A5044349781- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Alcohol Consumption and Health Effects
- Diet, Metabolism, and Disease
- Immune Cell Function and Interaction
- Metabolism, Diabetes, and Cancer
- COVID-19 Clinical Research Studies
- IL-33, ST2, and ILC Pathways
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- Metabolism and Genetic Disorders
- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Pharmacological Effects of Natural Compounds
- SARS-CoV-2 and COVID-19 Research
- Galectins and Cancer Biology
- Fatty Acid Research and Health
- Endoplasmic Reticulum Stress and Disease
- Long-Term Effects of COVID-19
- Pancreatitis Pathology and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Cholesterol and Lipid Metabolism
Universidad Complutense de Madrid
2018-2024
Hospital General Universitario Gregorio Marañón
2023
Metabolic-associated fatty liver disease (MAFLD) has risen as one of the leading etiologies for hepatocellular carcinoma (HCC). Oncogenes have been suggested to be responsible high risk MAFLD-related HCC. We analyzed impact proto-oncogene c-MYC in development human and murine MAFLD MAFLD-associated HCC.alb-myctg mice were studied at baseline conditions after administration Western diet (WD) comparison WT littermates. expression was biopsies patients with HCC by immunohistochemistry.Mild...
Background and Aims: Alcohol-associated liver disease (ALD) accounts for 70% of liver-related deaths in Europe, with no effective approved therapies. Although mitochondrial dysfunction is one the earliest manifestations alcohol-induced injury, restoring activity remains a problematic strategy due to oxidative stress. Here, we identify methylation-controlled J protein (MCJ) as mediator ALD progression hypothesize that targeting MCJ may help recovering fitness without collateral damage....
Individuals exhibiting an intermediate alcohol drinking pattern in conjunction with signs of metabolic risk present clinical features both alcohol-associated and metabolic-associated fatty liver diseases. However, such combination remains unexplored area great interest, given the increasing number patients affected. In study, we aimed to develop a preclinical DUAL (alcohol-associated disease plus disease) model mice. C57BL/6 mice received 10% vol/vol sweetened water Western diet for 10, 23,...
The outbreak of the novel coronavirus SARS-CoV-2 epidemic has rapidly spread and still poses a serious threat to healthcare systems worldwide. In present study, electronic medical records containing clinical indicators related liver injury in 799 COVID-19-confirmed patients admitted hospital Madrid (Spain) were extracted analyzed. Correlation between disease outcome was also evaluated. Serum levels Alanine aminotransferase (ALT), Aspartate (AST), Gamma-glutamyltransferase (GGT), Alkaline...
Lately, many countries have restricted or even banned transfat, and palm oil has become a preferred replacement for food manufacturers. Whether is potentially an unhealthy mainly due to its high content of saturated Palmitic Acid (PA) matter debate. The aim this study was test whether qualitative aspects diet such as levels PA the fat source are risk factors Metabolic Syndrome (MS) Associated Fatty Liver Disease (MAFLD).C57BL/6 male mice were fed 14 weeks with three types Western (WD): 1....
Non-alcoholic steatohepatitis (NASH) is a chronic liver disease associated with obesity, Diabetes mellitus type 2 (DM 2), and hyperlipidemia. It can also progress to irreversible cirrhosis end-stage hepatocellular carcinoma (HCC); however, the underlying mechanism still unknown, but endogenous (i.e. genetic) factors such as oncogenes have been suggested play role.
Cyclin E1 is the regulatory subunit of cyclin-dependent kinase 2 (Cdk2) and one central players in cell cycle progression. We recently showed its crucial role for initiation liver fibrosis hepatocarcinogenesis. In present study, we investigated development alcohol-associated disease (ALD).Mice with constitutive (E1-/-), hepatocyte-specific (Cyclin E1Δhepa), or intestinal-epithelial-cell-specific E1ΔIEC) inactivation corresponding wild type littermate controls (WT) were administered either a...
Based on recent clinical studies it has been suggested to refer patients with an intermediate alcohol drinking pattern and signs of metabolic risk, including obesity type 2 Diabetes Mellitus, i.e. features both alcoholic non-alcoholic steatohepatitis as BASH. Yet, BASH is not well described presents a large grey area in the field Hepatology huge unmet need pre-clinical new innovative experimental animal models.