A5089171606- Renal Diseases and Glomerulopathies
- Organ Donation and Transplantation
- Vasculitis and related conditions
- Diabetes Treatment and Management
- Dialysis and Renal Disease Management
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Urticaria and Related Conditions
- Cardiovascular Function and Risk Factors
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Systemic Lupus Erythematosus Research
- Parathyroid Disorders and Treatments
- Cardiac Imaging and Diagnostics
- Pulmonary Hypertension Research and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Chronic Kidney Disease and Diabetes
- Muscle and Compartmental Disorders
- Pharmacology and Obesity Treatment
- Diabetes Management and Research
Administração Regional de Saúde de Lisboa e Vale do Tejo
2025
Unidade Hospitalar de Bragança
2025
Hospital Braga
2021-2024
Calciphylaxis is an obliterative vasculopathy characterized by ischemic cutaneous necrosis secondary to the calcification of small- and medium-caliber blood vessels. This condition poses a significant therapeutic challenge often associated with poor outcomes. We report case 59-year-old man who had been on renal replacement therapy for 28 years presented painful necrotic ulcer his left leg, which progressively worsened over three weeks. A skin biopsy confirmed diagnosis calciphylaxis. The...
Immunoglobulin A (IgA) vasculitis (IgAV), formerly known as Henoch-Schönlein purpura, is a small-vessel characterized by the deposition of IgA-containing immune complexes in vessel walls. While predominantly affecting pediatric population, adult-onset IgAV often presents with more severe clinical course and higher risk renal complications. Pulmonary-renal syndrome, diffuse alveolar hemorrhage glomerulonephritis, an exceedingly rare manifestation poses substantial diagnostic therapeutic...
Introdução: As biópsias de tempo zero [time-zero biopsies (TzB)] fornecem informações sobre lesões provenientes do doador, mas seu valor preditivo para os resultados a longo prazo permanece incerto. O objetivo deste trabalho foi identificar fatores clínicos e histológicos das TzB doadores falecidos que influenciam taxa filtração glomerular (TFG) aos 3 5 anos pós-transplante renal. Métodos: Analisámos retrospectivamente realizadas janeiro 2015 agosto 2019. Foram excluídas 19 por óbito...
Background: Time-zero biopsies (TzB) provide insights into donor-derived lesions, but their predictive value for long-term outcomes remains uncertain. We aimed to identify clinical and histological factors from TzB of deceased donors influencing glomerular filtration rate (GFR) at 3- 5-year post-transplantation. Methods: retrospectively analyzed performed January 2015 August 2019. Nineteen were excluded due recipient death before 3 years. examined donor recipient-related characteristics...
Abstract Background IgA vasculitis is an inflammatory condition affecting blood vessels that poses a significant diagnostic and therapeutic challenge in clinical practice. Characterized by the deposition of immunoglobulin A (IgA) on vessel walls, this pathology can manifest various ways, presenting broad sometimes complex spectrum. Ninety percent cases occur pediatric age group. Severe lung involvement, such as pulmonary hemorrhage, rare patients with IgAV. We present case 33-year-old...
Abstract Background and Aims As we age, lose kidney function accumulate risk factors comorbidities that predispose to damage. However, disease can develop at any time. Life expectancy continues improve worldwide. For reason, more elderly patients are undergoing diagnostic biopsies (KB). There is a general reluctance in performing KB those patients. It important know if diagnosis have positive therapeutic impact. Method In this retrospective cohort study, analyzed the medical charts of all...
Abstract Background and Aims SGLT2 inhibitors (SGLT2i) have a beneficial effect in diabetic non-diabetic proteinuric chronic kidney disease (CKD), demonstrated large randomized controlled trials. However, there is limited information about real life experience with SGLT2i CKD like IgA nephropathy (IgAN). Method All patients biopsy-proven since 2015 were evaluated for use. We collected data on age, gender, the use of renin-angiotension-aldosterone system (RAASi), eGFR, glycosuria proteinuria...
Medeiros, Joana; Ribeiro, Bárbara; Carvalho, Renata; Bastos, José M.; Costa, Rui Ramalheiro, Antonio Author Information
Abstract Background and Aims Renal amyloidosis include amyloid A (AA) light chain (AL) as well amyloidogenic leukocyte chemotactic factor 2 (ALECT2) numerous hereditary forms. After identifying by its suggestive pale pink amorphous appearance in optic microscopy (OM) Congo red positivity, a correct diagnosis of the precursor protein is determinant to establish prognosis treatment. Immunohistochemistry (IHC) immunofluorescence (IF) studies use limited number antibodies detect specific...
Abstract Background and Aims Diabetic kidney disease (DKD) develops in almost half of diabetic patients is the leading cause chronic (CKD). SGLT2 inhibitors (SGLT2i) have consistently shown to confer protection with type 2 diabetes (T2D). The recent KDIGO guidelines suggest their use as a first line medication along metformin. After study CREDENCE was published, mid-2019, DKD at Nephrology outpatient department Hospital Braga were started on SGLT2i. We aimed assessing these patients’...