A5098085058- Alcohol Consumption and Health Effects
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
Universidad Complutense de Madrid
2023-2025
MetALD is a recently coined term that refers to systemic entity describe patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and simultaneous moderate alcohol consumption. The deleterious association of risk factors synergistically increases the development steatohepatitis, fibrosis, hepatocellular carcinoma (HCC). Despite its increasing incidence, pathophysiological mechanisms triggering damage in remain unclear. This review aims summarize prevalence,...
Cyclin E1 is the regulatory subunit of cyclin-dependent kinase 2 (Cdk2) and one central players in cell cycle progression. We recently showed its crucial role for initiation liver fibrosis hepatocarcinogenesis. In present study, we investigated development alcohol-associated disease (ALD).Mice with constitutive (E1-/-), hepatocyte-specific (Cyclin E1Δhepa), or intestinal-epithelial-cell-specific E1ΔIEC) inactivation corresponding wild type littermate controls (WT) were administered either a...