Leopoldo Luiz dos Santos‐Neto

ORCID: 0000-0002-8060-6111
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About
Contact & Profiles
Research Areas
  • Autoimmune and Inflammatory Disorders Research
  • Systemic Lupus Erythematosus Research
  • Rheumatoid Arthritis Research and Therapies
  • Multiple Sclerosis Research Studies
  • Malaria Research and Control
  • Mosquito-borne diseases and control
  • Trypanosoma species research and implications
  • Cardiovascular Syncope and Autonomic Disorders
  • Blood Pressure and Hypertension Studies
  • Complement system in diseases
  • Heart Rate Variability and Autonomic Control
  • Atherosclerosis and Cardiovascular Diseases
  • Pharmaceutical Practices and Patient Outcomes
  • Neurology and Historical Studies
  • Fibromyalgia and Chronic Fatigue Syndrome Research
  • Diversity and Career in Medicine
  • Brucella: diagnosis, epidemiology, treatment
  • SARS-CoV-2 and COVID-19 Research
  • Healthcare during COVID-19 Pandemic
  • T-cell and Retrovirus Studies
  • Global Health Workforce Issues
  • Lipid metabolism and disorders
  • Orthopedic Infections and Treatments
  • Orthopaedic implants and arthroplasty
  • Viral Infections and Vectors

Universidade de Brasília
2015-2024

Hospital Universitário de Brasília
2003-2019

Centro Universitário Euroamericano
2013

Hospital Central de las Fuerzas Armadas
2013

Universidade Católica de Brasília
2013

The treatments of choice in Alzheimer′s disease (AD) are cholinesterase inhibitors and NMDA‐receptor antagonists, although doubts remain about the therapeutic effectiveness these drugs. Herbal medicine products have been used treatment Behavioral Psychological Symptoms Dementia (BPSD) but with various responses. objective this article was to review evidences from controlled studies order determine whether herbs can be useful cognitive disorders elderly. Randomized assessing AD individuals...

10.1093/ecam/nel071 article EN cc-by Evidence-based Complementary and Alternative Medicine 2006-01-01

The article had the purpose of commenting on studies polypharmacy in elderly, focusing diagnosis and control. Polypharmacy is defined as use a number medications at same time additional drugs to correct drug adverse effects. fact that elderly take more for treatment several diseases makes them susceptible occurrence reactions. Prophylactic actions such balanced prescriptions are vital reduce incidence these reactions prevent longer hospital stay, increased costs aggravation health condition.

10.1590/s0034-89102006005000050 article EN cc-by Revista de Saúde Pública 2007-11-06

The purpose of the present study was to compare dynamic muscle strength, functional performance, fatigue, and quality life in premenopausal systemic lupus erythematosus (SLE) patients with low disease activity versus matched-healthy controls determine association strength SLE patients.We evaluated (18-45 years) (Systemic index [SLEDAI]: mean 1.5 ± 1.2). control (n = 25) patient groups were matched by age, physical characteristics, level activities daily (International Physical Activity...

10.1186/1471-2474-14-263 article EN cc-by BMC Musculoskeletal Disorders 2013-09-08

ABSTRACT Psychiatric disorders frequently occur in patients with multiple sclerosis (MS); however, limited reports are available on these comorbidities. We aimed to investigate the relationships among MS, anxiety, depression, and suicidal ideation. Methods: One hundred thirty two relapsing-remitting MS were evaluated using Expanded Disability Status Scale, Beck Depression Inventory-II (BDI-II), Scale for Suicide Ideation (BSI), Hospital Anxiety Scale. Results: A hierarchical regression...

10.1590/0004-282x20180036 article EN cc-by-nc Arquivos de Neuro-Psiquiatria 2018-05-01

A febre amarela é endêmica em alguns países. vacina, único modo eficaz de proteção, contra-indicada pacientes imunocomprometidos. Nosso objetivo relatar uma série casos reumatológicos, usuários imunossupressores, vacinados contra a doença. Foi feito um estudo retrospectivo, por meio questionário aplicado reumatológicos medicados com 60 dias antes da investigação. Foram avaliados 70 pacientes, idade média 46 anos, 90% mulheres, portadores artrite reumatóide (54), lupus eritematoso sistêmico...

10.1590/s0037-86822009000100006 article PT cc-by Revista da Sociedade Brasileira de Medicina Tropical 2009-02-01

Abstract: Physical activity has a protective effect on brain function in older people. Here, we briefly reviewed the studies and results related to effects of exercise cognitive impairment Alzheimer's disease. The main findings from current body literature indicate positive evidence for structured physical (cardiorespiratory resistance exercise) as promising non-pharmacological intervention preventing decline. More are needed determine mechanisms involved this preventative effect, including...

10.2147/ijgm.s35315 article EN cc-by-nc International Journal of General Medicine 2013-05-01

Examinar a associação entre qualidade de vida e distância percorrida no teste caminhada 6 minutos (6TC) em pacientes com lúpus eritematoso sistêmico (LES) na pré-menopausa, bem como comparar os resultados controle saudáveis. Foram pareadas por idade, características físicas nível atividade física (Questionário Internacional Atividade Física: s-IPAQ) 25 LES pré-menopausa (18–45 anos) baixa da doença (SLEDAI médio: 1,52 ± 1,61) controles. Ambos grupos não deviam estar envolvidos regular pelo...

10.1590/s0482-50042013000100008 article PT cc-by-nc-nd Revista Brasileira de Reumatologia 2013-01-01

Abstract Background Early rheumatoid arthritis (RA) offers an opportunity for better treatment outcomes. In real-life settings, grasping this might depend on access to specialized care. We evaluated the effects of early versus late assessment by rheumatologist diagnosis, initiation and long-term outcomes RA under conditions. Methods Adults meeting ACR/EULAR (2010) or ARA (1987) criteria were included. Structured interviews conducted. The was deemed “early” when first second physician...

10.1186/s42358-023-00301-7 article EN cc-by Advances in Rheumatology 2023-04-24

There is increasing evidence that neurofilament light chain (NF-L) can be considered as a biomarker for neuro-axonal damage. This polypeptide released into the cerebrospinal fluid (CSF) and blood, where it quantified. The concentration of NF-L elevated in patients with multiple sclerosis (MS) psychiatric disorders. We aimed to investigate levels CSF from treated MS relationship depression or anxiety. study involved three groups: control group (individuals without inflammation),...

10.1590/1414-431x202010428 article EN cc-by Brazilian Journal of Medical and Biological Research 2021-01-01

A critical role has been proposed for the switch from non-cytophilic IgG2 to cytophilic antibodies of IgG1 and IgG3 subclasses observed in humoral immune responses Plasmodium falciparum some Africans. These Africans have acquired clinically immunity naturally, after several years exposure holo-endemic malaria. In present study, possibility that life-long low levels malarial endemicity may be associated with changes IgG-subclass composition P. was investigated a native Amazonian community....

10.1080/00034989859807 article EN Annals of Tropical Medicine and Parasitology 1998-04-01

The aim of this study was to evaluate the effectiveness punctal occlusion using hypromellose 2% in patients with dry eye.In prospective, randomized single-blinded clinical trial, we evaluated 76 eyes 38 (36 women and 2 men) eye secondary rheumatic diseases. In each patient, lower lacrimal punctum 1 occluded 2%, whereas contralateral underwent a simulation procedure (control group). Patients' were assessed for burning, itching, redness, foreign body sensation, tearing based on visual scale...

10.1097/ico.0000000000000325 article EN Cornea 2014-12-16

INTRODUÇÃO: A artrite reumatoide (AR) é uma das principais indicações de artroplastia total do quadril (ATQ) ou joelho (ATJ). Estudos internacionais indicam a AR como fator risco para infecções prótese. OBJETIVOS: Comparação entre pacientes com e osteoartrite (OA) outras etiologias em relação à incidência prótese, incisionais sistêmicas pós-operatórias ATQ ATJ. MÉTODOS: Coorte retrospectiva, comparativa, acompanhados após realização ATJ no Hospital SARAH-Brasília, período 1996 2007....

10.1590/s0482-50042011000600007 article PT cc-by-nc-nd Revista Brasileira de Reumatologia 2011-12-01

To assess the association between quality of life and distance walked in 6-minute walk test (6MWT) Brazilian premenopausal patients with systemic lupus erythematosus (SLE) compare their results those healthy controls. Twenty-five (18–45 years) diagnosed low-activity SLE (mean SLEDAI: 1.52 ± 1.61) 25 controls were matched for age, physical characteristics, activity level (International Physical Activity Questionnaire/s-IPAQ). Both groups should not be involved regular at least six months...

10.1016/s2255-5021(13)70008-7 article EN cc-by-nc-nd Revista Brasileira de Reumatologia (English Edition) 2013-01-01

Introduction. International guidelines recommend interruption of anti-TNF medications in the perioperative period, but there are no randomized trials to support such recommendation. Objectives. To study literature evidence assessing risk surgical site infections orthopedic surgery patients with RA using drugs, compared untreated or those conventional DMARD. Methods. Systematic review cohort studies is concerning procedures RA. Results. Three were selected. Only one was considered...

10.1155/2012/369565 article EN cc-by International Journal of Rheumatology 2012-01-01
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