A5067876973- Endoplasmic Reticulum Stress and Disease
- Cell death mechanisms and regulation
- Pneumocystis jirovecii pneumonia detection and treatment
- Liver physiology and pathology
- Parasitic infections in humans and animals
- Parasites and Host Interactions
Research Institute Hospital 12 de Octubre
2022-2023
Universidad Complutense de Madrid
2023
Max Planck Institute for Heart and Lung Research
2022
German Center for Lung Research
2022
Cardio-Pulmonary Institute
2022
Justus-Liebig-Universität Gießen
2022
HIV and Schistosoma infections have been individually associated with pulmonary vascular disease. Co-infection these pathogens is very common in tropical areas, an estimate of six million people co-infected worldwide. However, the effects co-exposure on vasculature its impact development disease are largely unknown. Here, we approached questions by using a non-infectious animal model based lung embolization mansoni eggs HIV-1 transgenic (HIV) mice. Schistosome-exposed mice but not wild-type...
Abstract Progressive hepatic damage and fibrosis are major features of chronic liver diseases different etiology, yet the underlying molecular mechanisms remain to be fully defined. N-RAS, a member RAS family small guanine nucleotide-binding proteins also encompassing highly homologous H-RAS K-RAS isoforms, was previously reported modulate cell death renal fibrosis; however, its role in fibrogenesis remains unknown. Here, we approached this question by using N-RAS deficient (N-RAS −/− ) mice...