A5100342564- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Nematode management and characterization studies
- Endoplasmic Reticulum Stress and Disease
- Cancer Mechanisms and Therapy
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Cell death mechanisms and regulation
- Hepatitis B Virus Studies
- Liver Diseases and Immunity
- Diet, Metabolism, and Disease
- Plant Growth Enhancement Techniques
- Animal Nutrition and Health
- Industrial Automation and Control Systems
- Agronomic Practices and Intercropping Systems
- Engineering and Technology Innovations
- Magnetic and Electromagnetic Effects
- Advanced biosensing and bioanalysis techniques
- Melanoma and MAPK Pathways
- Pancreatic function and diabetes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis C virus research
- Cytokine Signaling Pathways and Interactions
- Apelin-related biomedical research
RWTH Aachen University
2019-2025
Universitätsklinikum Aachen
2023
National Research Centre
2004-2021
Karary University
2021
Hepatic clearance of lipid nanoparticles (LNP) with encapsulated nucleic acids restricts their therapeutic applicability. Therefore, tools for regulating hepatic are high interest acid delivery. To this end, work employs wild-type (WT) and low-density lipoprotein receptor (Ldlr)
Abstract Lipid-based RNA nanocarriers have been recently accepted as a novel therapeutic option in humans, thus increasing the options for patients. Tailored nanomedicines will enable to treat chronic liver disease (CLD) and end-stage cancer, disorders with high mortality few treatment options. Here, we investigated curative potential of gene therapy key molecule CLD, c-Jun N-terminal kinase-2 ( Jnk2 ). Delivery hepatocytes was achieved using lipid-based clinically employable siRNA...
Background and Aims: Metabolic dysfunction-associated steatohepatitis (MASH) is associated with c-Jun N-terminal kinases (JNK) activation across various cell types, but its hepatocyte-specific function in steatotic liver disease remains unclear. Our study investigates the role of JNK1/JNK2 during MASH progression dissect function. Approach Results: We showed that UK biobank patients a predicted-loss-of-function (pLOF) variant JNK1 presented an increased prevalence MASLD damage. Analysis...
Targeted inhibition of the c‐Jun N‐terminal kinases (JNKs) has shown therapeutic potential in intrahepatic cholangiocarcinoma (CCA)‐related tumorigenesis. However, cell‐type‐specific role and mechanisms triggered by JNK liver parenchymal cells during CCA remain largely unknown. Here, we aimed to investigate relevance JNK1 JNK2 function hepatocytes two different models experimental carcinogenesis, dethylnitrosamine (DEN) model nuclear factor kappa B essential modulator (NEMO)...
Distribution and identification of phytonematodes associated with wheat grown in twelve provinces Northern Middle Egypt were investigated during two growing seasons (2016-2017 2017-2018). A total 929 soil root samples collected from 119 localities (villages/farms) belonging to 37 districts. Samples contained fourteen nematode genera species viz., Aphelenchoides, Criconemella, Ditylenchus, Helicotylenchus, Heterodera, Hirschmanniella oryzae, Hoplolaimus, Longidorus,Meloidogyne, Pratylenchus,...
Abstract Background & Aims Nonalcoholic fatty liver disease (NAFLD) is a major health burden associated with the metabolic syndrome leading to fibrosis, cirrhosis and ultimately cancer. In humans, PNPLA3 I148M polymorphism of phospholipase patatin‐like phospholipid domain containing protein 3 (PNPLA3) has well‐documented impact on disease. this study, we used mouse model mimicking human in long‐term high fat diet (HFD) experiment better define its role for NAFLD progression. Methods Male...
Cholestatic liver injury is associated with c-Jun N-terminal kinases (JNK) activation in distinct cell types. Its hepatocyte-specific function during cholestasis, however, has not yet been established. Therefore, our present study, we investigated the role of JNK1/2 cholestasis and dissected its function.A cohort patients primary biliary cholangitis (n = 29) sclerosing 37) was examined. Wild-type, knockout mice for Jnk2 (Jnk2Δhepa) or Jnk1 (Jnk1Δhepa/2Δhepa) were generated. Mice subjected to...
Expression of P21, encoded by the
A survey was conducted in 2014/2015 to study distribution of plant parasitic nematodes associated with the different vegetables, field crops, fruit trees, weeds and some ornamental plants grown Borg El-Arab Amryia counties (sugar beet district), North West Egypt .Data indicated that twelve nematode genera species were found at various percentages frequencies occurrence population densities according host type locality.The most predominant root-knot, Meloidogyne; stunt, Tylenchorhynchus;...
Objective: Acrylonitrile (a chemical pollutant) has been reported to induce harmful effects in humans. Therefore, this study was designed evaluate the protective of hesperidin, a natural bioflavonoid, against toxicity induced by acrylonitrile (AN) rats. Material&Methods: This includes determination serum total scavenger capacity “TSC”, liver enzymes (aspartate transaminase “ASAT”, alanine “ALAT” and alkaline phosphatase “ALP”), proteins, albumin, glucose, creatinine, urea lipid profile....
Fibropolycystic liver disease is characterized by hyperproliferation of the biliary epithelium and formation multiple dilated cysts, a process associated with unfolded protein response (UPR). In present study, we aimed to understand mechanisms cyst UPR activation in hepatocytic c-Jun N-terminal kinase 1/2 (Jnk1/2) knockout mice. Floxed JNK1/2 (Jnkf/f) Jnk∆hepa animals were sacrificed at different time points during progression disease. Histological examination specimens evidenced presence...
Abstract Progressive hepatic damage and fibrosis are major features of chronic liver diseases different etiology, yet the underlying molecular mechanisms remain to be fully defined. N-RAS, a member RAS family small guanine nucleotide-binding proteins also encompassing highly homologous H-RAS K-RAS isoforms, was previously reported modulate cell death renal fibrosis; however, its role in fibrogenesis remains unknown. Here, we approached this question by using N-RAS deficient (N-RAS −/− ) mice...
Relative susceptibility and tolerance of thirteen Egyptian wheat cultivars to the cereal cyst nematode Heterodera avenae were determined under greenhouse conditions.Resistance/ was assessed as relative (RS) standard susceptible control cultivar Sakha-93.The results showed that H. infected well reproduced on all tested cultivars, so them designated cultivars.Cultivars Misr-1, Misr-2, Misr-3 Shandaweel highly avenae, their more than 92%.Data also indicated Sakha-8, Sakha-93, Sakha-95, Giza-168...
Due to the ever increasing pressure on cultivated land importance of intercropping in farming practices has been recognized. This study was performed evaluate effect ryegrass (Lolium multiflorum lam) with fenugreek (Trigonella foenum-graecum L.). For this purpose, a field experiment arranged based randomized complete block design three replications at experimental farm faculty agriculture Cairo University Giza, Egypt during two seasons 2015 and 2016. The treatments were planting patterns...
Succulent twigs of Atriplex halimus naturally grown in Nubaria desert area were cut and sun dried (AH), or ensiled (AS).The AH was offered either alone with daily supplementation polyethelene glycol (20 g PEG/kg DMI) as a tannin complex agent to sheep goats.Berseem (Trifolium alexandrinum) hay (BH) used control.Animals crushed barley grains cover 50% maintenance requirements, while tested forages ad lib.The nutrients proximate analysis BH comparable that A. halimus.The average DM intake by...
Jnk1 and Jnk2 are the two major Jnk genes ubiquitously expressed in all mammalian cells, including hepatocytes. Inhibition of nuclear factor kappa B (NF-κB) activity via deletion NF-κB essential modulator (IKKγ/Nemo) triggers cell apoptosis, which subsequently promotes compensatory hepatocyte proliferation triggering c-Jun N-terminal kinases (JNK)-mediated hepatocarcinogenesis (HCC) prolonged activation. Thus, JNK/NF-κB interplay is a determinant for fate carcinogenesis. In this study, we...
Cholestatic liver injury (CLI) is one of the major causative factors for fibrosis. CLI triggers c-Jun N-terminal kinases (JNK) activation. Interestingly, we have previously shown that JNK1 responsible hepatic stellate cells (HSCs) activation in However as different cell types are involved determining relevance and/or 2 during fibrogenesis, aimed here to specifically define type specific role JNKs
The c-Jun NH2-terminal kinase (JNK) activation is required for cholestatic liver injury-induced fibrogenesis. Global JNK1 or JNK2 functions have been thoroughly addressed. Moreover, we showed that function in hepatic stellate cells (HSCs), but not hepatocytes mediates transactivation of HSCs during murine fibrosis. Here, tested the hypothesis and together work to confer protection
Background&Aim Fibropolycistic liver disease is characterized by hyperproliferation of the biliary epithelium and formation multiple dilated cysts, a process recently associated with unfolded protein response (UPR). In present study, we aimed to understand mechanisms cyst UPR activation hepatocyte-specific c-Jun N-terminal kinase 1/2 (Jnk1/2) knockout mice.
Background Chronic cholestasis triggers severe liver injury, inflammation and subsequently fibrosis associated with c-Jun N-terminal kinases (JNK) activation. However, the JNK specific role during in parenchymal non-parenchymal cells (NPCs) has not been defined yet. Previously, we demonstrated that Jnk1 hepatocytes no impact on chronic hepatic injury experimental fibrosis. Here, investigated relevance of Jnk2 but also specifically NPCs for cholestatic
Background Cholestatic liver injury is a major cause of fibrosis in patients with chronic disease and associated c-Jun N-terminal kinases (JNK) activation. Earlier, Jnk1 Jnk2 showed opposite functions cholestasis models. While Jnk1−/− mice were protected, Jnk2−/− more fibrosis. However, the cell-specific function JNKs during has not been defined. Here, we investigated cell-type-specific and/or for cholestasis.
This paper discussed the design and implementation of a Computer Numerical Control (CNC) machine for writing or sketch by employ parts computer scraps (DVD-ROM). The Arduino Uno used as controller this project with using Inkscape program, which converts images text into g- code format then sends to processing3 program is an interface connection between arduino language CNC machine. g-code includes set x y z coordinates that are sent motors, Z transmitted servo motor directs movement pen, Y...