A5047850187- COVID-19 Clinical Research Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammasome and immune disorders
- Phytochemistry Medicinal Plant Applications
- Immunotherapy and Immune Responses
- Neonatal and Maternal Infections
- S100 Proteins and Annexins
- Dermatological and COVID-19 studies
- Inflammation biomarkers and pathways
- Cervical Cancer and HPV Research
- Immune cells in cancer
- Venomous Animal Envenomation and Studies
- Long-Term Effects of COVID-19
- Poxvirus research and outbreaks
Universidade de São Paulo
2022-2023
Universidade de Ribeirão Preto
2022
Sanofi (United States)
2017
Abstract Background The release of neutrophil extracellular traps (NETs) is associated with inflammation, coagulopathy, and organ damage found in severe cases COVID-19. However, the molecular mechanisms underlying NETs COVID-19 remain unclear. Objectives We aim to investigate role Gasdermin-D (GSDMD) pathway on development during Methods performed a single-cell transcriptome analysis public data bronchoalveolar lavage. Then, we enrolled 63 hospitalized patients moderate analyze blood lung...
To achieve durable and broad protection against human papillomaviruses by vaccination with multimers of minor capsid antigen L2 using self-adjuvanting fusions the toll-like receptor-5 (TLR5) ligand bacterial flagellin (Fla) instead co-formulation alum. Fla protective epitopes comprising residues 11-200, 11-88 and/or 17-38 a single or multiple HPV types were produced in E. coli their capacity to activate TLR5 signaling was assessed. Immunogenicity evaluated serially following administration 3...
Abstract Background Inflammation in the lungs and other vital organs COVID-19 is characterized by presence of neutrophils a high concentration neutrophil extracellular traps (NETs), which seems to mediate host tissue damage. However, it not known whether NETs could have virucidal activity against SARS-CoV-2. Methods We investigated prevent SARS-CoV-2 replication epithelial cells what consequence degradation would be K18-humanized ACE2 transgenic mice infected with Results Here,...
Abstract The release of neutrophil extracellular traps (NETs) is associated with inflammation, coagulopathy, and organ damage found in severe cases COVID-19. However, the molecular mechanisms underlying NETs COVID-19 remain unclear. Using a single-cell transcriptome analysis we observed that expression GSDMD inflammasome-related genes were increased neutrophils from patients. Furthermore, high was structures lung tissue activation requires live SARS-CoV-2 occurs after infection via ACE2...
Neutrophil extracellular traps (NETs) are an important mechanism for defense against pathogens. Their overproduction can be harmful since excessive NET formation promotes inflammation and tissue damage in several diseases. Nucleases capable to degrade on basis of their DNA hydrolysis activity, including the CdcPDE, a nuclease isolated from Crotalus durissus collilineatus snake venom. Here, we report new finding about CdcPDE demonstrating its efficiency degrading cell-free NETs, being...