A5068367516- Ionic liquids properties and applications
- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- Synthesis and Biological Evaluation
- Innovative Microfluidic and Catalytic Techniques Innovation
- Synthesis and biological activity
- Enterobacteriaceae and Cronobacter Research
- Antibiotics Pharmacokinetics and Efficacy
- Phenothiazines and Benzothiazines Synthesis and Activities
- Inorganic and Organometallic Chemistry
- Pharmacological Effects and Toxicity Studies
- Essential Oils and Antimicrobial Activity
- Antimicrobial Peptides and Activities
- Bacterial Identification and Susceptibility Testing
- Chemical Synthesis and Reactions
- Multicomponent Synthesis of Heterocycles
- Bone health and treatments
- Chemistry and Chemical Engineering
- Complement system in diseases
- Antimicrobial Resistance in Staphylococcus
- Aquaculture disease management and microbiota
- Bacterial biofilms and quorum sensing
- Polyamine Metabolism and Applications
- Nanomaterials for catalytic reactions
- Parkinson's Disease Mechanisms and Treatments
Polytechnic Institute of Porto
2016-2025
Universidade do Porto
2010-2024
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2015-2024
Universidade de Vigo
2018
Centro Hospitalar de Vila Nova de Gaia
2016
Rede de Química e Tecnologia
2011-2014
Hospitais da Universidade de Coimbra
2014
Universidade Nova de Lisboa
2012-2013
Instituto Politécnico Nacional
2006-2010
University of Minho
2002
This synopsis summarizes the key chemical and bacteriological characteristics of β-lactams, penicillins, cephalosporins, carbanpenems, monobactams others. Particular notice is given to first-generation fifth-generation cephalosporins. review also main resistance mechanism antibiotics, focusing particular attention those conferring broad-spectrum cephalosporins by means production emerging cephalosporinases (extended-spectrum β-lactamases AmpC β-lactamases), target alteration...
Antibiotics have been intensively used over the last decades in human and animal therapy livestock, resulting serious environmental public health problems, namely due to antibiotic residues concentration wastewaters development of antibiotic-resistant bacteria. This study aimed access contribution some anthropological activities, urban household, hospital a wastewater treatment plant, spread resistances treated released into Mondego River, Coimbra, Portugal. Six sampling sites were selected...
Novel ionic liquids containing ampicillin as an active pharmaceutical ingredient anion were prepared with good yields by using a new, efficient synthetic procedure based on the neutralization of moderately basic ammonia solution different organic cation hydroxides. The relevant physical and thermal properties these novel also evaluated.
Antibacterial activities of novel Active Pharmaceutical Ingredient Ionic Liquids (API–ILs) based on ampicillin anion [Amp] have been evaluated. They showed growth inhibition and bactericidal properties some sensitive bacteria especially Gram-negative resistant when compared to the [Na][Amp] initial bromide chloride salts. For these studies were analysed minimum inhibitory concentration (MIC) (MBIC) against Escherichia coli ATCC 25922 Klebsiella pneumoniae (clinically isolated), as well Gram...
The preparation and characterization of ionic liquids organic salts (OSILs) that contain anionic penicillin G [secoPen] amoxicillin [seco-Amx] hydrolysate derivatives their in vitro antibacterial activity against sensitive resistant Escherichiacoli Staphylococcusaureus strains is reported. Eleven hydrolyzed β-lactam-OSILs were obtained after precipitation moderate-to-high yields via the neutralization basic ammonia buffer antibiotics with different cation hydroxide salts. minimum inhibitory...
Betulinic acid is a naturally occurring compound that can be obtained through methanolic or ethanolic extraction from plant sources, as well chemical synthesis microbial biotransformation. has been investigated for its potential therapeutic properties, and exhibits anti-inflammatory, antiviral, antimalarial, antioxidant activities. Notably, ability to cross the blood-brain barrier addresses significant challenge in treating neurological pathologies. This review aims compile information about...
Significant antiproliferative effects against various tumor cell lines were observed with novel ampicillin salts as ionic liquids. The combination of anionic appropriate ammonium, imidazolium, phosphonium, and pyridinium cations yielded active pharmaceutical ingredient liquids (API-ILs) that show potent activities five different human cancer lines: T47D (breast), PC3 (prostate), HepG2 (liver), MG63 (osteosarcoma), RKO (colon). Some API-ILs showed IC50 values between 5 42 nM, stand in...
The exposure of both crop fields and humans to antibiotic-resistant bacteria in animal excreta is an emergent concern the One Health initiative. This study assessed contamination livestock manure from poultry, pig, dairy farms slaughterhouses Portugal with resistance determinants. profiles 331 Enterobacteriaceae isolates eight β-lactam (amoxicillin, cefoxitin, cefotaxime, cefpirome, aztreonam, ceftazidime, imipenem meropenem) five non-β-lactam antibiotics (tetracycline (TET),...
Extended-spectrum β-lactamases (ESBLs) prevalence was studied in the north of Portugal, among 193 clinical isolates belonging to citizens a district boundaries between this country and Spain from total 7529 strains. In present study we recovered some members Enterobacteriaceae family, producing ESBL enzymes, including Escherichia coli (67.9%), Klebsiella pneumoniae (30.6%), oxytoca (0.5%), Enterobacter aerogenes Citrobacter freundii (0.5%). β -lactamases genes blaTEM, blaSHV, blaCTX-M were...
Background/Objectives: Peptides from protein ingredients exhibit key biological activities, including antimicrobial, antihypertensive, antioxidant, anti-inflammatory, analgesic, and immunomodulatory effects. Aligning with the One Health approach, there is growing investment in promoting pet health well-being. As a result, sustainable functional are increasingly essential for food development. In this work, peptides derived lactoferrins of different mammalian species were synthesized their...
Ionic liquids derived from active pharmaceutical ingredients may open new perspectives towards low-cost rescuing of classical antimalarial drugs.
Obesity, favored by the modern lifestyle, acquired epidemic proportions nowadays. Obesity has been associated with various major causes of death and morbidity including malignant neoplasms. This increased prevalence accompanied a worldwide increase in cutaneous melanoma incidence rates during last decades. involvement aetiology recognized, but implicated mechanisms remain unclear. In present study, we address this relationship investigate influence adipocytes secretome on B16-F10 MeWo cell...
Antiepileptic drugs (AED) have been associated to in vivo deleterious consequences bone tissue. The present work aimed characterize the cellular and molecular effects of five different AED on human osteoclastogenesis osteblastogenesis. It was observed that had ability differentially modulate both processes, a way dependent identity dose AED. Shortly, valproic acid stimulated either osteoblastogenesis, whereas carbamazepine, gabapentin, lamotrigine revealed an opposite behavior; topiramate...