A5020812956- Analytical Chemistry and Chromatography
- Analytical chemistry methods development
- Pharmaceutical and Antibiotic Environmental Impacts
- Mass Spectrometry Techniques and Applications
- Advanced oxidation water treatment
- Microfluidic and Capillary Electrophoresis Applications
- Molecular spectroscopy and chirality
- Electrochemical Analysis and Applications
- Skin Protection and Aging
- Antibiotics Pharmacokinetics and Efficacy
- Radioactive element chemistry and processing
- Advancements in Transdermal Drug Delivery
- Enzyme Catalysis and Immobilization
- Metabolomics and Mass Spectrometry Studies
- Chemistry and Chemical Engineering
- Biosensors and Analytical Detection
- Monoclonal and Polyclonal Antibodies Research
- Advanced Photocatalysis Techniques
- Science and Education Research
- Spectroscopy and Chemometric Analyses
- Water Treatment and Disinfection
- Transgenic Plants and Applications
- Biotechnology and Related Fields
- Pesticide Residue Analysis and Safety
- Analytical Methods in Pharmaceuticals
Universidade de São Paulo
2015-2025
Universidade Federal de São Carlos
2010-2025
Universidade Estadual Paulista (Unesp)
2021-2022
IPO Porto
2022
China Agricultural University
2019
The performances of distinct BDD anodes (boron doping 100, 500 and 2500 ppm, with sp3/sp2 carbon ratios 215, 325, 284, respectively) in the electrochemical degradation ciprofloxacin – CIP (0.5 L 50 mg L−1 0.10 M Na2SO4, at 25 °C) were comparatively assessed using a recirculating flow system filter-press reactor. Performance was by monitoring total organic (TOC) concentrations, oxidation intermediates, antimicrobial activity against Escherichia coli as function electrolysis time. removal...
Dissolving microneedles (DMNs) is a promising technology for transdermal and intradermal drug delivery. However, effective decontamination protocols are necessary to ensure safety efficacy in clinical applications. The challenge use technique that preserves mechanical properties, does not introduce chemicals, can decontaminate DMNs without affecting the drug. With its potent antimicrobial properties minimal residual effects, ozone presents novel safe method decontaminating DMNs....
SMALL MOLECULES IN BIOLOGICAL MATRICES.Chromatographic methods are commonly used for analysis of small molecules in different biological matrices.An important step to be considered upon a bioanalytical method's development is the capacity yield reliable and reproducible results.This review discusses validation procedures adopted by governmental agencies, such as Food Drug Administration (USA), European Union (EU) Agência Nacional de Vigilância Sanitária (BR) quantification chromatographic...
This work reports the use of a two-dimensional liquid chromatography (2D-LC) system for quantification enantiomers omeprazole in distinct native aqueous matrices. An octyl restricted-access media bovine serum albumin column (RAM-BSA C(8)) was used first dimension, while polysaccharide-based chiral second dimension with either ultraviolet (UV-vis) or ion-trap tandem mass spectrometry (IT-MS/MS) detection. in-line configuration employed to assess exclusion capacity RAM-BSA columns humic...
Esta revisão versa sobre o uso de novas tecnologias no preparo amostras biológicas, com ênfase nos trabalhos reportados por pesquisadores brasileiros.A miniaturização, automação e injeção direta amostra intuito atender a demanda métodos mais eficientes menor geração resíduos, apresentam-se criticamente
Abstract This work reports the green organic chemistry synthesis of E ‐2‐cyano‐3(furan‐2‐yl) acrylamide under microwave radiation (55 W), as well use filamentous marine and terrestrial‐derived fungi, in first ene‐reduction 2‐cyano‐3‐(furan‐2‐yl) to (R)‐2‐cyano‐3‐(furan‐2‐yl)propanamide. The fungal strains screened included Penicillium citrinum CBMAI 1186, Trichoderma sp. 932 Aspergillus sydowii 935, terrestrial fungi FPZSP 146 152. A compound with an uncommon CN‐bearing stereogenic center at...
This paper reports the investigation of chiral interaction between 3,4-methylenedioxy-methamphetamine (MDMA) enantiomers and an immobilized polysaccharide-based phase. For that, suspended-state high-resolution magic angle spinning nuclear magnetic resonance spectroscopy (1H HR-MAS NMR) was used. 1H longitudinal relaxation time Saturation Transfer Difference (STD titration experiments were carried out yielding information at molecular level transient diastereoisomeric complexes MDMA...
Polysaccharide-based chiral stationary phases (CSP) demonstrate great versatility and higher selectivity for a variety of compounds in multimodal elution modes (normal, reverse polar organic). The main role CSP phenyl carbamate based derivatives as selectors is the formation diastereoisomeric complexes by means π-π interaction, dipole-dipole, hydrogen bonding and/or inclusion complex mechanisms. Nevertheless, mechanism behind their enantioselectivity requires clarification. High resolution...
Abstract This paper reports the enantioseparation of β‐hydroxy‐1,2,3‐triazole derivatives, which present a broad range biological properties, by supercritical fluid chromatography (SFC) and high‐performance liquid techniques (HPLC). Polysaccharide‐based chiral columns (cellulose amylose) were used to evaluate separation in SFC HPLC. Time analyses, consumption solvent, parameter optimization reduced using technique. The based on cellulose stationary phase 2‐propanol ethanol as modifiers...
Dissolving microneedles (DMNs) is a non-invasive intradermal or systemic drug delivery system. Considering topical photodynamic therapy (PDT) for non-melanoma skin cancer treatment, limited cream permeation one of the main issues. In this context, DMNs can improve prodrugs providing photosensitizer distribution within lesions. This study explored containing aminolevulinic acid (ALA) with Gantrez AN-139 considering manufacturing protocols, mechanical resistance, insertion capability, ALA...