A5041533307- Pharmaceutical and Antibiotic Environmental Impacts
- Reproductive biology and impacts on aquatic species
- Environmental Toxicology and Ecotoxicology
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Aquaculture Nutrition and Growth
- Pesticide and Herbicide Environmental Studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Fish Ecology and Management Studies
- Pesticide Residue Analysis and Safety
- Peroxisome Proliferator-Activated Receptors
- Dialysis and Renal Disease Management
- Analytical chemistry methods development
- Fish Biology and Ecology Studies
- Cryospheric studies and observations
- Reproductive Biology and Fertility
- Marine Biology and Environmental Chemistry
- Climate change and permafrost
- Pharmacological Effects and Assays
- Aquaculture disease management and microbiota
- Liver Disease Diagnosis and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Aquatic Ecosystems and Biodiversity
- Adipose Tissue and Metabolism
- Physiological and biochemical adaptations
Universidade do Porto
2016-2025
Administração Regional de Saúde de Lisboa e Vale do Tejo
2025
Centro Interdisciplinar de Investigação Marinha e Ambiental
2009-2024
Hospitais da Universidade de Coimbra
2023
University of Aveiro
2019
Hospital Beatriz Ângelo
2019
University of Coimbra
1999-2018
Institute of Biomedical Science
2013-2018
Universidade Aberta
2018
Cooperativa de Ensino Superior Politécnico e Universitário
2003-2015
Calciphylaxis is an obliterative vasculopathy characterized by ischemic cutaneous necrosis secondary to the calcification of small- and medium-caliber blood vessels. This condition poses a significant therapeutic challenge often associated with poor outcomes. We report case 59-year-old man who had been on renal replacement therapy for 28 years presented painful necrotic ulcer his left leg, which progressively worsened over three weeks. A skin biopsy confirmed diagnosis calciphylaxis. The...
The concentrations and spreading of eight synthetic two natural progestins (PGs) were investigated in surface waters from ten sites at the Douro River Estuary. Samples filtrated subjected to solid-phase extraction (SPE) isolate concentrate target PGs. extracts cleaned by silica cartridges analyzed LC-MS/MS. finding biologically relevant amounts gonanes (22.3 ± 2.7 ng/L), progesterone derivatives (12.2 0.5 drospirenone (4.1 0.8 PGs (9.4 0.9 ng/L) support possibility these compounds acting as...
Understanding the impact of endocrine disruptor compounds (EDCs) across a wide range species is crucial, given their ubiquitous presence. Although invertebrate lack sex steroid hormone pathways, they exhibit sensitivity to EDCs, which could affect population dynamics. This study assessed reproductive endpoints and oxidative stress parameters in Eisenia fetida following exposure estradiol soy isoflavones, resembling concentrations found livestock manure. The experiment used artificial soil,...
The Ave River flows through the most urbanized and industrialized Porto district areas. Despite ovotestis was recently reported in male fish from estuary, no data exist on water levels of natural pharmaceutical estrogens (17β-estradiol, estrone, 17α-ethynylestradiol), xenoestrogenic industrial pollutants (4-octylphenol, 4-nonylphenol their mono diethoxylates, bisphenol A), phytoestrogens (formononetin, biochanin A, daidzein, genistein), sitosterol. Absence analyses applies to river, nearby...
This paper describes the development and validation of a simple analytical method using solid-phase extraction followed by high-performance liquid chromatography with diode array detection (HPLC-DAD) analysis. Target compounds included six pharmaceuticals (carbamazepine, diazepam, fluoxetine, propranolol, sulfamethoxazole, trimethoprim) active metabolite fenofibrate (fenofibric acid). Briefly, this consisted preconcentration water samples (2 L) on 500 mg Oasis HLB cartridges HPLC analysis...
A simple low-cost, analytical method based on microwave-assisted extraction of sediments, followed by solid phase micro-extraction and gas chromatography mass spectrometry, was developed validated for the quantification sixteen polycyclic aromatic hydrocarbons (PAHs) in marine estuarine sediment samples. The PAHs were those included United States Environmental Protection Agency (US EPA) priority list. Method detection limits between 0.07 0.76 µg/kg dry weight (dw), which makes current...