A5076688614- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Inflammasome and immune disorders
- Pancreatitis Pathology and Treatment
- Gut microbiota and health
- Complement system in diseases
- Pediatric Hepatobiliary Diseases and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Enhanced Recovery After Surgery
- Immune Cell Function and Interaction
- Neonatal Health and Biochemistry
- Pharmacological Effects of Natural Compounds
- Immune cells in cancer
- Adenosine and Purinergic Signaling
- Organ Transplantation Techniques and Outcomes
- Gallbladder and Bile Duct Disorders
- Amoebic Infections and Treatments
- Clostridium difficile and Clostridium perfringens research
- Adipokines, Inflammation, and Metabolic Diseases
- Helicobacter pylori-related gastroenterology studies
- Inflammation biomarkers and pathways
- Phagocytosis and Immune Regulation
- Reproductive System and Pregnancy
- Drug-Induced Hepatotoxicity and Protection
RWTH Aachen University
2015-2025
Universitätsklinikum Aachen
2016-2025
There is a striking association between human cholestatic liver disease (CLD) and inflammatory bowel disease. However, the functional implications for intestinal microbiota inflammasome-mediated innate immune response in CLD remain elusive. Here we investigated role of gut-liver crosstalk murine Mdr2 knockout (Mdr2-/-) model resembling primary sclerosing cholangitis (PSC).Male Mdr2-/-, Mdr2-/- crossed with hepatocyte-specific deletion caspase-8 (Mdr2-/- /Casp8∆hepa) wild-type (WT) control...
Nonalcoholic fatty liver disease is seen as the hepatic manifestation of metabolic syndrome and represents most common in Western societies. The G protein-coupled chemokine receptor CX3CR1 plays a central role several syndrome-related manifestations involved maintaining intestinal homeostasis. Because diet-induced dysbiosis driver for nonalcoholic disease, we hypothesized that may influence development steatohepatitis. In two independent models steatohepatitis (high-fat diet...
Background and Aims Cholestatic liver injury leads to cell death subsequent inflammation fibrosis. As shown for primary biliary cholangitis (PBC), the mechanisms circuits between different pathways leading disease progression are incompletely defined. Common bile duct ligation (BDL) is a well‐established murine model mimic cholestatic injury. Here, we hypothesized that pyroptotic by Nucleotide‐Binding Domain, Leucine‐Rich‐Containing Family, Pyrin Domain‐Containing‐3 (Nlrp3) inflammasome...
Bile acids (BA) as important signaling molecules are considered crucial in development of cholestatic liver injury, but there is limited understanding on the involved cell types and pathways. The aim this study was to evaluate inflammatory fibrotic potential key BA role distinct subsets focusing NLRP3 inflammasome. C57BL/6 wild-type (WT) Nlrp3-/- mice were fed with a diet supplemented cholic (CA), deoxycholic (DCA) or lithocholic acid (LCA) for 7 days. Additionally, primary hepatocytes,...
Summary This study was performed to gain further insight in pro- and anticoagulant characteristics of leukocytes acute coronary syndrome (ACS). For this purpose, patients presenting on the emergency department (ED) with anginal chest pain were included study. In peripheral blood, procoagulant tissue factor (TF) expression measured different blood-borne phagocytes, i.e. neutrophilic granulocytes three monocyte subsets based CD14 CD16. Simultaneously, intracellular presence platelet-(CD41)...
V-set Ig-domain-containing 4 (VSIG4) is an immunomodulatory macrophage complement receptor modulating innate and adaptive immunity affecting the resolution of bacterial infections. Given its expression on peritoneal macrophages (PMs), we hypothesised a prognostic role VSIG4 concentrations in patients with spontaneous peritonitis (SBP).We isolated PMs from cirrhosis analysed release by flow cytometry, quantitative real-time PCR, ELISA, confocal microscopy. We measured soluble ascites 120 SBP...
Background MicroRNAs (miRNAs) play a pivotal role in modulating inflammatory responses and cell-cell interactions during bacterial infections. This study investigates the alterations miRNA composition patients with spontaneous peritonitis (SBP), identifies cellular sources, assesses functional consequences.
Cholestasis causes hepatic toxicity, which leads to liver injury by cell death. Apoptotic and pyroptotic death is a consequence of caspase-8 and/or caspase-1 activation mediated the NLRP3 inflammasome. triggers inflammation, fibrosis hepatocyte pyroptosis in mice. Thus we here studied role inflammasome during cholestatic injury.
Background and Aims V-set immunoglobulin-domain-containing 4 (VSIG4) is an immuno-modulatory macrophage complement receptor modulating innate adaptive immunity affecting the resolution of bacterial infections. Given its expression on peritoneal macrophages, we hypothesized a prognostic role VSIG4 concentrations in patients with spontaneous peritonitis.
Cholestasis causes hepatic toxicity which leads to liver injury by cell death. Apoptotic and pyroptotic death is a consequence of caspase-8 and/or caspase-1 activation mediated the NLRP3 inflammasome. triggers inflammation, fibrosis hepatocyte pyroptosis in mice. Thus we here studied role inflammasome during cholestatic injury. To investigate performed bile duct ligation (BDL) WT -/- We were interested study acute (first 48 hours) chronic (28 days) after BDL. Inflammation, evaluated with...
Accumulation of toxic bile salts in hepatocytes leads to hepatic toxicity and injury by cell death. Apoptotic pyroptotic death is a consequence caspase-8 or caspase-1 activation mediated the NLRP3 inflammasome. The inflammasome results liver inflammation, fibrosis hepatocyte pyroptosis mice. Thus we investigate what role during cholestatic injury.
Background Immune checkpoint receptors (ICRs) regulate immune responses by balancing the stimulatory and inhibitory signals delivered to cells antigen-presenting cells. Evidence suggests that membrane-bound soluble ICRs are dysregulated in liver disease, particularly alcoholic hepatitis. We hypothesized compartmentalized aberrantly regulated patients with acute failure (ACLF) spontaneous bacterial peritonitis (SBP).
Einleitung Membrangebundene und lösliche Immun-Checkpoints spielen eine entscheidende Rolle bei der Regulierung Aktivierung Hemmung von T-Zell-Populationen in Entzündungsprozessen.
Recent data highlight the role of intestinal dysbiosis and gut-liver interaction for progression alcoholic non-alcoholic fatty liver disease. However, functional implications microbiota inflammasome mediated innate immune response cholestatic disease is unclear. Here, we investigated crosstalk NLRP3 activation in murine Mdr2 knockout (Mdr2-/-) model resembling primary sclerosing cholangitis (PSC).