A5074074054- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Autoimmune Neurological Disorders and Treatments
- Prion Diseases and Protein Misfolding
- Peripheral Neuropathies and Disorders
- Transcranial Magnetic Stimulation Studies
- Neurological diseases and metabolism
- Hemoglobinopathies and Related Disorders
- Parkinson's Disease Mechanisms and Treatments
- Myasthenia Gravis and Thymoma
- Neurological and metabolic disorders
- Functional Brain Connectivity Studies
- Advanced Sensor and Energy Harvesting Materials
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Glycogen Storage Diseases and Myoclonus
- Amyotrophic Lateral Sclerosis Research
- CNS Lymphoma Diagnosis and Treatment
- Neural and Behavioral Psychology Studies
- Advanced Neuroimaging Techniques and Applications
- Nicotinic Acetylcholine Receptors Study
- Synthesis and Reactivity of Heterocycles
- Ion channel regulation and function
- Multiple Sclerosis Research Studies
- RNA regulation and disease
- Zoonotic diseases and public health
National Institute of Neurological Disorders and Stroke
2016-2023
National Institutes of Health
2016-2023
Louis Stokes Cleveland VA Medical Center
2018-2023
Case Western Reserve University
2017-2023
Cleveland Clinic
2013-2017
Alexandria University
2017
Torrance Memorial Medical Center
2017
Neurology, Inc
2017
Aultman Hospital
2016
ABSTRACT Introduction: Antibody against the acetylcholine receptor of autonomic ganglia (gAChR‐Ab) is implicated in pathogenesis autoimmune ganglionopathy (AAG) and several other disorders. Methods: This study was a retrospective evaluation 95 patients positive for gAChR‐Ab. Results: Twenty‐one (22%) had AAG, with greater median gAChR‐Ab level (0.21 nmol/L) higher percentage (57%) antibody levels >0.20 nmol/L when compared remaining 74 without manifestations (non‐AAG group, 0.10 15%,...
To determine the frequency of medication use in patients with dystonia enrolled an international biorepository study.In a cross-sectional analysis, we included 2,026 participants at 37 sites United States, Canada, Europe, and Australia through Project 1 Dystonia Coalition, study. The primary aim was to assess classes recommended for treating dystonia, secondary compare characteristics (disease type, age, sex, duration disease, comorbid conditions, severity).Querying database presence any...
Abstract Background Chorea‐acanthocytosis (ChAc) is associated with mutations of VPS13A , which encodes for chorein, a protein implicated in lipid transport at intracellular membrane contact sites. Objectives The goal this study was to establish the lipidomic profile patients ChAc. Methods We analyzed 593 species caudate nucleus (CN), putamen, and dorsolateral prefrontal cortex (DLPFC) from postmortem tissues four ChAc six without Results found increased levels...
Creutzfeldt-Jakob disease (CJD) and other prion diseases are rapidly progressive spongiform encephalopathies that invariably fatal. Clinical features magnetic resonance imaging, electroencephalogram, cerebrospinal fluid abnormalities may suggest disease, but a definitive diagnosis can only be made by means of neuropathologic examination. Fluorodeoxyglucose positron emission tomography (FDG-PET) is not routinely used to evaluate patients with suspected disease. This study includes 11 cases...
Antibodies against voltage-gated potassium channel (VGKC)-complex are implicated in the pathogenesis of acquired neuromyotonia, limbic encephalitis, faciobrachial dystonic seizure, and Morvan syndrome. Outside these entities, clinical value VGKC-complex antibodies remains unclear.We conducted a single-center review patients positive for over an 8-year period.Among 114 antibody, 11 (9.6%) carrying diagnosis encephalitis (n = 9) or neuromyotonia 2) constituted classic group, remaining 103...
ABSTRACT Background The etiology of cervical dystonia is unknown. Cholinergic abnormalities have been identified in animal models and human imaging studies. Some cholinergic neuronal loss the striatum increased acetylcholinesterase activity pedunculopontine nucleus. Objectives objective this study was to determine presence putamen nucleus brain donors. Methods Formalin‐fixed tissues were obtained from 8 7 age‐matched control brains (controls). Pedunculopontine available only 6 5 controls....
Abstract Sensory trick is a characteristic feature of cervical dystonia (CD), where light touch on the area adjacent to temporarily improves symptoms. Clinical benefit from sensory tricks can be observed before tactile contact made or even by imagination. The supplementary motor (SMA) may dynamically interact with sensorimotor network and other brain regions during in patients CD. In this study, we examined functional connectivity SMA at rest performance imagination CD compared healthy...
Abstract Background Vacuolar protein sorting 13 homolog A ( VPS13A ) disease, historically known as chorea‐acanthocytosis, is a rare neurodegenerative disorder caused by biallelic mutations in VPS13A, usually resulting reduced or absent levels of its product, VPS13A. localizes to contact sites between subcellular organelles, consistent with recently identified role lipid transfer membranes. Mutations are associated neuronal loss the striatum, most prominently caudate nucleus, and marked...
Patients with multiple sclerosis (MS) present to the emergency department (ED) for various reasons. Although true relapse is rarely underlying culprit, ED visits commonly result in new magnetic resonance imaging (MRI) and neurology admissions. We studied patients MS evaluated decision making regarding diagnostic/therapeutic interventions visit outcomes. identified potential areas improvement used data propose a triaging algorithm ED.We reviewed medical records from 176 2014.Ninety-seven 75...
Background: The mesial prefrontal cortex, cingulate and the ventral striatum are key nodes of human fronto-striatal circuit involved in decision-making executive function pathological disorders. Here we ask whether deep wide-field repetitive transcranial magnetic stimulation (rTMS) targeting cortex (MPFC) influences resting state functional connectivity. Methods: In Study 1, examined connectivity using multi-echo independent components analysis 154 healthy subjects to characterize default...
Although Essential Tremor is one of the most common movement disorders, current treatment options are relatively limited. Peripheral tremor suppression methods have shown potential, but we do not currently know which muscles responsible for patients' tremor, making it difficult to optimize methods. The purpose this study was quantify relationships between tremorogenic activity in throughout upper limb. Muscle recorded from 15 major superficial upper-limb 24 subjects with while they held...
OBJECTIVE: Describe the significance of voltage gated calcium channel antibody (VGCC-Ab) in evaluating neurological disorders. BACKGROUND: Association between VGCC-Ab, Lambert-Eaton Myasthenic Syndrome (LEMS), and small cell lung cancer (SCLC) is well known. However, abnormal VGCC-Ab levels were also observed autoimmune disorders, including cerebellar ataxia, dysautonomia, neuropathy, limbic encephalitis. DESIGN/METHODS: Paraneoplastic panels ordered 6032 patients from 2005 to 2013. 115...
Objective: Creutzfeldt–Jakob disease is a rapidly progressive spongiform encephalopathy. The E200K mutation found in majority of genetically transmitted cases. Methods: We describe the case and associated neuroimaging an E200K-129M gene-mutation-related fatal encephalopathy with resultant clinical insomnia thalamic changes. Results: A 46-year-old Caucasian male presented with, who was well until 2 months prior to admission, dementia followed by change personality auditory visual...
Abstract The mesial prefrontal cortex, cingulate cortex and the ventral striatum are key nodes of human fronto-striatal circuit involved in decision-making executive function pathological disorders. Here we ask whether deep wide-field repetitive transcranial magnetic stimulation (rTMS) targeting (MPFC) influences resting state functional connectivity. In Study 1, examined connectivity using multi-echo independent components analysis 154 healthy subjects to characterize default MPFC...
OBJECTIVE: Describe the clinical presentation and treatment, including electroconvulsive therapy (ECT), in a patient with limbic encephalitis-related catatonia. BACKGROUND: Limbic encephalitis is disorder characterized by acute-subacute onset of cognitive impairment, psychiatric disturbances, or seizures evidence medial temporal lobe system pathology. Onconeuronal cell surface antigen antibodies have been identified, but seronegative cases reported. In paraneoplastic cases, there may be...
Objective: Analyze the clinical presentation, neurologic diagnoses, and coexisting autoimmune neoplastic entities in a cohort of patients positive for VGKC-complex antibody. Background: Antibodies directed against voltage gated potassium channel complex (VGKC-complex) have been implicated pathogenesis acquired neuromyotonia, limbic encephalitis, Morvan’s syndrome. Outside such classic entities, value antibodies remains unclear. Methods: Single center retrospective review identified over an...