A5027984263- Pancreatic function and diabetes
- Diabetes and associated disorders
- Pluripotent Stem Cells Research
- Congenital heart defects research
- Metabolism, Diabetes, and Cancer
- Immune Cell Function and Interaction
- Digestive system and related health
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Neuroscience and Neural Engineering
- Ion channel regulation and function
Centro Andaluz de Biología Molecular y Medicina Regenerativa
2007-2024
Universidad Pablo de Olavide
2017-2024
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2017-2024
Junta de Andalucía
2021-2024
Universidad de Sevilla
2017-2024
Consejo Superior de Investigaciones Científicas
2017
Centro de Investigación Biomédica en Red
2007
Background and Aims: Alcohol-associated liver disease (ALD) accounts for 70% of liver-related deaths in Europe, with no effective approved therapies. Although mitochondrial dysfunction is one the earliest manifestations alcohol-induced injury, restoring activity remains a problematic strategy due to oxidative stress. Here, we identify methylation-controlled J protein (MCJ) as mediator ALD progression hypothesize that targeting MCJ may help recovering fitness without collateral damage....
LRH-1/NR5A2 is implicated in islet morphogenesis postnatally, and its activation using the agonist BL001 protects islets against apoptosis, reverting hyperglycemia mouse models of Type 1 Diabetes Mellitus. Islet transcriptome profiling revealed that expression PTGS2/COX2 increased by BL001. Herein, we sought to define role LRH-1 postnatal chart mode action conferring beta cell protection. ablation within developing cells impeded proliferation, correlating with growth retardation, weight...
GATA4 and GATA6 play essential, but redundant, roles in pancreas formation mice, mutations cause pancreatic agenesis humans. have also recently been linked to adult-onset diabetes, with subclinical or no exocrine insufficiency, suggesting an important role for human β-cell physiology. To investigate the of adult endocrine pancreas, we generated mice which Gata6 is specifically inactivated pancreas. These develop glucose intolerance. Islets deficient activity display decreased insulin content...
ABSTRACT The intricate etiology of type 1 diabetes mellitus (T1D), marked by a detrimental cross-talk between the immune system and insulin-producing β-cells, has impeded effective disease-modifying therapies. discovery that pharmacological activation nuclear receptor LRH-1/NR5A2 can reverse hyperglycemia in mouse models T1D attenuating autoimmune attack coupled to β-cell survival/regeneration, prompted us investigate whether tolerization could be achieved individuals with as well improving...
ABSTRACT We have previously described a role of LRH-1/NR5A2 in islet morphogenesis during postnatal development and reported that the treatment with BL001, an agonist LRH-1/NR5A2, protects islets against-stress induced apoptosis reverts hyperglycemia 3 mouse models Type 1 Diabetes Mellitus (T1DM). Islet transcriptome profiling revealed most differentially expressed genes after BL001 are involved immunomodulation, among them, increase PTGS2/COX2 expression. Herein, we dissected cellular...