A5057181609- Surfactants and Colloidal Systems
- Lipid Membrane Structure and Behavior
- Supramolecular Self-Assembly in Materials
- Chemical Synthesis and Analysis
- Phenothiazines and Benzothiazines Synthesis and Activities
- HIV/AIDS drug development and treatment
- Analytical Chemistry and Chromatography
- Advanced Polymer Synthesis and Characterization
- Malaria Research and Control
- Polydiacetylene-based materials and applications
- Pickering emulsions and particle stabilization
- Microfluidic and Capillary Electrophoresis Applications
- Analytical chemistry methods development
- Hydrogels: synthesis, properties, applications
- Cancer therapeutics and mechanisms
- Click Chemistry and Applications
- Enzyme Catalysis and Immobilization
- Cancer and biochemical research
- Chemistry and Chemical Engineering
- Advanced Drug Delivery Systems
- Synthesis and biological activity
- Synthesis and bioactivity of alkaloids
- Advancements in Transdermal Drug Delivery
- Bioactive Compounds and Antitumor Agents
- Microbial Community Ecology and Physiology
Universidade do Porto
2008-2021
Rede de Química e Tecnologia
2016-2021
Universidade Federal do Pará
2019
Lund University
2008
University of Lisbon
2005
The Open University
2005
Uppsala University
1992
Imidazolidin-4-one derivatives of primaquine were synthesized as potential double prodrugs the parent drug. The title compounds inhibit development sporogonic cycle Plasmodium berghei, affecting appearance oocysts in midguts mosquitoes. imidazolidin-4-ones are very stable, both human plasma and pH 7.4 buffer, indicating that they active per se. Thus, derived from 8-aminoquinolines represent a new entry antimalarial structure−activity relationships.
The use of amino acids for the synthesis novel surfactants with vesicle-forming properties potentially enhances biocompatibility levels needed a viable alternative to conventional lipid vesicles. In this work, formation and characterization catanionic vesicles by newly synthesized lysine- serine-derived have been investigated means phase behavior mapping PFG-NMR diffusometry cryo-TEM methods. lysine-derived are double-chained anionic molecules bearing pseudogemini configuration, whereas...
Stimuli-sensitive self-assembled nanostructures are relevant for efficient drug delivery and nanomaterial templating.
Small, single-celled planktonic cyanobacteria are ubiquitous in the world's oceans yet tend not to be perceived as secondary metabolite-rich organisms. Here we report isolation and structure elucidation of hierridin C, a minor metabolite obtained from cultured picocyanobacterium Cyanobium sp. LEGE 06113. We describe simple, straightforward synthetic route scarcely produced hierridins that relies on key regioselective halogenation step. In addition, show these compounds originate type III PKS...
Synthetic amino acid-based surfactants possess versatile aggregation properties and are typically more biocompatible biodegradable than with conventional headgroups. This opens the possibility of a myriad specialty applications, namely in pharmaceutics, cosmetics, biomedicine, nanotemplating chemistry. In this work, we have investigated interfacial self-assembling aqueous medium novel double-chained lysine-based surfactants, particular focus on behavior dodecyl derivative, 12Lys12. Upon...
Amino acid-derived gemini surfactants arise as a potentially good alternative to the more conventional lipid and synthetic catanionic systems in view of their enhanced interfacial properties, increased chemical stability, low toxicity. The presence an amino acid polar headgroup allows toxicity reduction, with simultaneous increase biodegradability. For these compounds, establishment structure/function relationships from assessment basic aggregation properties is therefore utmost interest,...
Abstract Double-chained surfactants with potential biocompatibility have been prepared in high yields by lysine acylation four natural saturated fatty acids (C6 to C12) and cis-undec-5-enoic acid. The were found assemble into nanotubules aqueous medium and, when mixed a commercial cationic surfactant, spontaneously form liposomes.
Abstract Multi‐stage drugs have been prioritized in antimalarial drug discovery, as targeting more than one process the Plasmodium life cycle is likely to increase efficiency, while decreasing chances of emergence resistance by parasite. Herein, we disclose two novel acridine‐based families compounds that combine structural features primaquine and chloroquine. Compounds prepared studied thus far retained vitro activity displayed parent against erythrocytic stages chloroquine‐sensitive...
Abstract Drug delivery vectors based on amphiphiles have important features such as versatile physicochemical properties and stimuli‐responsiveness. Amino acid‐based surfactants are especially promising due to their enhanced biocompatibility compared conventional surfactants. They can self‐organize into micelles, vesicles complex hierarchical structures, fibers, twisted coiled ribbons, tubules. In this work, we investigated the self‐assembly drug loading of a family novel anionic...
For the first time under auspices of Sociedade Portuguesa de Química, competences two important fields Chemistry are brought together into a single event, 11st National Organic Meeting and 4th Medicinal Meeting, to highlight complementarities promote new synergies. Abstracts plenary lectures, oral communications, posters presented during meeting collected in this report.
Malaria is one of the deadliest infectious diseases in world. The eradication malaria has not yet been achieved, mainly due to emergence resistant parasites. Therefore, multi-target drugs have being prioritized antimalarial drug discovery, as targeting more than process Plasmodium life cycle likely increase efficiency, while decreasing chances resistance by parasite. In this sense, and keeping mind that cost-effective strategy repurpose existing for malaria, or rescue pharmacophores, we...
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”