) patients with Fecal transplantation from to gallstone-resistant strain mice can induce formation. Carrying Desulfovibrionales associated enhanced cecal secondary acids production and increase acid hydrophobicity facilitating...
The novel diagnostic term Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) requires at least one cardiovascular risk factor for diagnosis. While the relationship between gallstones and Non-Alcoholic Fatty (NAFLD) has been debated, association MASLD remains unclear. This cross-sectional study aimed to explore this using National Health Nutrition Examination Survey (NHANES) data from 2017 2020. Participants were stratified into two groups based on diagnosis, propensity score...
Significance Obesity is associated with hepatic steatosis and activation of the cJun NH 2 -terminal kinase (JNK) stress-signaling pathway. Studies in mice demonstrate that JNK deficiency liver prevents development steatosis. This observation suggests inhibition signaling may represent a possible treatment for However, long-term consequences are poorly understood. Here we loss causes changes cholesterol bile acid metabolism promote cholestasis, duct proliferation, intrahepatic...
Abstract Acetaminophen (APAP) hepatotoxicity induces endoplasmic reticulum (ER) stress which triggers the unfolded protein response (UPR) in hepatocytes. However, mechanisms underlying ER remain poorly understood, thus reducing options for exploring new pharmacological therapies patients with hyperacute liver injury. Eight-to-twelve-week-old C57BL/6J Xbp1 -floxed ( f/f ) and hepatocyte - specific knockout mice ∆hepa were challenged either high dose APAP [500 mg/kg] sacrificed at early (1–2...
This paper investigates the characteristics of dynamic nonlinearity and correlation water quality parameter information, as well gradient disappearance explosion caused by training data traditional RNN network model, etc. The long short-term memory structure (LSTM) is introduced to optimize connection weight threshold hidden layer. A new prediction model LSTM-RNN based on improved proposed setting number storage units in layer network, structural layers adjusting time window size set....
Background Hepatic lipid metabolism regulates biliary composition and influences the formation of cholesterol gallstones. The genes Hmgcr Cyp7a1 , which encode key liver enzymes, are regulated by circadian rhythm-related transcription factors. We aimed to investigate effect rhythm disruption on hepatic bile acid incidence stone formation. Methods Adult male C57BL/6J mice were fed either a lithogenic diet (LD) only during sleep phase (time-restricted feeding, TRF) or an LD ad libitum...
T lymphocytes, integral to the adaptive immune system, wield pivotal influence in bolstering anti-tumor responses, and are strictly regulated by ubiquitination modification. The objective of this investigation was devise a novel prognostic immunotherapeutic efficacy predictor for hepatocellular carcinoma patients utilizing cell-related genes (TCRUG).
Introduction: Laennec’s capsule serves as a critical anatomical landmark in liver resection. Despite its potential, lack of large-scale prospective studies limits the widespread use Laennec approach for minimally invasive hepatectomy. This multicenter cohort study aimed to compare outcomes traditional and approaches hepatectomy across multiple centers China. Methods: A total 445 patients from 11 were included, with 339 undergoing 106 receiving approach. Intraoperative parameters such...
Lung adenocarcinoma (LUAD) is a prevalent malignant tumor of the respiratory tract. The Kelch like ECH associated protein 1 (KEAP1)/nuclear factor erythroid 2‑related 2 (NRF2)/heme oxygenase (HO‑1) axis serves pivotal role in occurrence and progression LUAD. present study aimed to identify specific genes regulated by mutations KEAP1/NRF2/HO‑1 investigate their prognostic potential LUAD, as well association with microenvironment. Immunohistochemistry was performed assess expression levels...
The basement membrane (BM), an omnipresent extracellular matrix, plays a pivotal role as physiological element in the process of tumor metastasis. However, given heterogeneity colorectal cancer (CRC), prognosis is challengingly predictive. Therefore, we aim to construct prognostic model using BM-associated genes assess patient and clinical drug treatment effects. Non-negative Matrix Factorization (NMF) algorithm leverages characteristics or categories matrix rows columns achieve BMAG...
Liver transplantation (LT) is considered the optimal treatment approach for patients with cirrhosis progressing to hepatocellular carcinoma (HCC). LT not only allows complete removal of tumors from liver but also potentially eliminates cirrhosis. However, recurrence HCC after remains a significant issue, rates ranging 8% 20%. The median time 14 months, and survival 12.2 months. We present first case long-term remission following hepatic arterial infusion chemotherapy (HAIC) combined targeted...
<title>Abstract</title> <bold>Background and aims</bold> Although abdominal drainage tubes have been widely used to treat cholelithiasis, complications still affect patients' prognoses. There is no Standardized Nursing Process (SNP) for after Laparoscopic cholecystectomy (LC). This study aims observe the clinical efficacy explore feasibility of SNP intervention in cholelithiasis patients LC. <bold>Methods</bold> retrospective included with admitted Xishan People’s Hospital Wuxi City between...
Cholangiocarcinoma (CCA) is a devastating disease often detected at advanced stages when surgery cannot be performed. Conventional and targeted systemic therapies perform poorly, therefore effective drugs are urgently needed. Different epigenetic modifications occur in CCA contribute to malignancy. Targeting mechanisms may thus open therapeutic opportunities. However, such as DNA histone methylation coexist cooperate carcinogenesis. We tested the efficacy mechanism of action class dual G9a...
Metabolic-associated fatty liver disease (MAFLD) has risen as one of the leading etiologies for hepatocellular carcinoma (HCC). Oncogenes have been suggested to be responsible high risk MAFLD-related HCC. We analyzed impact proto-oncogene c-MYC in development human and murine MAFLD MAFLD-associated HCC.alb-myctg mice were studied at baseline conditions after administration Western diet (WD) comparison WT littermates. expression was biopsies patients with HCC by immunohistochemistry.Mild...
Individuals exhibiting an intermediate alcohol drinking pattern in conjunction with signs of metabolic risk present clinical features both alcohol-associated and metabolic-associated fatty liver diseases. However, such combination remains unexplored area great interest, given the increasing number patients affected. In study, we aimed to develop a preclinical DUAL (alcohol-associated disease plus disease) model mice. C57BL/6 mice received 10% vol/vol sweetened water Western diet for 10, 23,...
Background: Edmondson-Steiner (E-S) grade is a pathological indicator of the degree hepatocellular carcinoma (HCC) differentiation, and E-S III–IV poor prognostic factor for HCC patients. Predicting poorly differentiated has essential significance clinical decision-making. Although some studies have developed predictive models based on magnetic resonance imaging (MRI) radiomics, radiomic features that require specific software analysis are impractical work. This study aims to develop novel...
Targeted inhibition of the c‐Jun N‐terminal kinases (JNKs) has shown therapeutic potential in intrahepatic cholangiocarcinoma (CCA)‐related tumorigenesis. However, cell‐type‐specific role and mechanisms triggered by JNK liver parenchymal cells during CCA remain largely unknown. Here, we aimed to investigate relevance JNK1 JNK2 function hepatocytes two different models experimental carcinogenesis, dethylnitrosamine (DEN) model nuclear factor kappa B essential modulator (NEMO)...
Abstract Background Although laparoscopic pancreaticoduodenectomy (LPD) has been accepted worldwide for treating pancreatic ductal adenocarcinoma (PDA), it is a very technical and challenging procedure. Also, unclear whether LPD superior to open (OPD). This study summarized the experience efficacy of PDA in our medical center. Methods retrospective cohort included patients with admitted at Affiliated Hospital Jiangnan University from October 2019 January 2021. Patients received either or...
Caroli disease is a rare congenital disorder characterized by nonobstructive dilatation of intrahepatic ducts. In cases with symptomatic manifestations, treatment should correspond to the type hepatic resection for localized and transplantation diffuse forms. If possible, complete cysts can cure symptoms avoid risk malignancy. A 66-year-old woman presented Wuxi Xishan People's Hospital recurrent intermittent upper quadrant abdominal pain. Further examinations suggested diagnosis limited left...