A5027613912- Surfactants and Colloidal Systems
- Lipid Membrane Structure and Behavior
- Supramolecular Self-Assembly in Materials
- RNA Interference and Gene Delivery
- Ionic liquids properties and applications
- Nanoparticle-Based Drug Delivery
- Enzyme Catalysis and Immobilization
- Polydiacetylene-based materials and applications
- Advanced Cellulose Research Studies
- Porphyrin and Phthalocyanine Chemistry
- HIV/AIDS oral health manifestations
- Supramolecular Chemistry and Complexes
- Polymer Surface Interaction Studies
- Biopolymer Synthesis and Applications
- Click Chemistry and Applications
- Advanced Polymer Synthesis and Characterization
- Carbon Nanotubes in Composites
- Nanopore and Nanochannel Transport Studies
- Advanced Nanomaterials in Catalysis
- Innovative Microfluidic and Catalytic Techniques Innovation
- Nanotechnology research and applications
- Diatoms and Algae Research
- Advanced biosensing and bioanalysis techniques
- Free Radicals and Antioxidants
- Hydrogels: synthesis, properties, applications
Universidade do Porto
2009-2024
Faculdade de Tecnologia e Ciências
2021
University of Minho
2012-2014
Cationic serine-based gemini surfactants have strong potential as compaction agents of nucleic acids for efficient non-viral gene delivery.
Stimuli-sensitive self-assembled nanostructures are relevant for efficient drug delivery and nanomaterial templating.
Ionic liquids derived from classical antimalarials are emerging as a new approach towards the cost-effective rescuing of those drugs. Herein, we disclose novel surface-active ionic chloroquine and natural fatty acids whose antimalarial activity in vitro was found to be superior that parent drug. The most potent liquid laurate salt chloroquine, which presented IC50 values 4 110 nM against chloroquine-sensitive chloroquine-resistant strain Plasmodium falciparum, respectively, corresponding an...
Synthetic amino acid-based surfactants possess versatile aggregation properties and are typically more biocompatible biodegradable than with conventional headgroups. This opens the possibility of a myriad specialty applications, namely in pharmaceutics, cosmetics, biomedicine, nanotemplating chemistry. In this work, we have investigated interfacial self-assembling aqueous medium novel double-chained lysine-based surfactants, particular focus on behavior dodecyl derivative, 12Lys12. Upon...
Interactions between polymers (P) and surfactants (S) in aqueous solution lead to interfacial aggregation phenomena that are not only of great interest physical chemistry but also important for many industrial applications, such as the development detergents fabric softeners. Here, we synthesized two ionic derivatives-sodium carboxymethylcellulose (NaCMC) quaternized cellulose (QC)-from recycled from textile wastes then explored interactions these with assorted surfactants-cationic (CTAB,...
In this work, we explore the ability of newly synthesized threonine-derived surfactants to form robust, versatile and cytocompatible catanionic vesicles when mixed with gemini surfactants, as potential effective nanocarriers for biomolecules.
Inspired by previous disclosure of room-temperature ionic liquids derived from primaquine and cinnamic acids, which displayed slightly enhanced blood-stage activity compared to the parent drug, we have now combined this emblematic antimalarial with natural fatty acids. This affords surface-active whose liver-stage antiplasmodial is either retained or enhanced, while revealing at least one order magnitude higher than that compound. These findings open new perspectives towards cost-effective...
Abstract Drug delivery vectors based on amphiphiles have important features such as versatile physicochemical properties and stimuli‐responsiveness. Amino acid‐based surfactants are especially promising due to their enhanced biocompatibility compared conventional surfactants. They can self‐organize into micelles, vesicles complex hierarchical structures, fibers, twisted coiled ribbons, tubules. In this work, we investigated the self‐assembly drug loading of a family novel anionic...
Cationic gemini surfactants have emerged as potential gene delivery agents they can co-assemble with DNA due to a strong electrostatic association. Commonly, complexation is enhanced by the inclusion of helper lipid (HL), which also plays key role in transfection efficiency. The formation lipoplexes, used non-viral vectors for transfection, through and hydrophobic interactions affected various physicochemical parameters, such cationic surfactant:HL molar ratio, (+/−) charge morphological...
Mixtures of cationic and anionic surfactants often originate bilayer structures, such as vesicles lamellar liquid crystals, that can be explored model membranes for fundamental studies or drug gene nanocarriers. Here, we investigated the aggregation properties two catanionic mixtures containing biomimetic derived from serine. The are designated 12Ser/8-8Ser 14Ser/10-10Ser, where mSer is a cationic, single-chained surfactant n-nSer an anionic, double-chained one (m n being C atoms in alkyl...