A5024117292- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Nanoparticle-Based Drug Delivery
- Drug Solubulity and Delivery Systems
- Nanoplatforms for cancer theranostics
- Gold and Silver Nanoparticles Synthesis and Applications
- Pharmaceutical studies and practices
- Skin Protection and Aging
- Bee Products Chemical Analysis
- Muscle and Compartmental Disorders
- Dialysis and Renal Disease Management
- Dermatology and Skin Diseases
- Biological Activity of Diterpenoids and Biflavonoids
- Natural product bioactivities and synthesis
- Trigeminal Neuralgia and Treatments
- Edible Oils Quality and Analysis
- Antimicrobial Peptides and Activities
- Biosensors and Analytical Detection
- Nanoparticles: synthesis and applications
- Plant biochemistry and biosynthesis
- Advanced Fiber Optic Sensors
- Hidradenitis Suppurativa and Treatments
- Laser Applications in Dentistry and Medicine
- Parathyroid Disorders and Treatments
- Diabetes Management and Research
Hospital Braga
2025
Administração Regional de Saúde de Lisboa e Vale do Tejo
2025
Instituto Superior de Espinho
2024
Universidad de Alcalá
2015-2021
University of Lisbon
2019-2021
Universidade Lusófona
2012-2016
NAV (Portugal)
2014
University of Coimbra
2002-2005
Universidade de Caxias do Sul
2005
Cleveland Clinic
2005
Calciphylaxis is an obliterative vasculopathy characterized by ischemic cutaneous necrosis secondary to the calcification of small- and medium-caliber blood vessels. This condition poses a significant therapeutic challenge often associated with poor outcomes. We report case 59-year-old man who had been on renal replacement therapy for 28 years presented painful necrotic ulcer his left leg, which progressively worsened over three weeks. A skin biopsy confirmed diagnosis calciphylaxis. The...
Immunoglobulin A (IgA) vasculitis (IgAV), formerly known as Henoch-Schönlein purpura, is a small-vessel characterized by the deposition of IgA-containing immune complexes in vessel walls. While predominantly affecting pediatric population, adult-onset IgAV often presents with more severe clinical course and higher risk renal complications. Pulmonary-renal syndrome, diffuse alveolar hemorrhage glomerulonephritis, an exceedingly rare manifestation poses substantial diagnostic therapeutic...
Background Incremental hemodialysis (iHD) involves gradually increasing dialysis dose as residual kidney function (RKF) declines. RKF has been identified a strong predictor of patient survival. Given the importance maintaining in patients, our study aimed to analyze predictors accelerated loss those undergoing iHD. Methods We retrospectively analyzed 37 incident patients who started twice-weekly iHD between March 2017 and May 2022. Inclusion criteria were age ≥18 years, Kru ≥3 ml/min/1.73...
Tophaceous gout can present with aggressive tophi causing destruction of the soft tissues, joints, and bones (1,2). A 68-year-old male presented intense pain in upper lower limbs persisting for several weeks. He reported no limb weakness or history trauma. The patient's medical included severe tophaceous gout, chronic renal insufficiency, heart failure. patient had a poor social condition. On physical examination, he exhibited hygiene, cachexia, dehydration. Active drainage was observed....
Atopic dermatitis (AD) is a chronic inflammatory skin condition that affects mostly young infants. The purpose of this research was to achieve prolonged drug release and the reduction side effects with hydrocortisone-loaded nanoparticles (NPs), for AD treatment. Poly(ε-caprolactone) (PCL) NPs were prepared by modified solvent displacement method characterized in terms size, potential zeta, morphology, entrapment efficiency (EE), Fourier transform infrared (FT-IR) spectrometry vitro...
Photothermal response of plasmonic nanomaterials can be utilized for a number therapeutic applications such as the ablation solid tumors.Gold nanoparticles were prepared using different methods. After optimization, we applied an aqueous plant extract reducing and capping agent gold maximized near-infrared absorption (650-900 nm). Resultant showed good biocompatibility when tested in vitro human keratinocytes yeast Saccharomyces cerevisiae. Gold easily activated by controlled temperature with...
The application of functionalized nanocarriers on photothermal therapy for cancer ablation has wide interest. success this depends the therapeutic efficiency and biocompatibility system, but also stability biorecognition conjugated protein. This study aims at investigating hypothesis that EGF polymer-coated gold nanoparticles promote photostability EGFR internalization, making these particles suitable therapy. (100–200 nm) showed a plasmon absorption band located within near-infrared range...
The global impact of cancer emphasizes the importance developing innovative, effective and minimally invasive therapies. In context superficial cancers, development a multifunctional nanoparticle-based system its in vitro vivo safety efficacy characterization are, herein, proposed as proof-of-concept. This consists gold nanoparticles coated with hyaluronic oleic acids, functionalized epidermal growth factor for greater specificity towards cutaneous melanoma cells. nanoparticle is activated...
Currently, the innovative skin research is focused on development of novel topical formulations loaded with natural functional actives. The health benefits olive oil are unsurpassed and many others revealed as studies allow understanding its unlimited properties. Olive has a protective toning effect skin, but it not transported effectively into layers. Aiming cosmetic formulation for photoprotection hydration, we have prepared characterized macro-sized particles, made hydrogel polymer, oil....
6,7-dehydroroyleanone (DHR) is a cytotoxic abietane present in the essential oil of Plectranthus madagascariensis.Different extraction parameters were tested, and its optimization was accomplished with Clevenger apparatus-based hydrodistillation. After isolation, effect on microtubules, P-glycoprotein caspases assessed several cell lines compound coupled hybrid nanoparticles. The results show that DHR does not interfere microtubule formation, but evades resistance mechanisms P-glycoprotein....
Parvifloron D is a natural diterpene with broad and not selective cytotoxicity toward human tumor cells. In order to develop targeted antimelanoma drug delivery platform for D, hybrid nanoparticles were prepared biopolymers functionalized α-melanocyte stimulating hormone. Results/methodology: Nanoparticles produced according solvent displacement method the physicochemical properties assessed. It was shown that cytotoxic can induce, both as free encapsulated drug, cell death in melanoma cells...
The presence of aromatic residues and their close spatial proximity to disulphide bridges makes hen egg white lysozyme labile UV excitation. UVB induced photo-oxidation tryptophan tyrosine leads photochemical products, such as, kynurenine, N–formylkynurenine dityrosine the disruption in proteins. We here report that photochemistry is modulated by temperature, excitation power, illumination time, wavelength plasmonic quencher surfaces, as gold, natural fluorescence quenchers, hyaluronic acid...
A escolha de um método Microencapsulação adequado para promover o aumento da biodisponibilidade oral fármacos peptídicos depende das características físico-químicas do fármaco a encapsular, condições operacionais e dos polímeros utilizados. Nesta abordagem é feita uma avaliação diversos métodos sua aplicação na administração peptídeos proteínas. As técnicas que utilizam origem natural, não recorrendo drásticas preparação, são consideradas opções privilegiadas.
Case reports suggest that calcitonin gene-related peptide monoclonal antibodies (CGRP mAbs) may trigger inflammatory flares in patients with autoimmune diseases.
Existem, atualmente, centenas de peptídios e proteínas com ação terapêutica. Os obstáculos inerentes à sua administração oral têm impulsionado a investigação estratégias capazes os ultrapassar. Nesta revisão são abordados estes dois aspectos. A microencapsulação, pela versatilidade, sobressai entre as demais estratégias, afirmando-se como escolha potencial na fármacos peptídicos.
In a previous study, insulin was efficiently encapsulated in alginate microspheres using an emulsification/internal gelation process. However these showed high release at gastric pH, exposing the protein to harsh conditions of stomach. this our attempt improve profile by reinforcing matrix with dextran sulfate (DS). The size distribution not altered presence DS and encapsulation efficiency increased 100%. also able prevent pH 1.2, protecting from acidic environment. This effect explained...
Although light has long being used in medicine, scattering always hindered its use. This study intends to evolve into three different frontlines: development of methodologies concentrate inside biological tissues, an optical tissue phantom and multifunctional gold nanoparticles with therapeutic potential for targeting anticancer drug delivery. The impact the agent (milk) concentration measured wavefront spot radius is analyzed. Wavefront correction proves be efficient overcoming effect...
Atopic dermatitis is a chronic cutaneous pathology, which requires intensive skin care and pharmacological therapy; current available treatments still need urgent improvements, especially for long-term use specific groups (e.g.children).Nanotechnology has contributed with innovative drug delivery systems can offer effective targeted therapies.Study purposes were to prepare characterize hydrocortisone acetate-loaded polycaprolactone nanoparticles in terms of their physicochemical properties,...