A5073444786- Ionic liquids properties and applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Chemical Synthesis and Reactions
- Chemical and Physical Properties in Aqueous Solutions
- Synthetic Organic Chemistry Methods
- Phenothiazines and Benzothiazines Synthesis and Activities
- Polyoxometalates: Synthesis and Applications
- Antibiotics Pharmacokinetics and Efficacy
- Asymmetric Synthesis and Catalysis
- Catalytic Alkyne Reactions
- Phase Equilibria and Thermodynamics
- Inorganic and Organometallic Chemistry
- Electrochemical sensors and biosensors
- Oxidative Organic Chemistry Reactions
- Carbon dioxide utilization in catalysis
- Metal-Catalyzed Oxygenation Mechanisms
- Multicomponent Synthesis of Heterocycles
- Essential Oils and Antimicrobial Activity
- Corrosion Behavior and Inhibition
- Crystallization and Solubility Studies
- Metal-Organic Frameworks: Synthesis and Applications
- Surfactants and Colloidal Systems
- Chemical Synthesis and Analysis
- Ferrocene Chemistry and Applications
- Molecular Junctions and Nanostructures
Universidade Nova de Lisboa
2013-2024
Rede de Química e Tecnologia
2013-2024
University of Lisbon
2020-2024
Centro Universitário da Cidade
2022
Universidade do Porto
2015
Polytechnic Institute of Porto
2011
Instituto de Engenharia de Sistemas e Computadores Microsistemas e Nanotecnologias
2008
Instituto Superior Técnico
2007
University of Aveiro
2005-2006
University of Belgrade
2000-2001
Plastics are very useful materials and present numerous advantages in the daily life of individuals society. However, plastics accumulating environment due to their low biodegradability rate, this problem will persist for centuries. Until recently, oceans were treated as places dispose litter, thus persistent substances causing serious pollution issues. Plastic microplastic waste has a negative environmental, social, economic impact, e.g., injury/death marine organisms entering food chain,...
The aggregation behavior in aqueous solution of a number ionic liquids was investigated at ambient conditions by using three techniques: fluorescence, interfacial tension, and (1)H NMR spectroscopy. For the first time, fluorescence quenching effect has been used for determination critical micelle concentrations. This study focuses on following liquids: [Cnmpy]Cl (1-alkyl-3-methylpyridinium chlorides) with different linear alkyl chain lengths (n=4, 10, 12, 14, 16, or 18), [C12mpip]Br...
Novel ionic liquids containing ampicillin as an active pharmaceutical ingredient anion were prepared with good yields by using a new, efficient synthetic procedure based on the neutralization of moderately basic ammonia solution different organic cation hydroxides. The relevant physical and thermal properties these novel also evaluated.
Antibacterial activities of novel Active Pharmaceutical Ingredient Ionic Liquids (API–ILs) based on ampicillin anion [Amp] have been evaluated. They showed growth inhibition and bactericidal properties some sensitive bacteria especially Gram-negative resistant when compared to the [Na][Amp] initial bromide chloride salts. For these studies were analysed minimum inhibitory concentration (MIC) (MBIC) against Escherichia coli ATCC 25922 Klebsiella pneumoniae (clinically isolated), as well Gram...
The preparation and characterization of ionic liquids organic salts (OSILs) that contain anionic penicillin G [secoPen] amoxicillin [seco-Amx] hydrolysate derivatives their in vitro antibacterial activity against sensitive resistant Escherichiacoli Staphylococcusaureus strains is reported. Eleven hydrolyzed β-lactam-OSILs were obtained after precipitation moderate-to-high yields via the neutralization basic ammonia buffer antibiotics with different cation hydroxide salts. minimum inhibitory...
Significant antiproliferative effects against various tumor cell lines were observed with novel ampicillin salts as ionic liquids. The combination of anionic appropriate ammonium, imidazolium, phosphonium, and pyridinium cations yielded active pharmaceutical ingredient liquids (API-ILs) that show potent activities five different human cancer lines: T47D (breast), PC3 (prostate), HepG2 (liver), MG63 (osteosarcoma), RKO (colon). Some API-ILs showed IC50 values between 5 42 nM, stand in...
Skin aging is a biological process influenced by intrinsic and extrinsic factors. The last ones, mainly exposure to UV radiation, increases reactive oxygen species (ROS) production leading loss of extracellular matrix, also enhanced enzymatic degradation matrix supporting molecules. Thus, with the growing demand for eco-friendly skin products, natural compounds extracted from brown seaweeds revealed be good candidates due their broad range bioactivities, especially as antioxidants. aim this...
As the development of novel antibiotics has been at a halt for several decades, chemically enhancing existing drugs is very promising approach to drug development. Herein, we report preparation twelve organic salts and ionic liquids (OSILs) from ciprofloxacin norfloxacin as anions with enhanced antimicrobial activity. Each one fluoroquinolones (FQs) was combined six different hydroxide cations in 93-100% yield through buffer-assisted neutralization methodology. Six those were isomorphous...
A sustainable organic synthetic methodology for the preparation of novel biocompatible ionic liquids (ILs) based on gluconate anion has been developed. Four functionalized methylimidazolium cations were efficiently combined with gluconic acid by acid-base neutralization reactions. All salts obtained as RTILs in high yields (92–98%) and purity levels. Proton Nuclear Magnetic Resonance (1H NMR) studies had proved correct cation/anion proportion (1:1) their chemical stability. These ILs can be...
The ever-increasing interest in keeping a young appearance and healthy skin has leveraged the skincare industry. This, coupled together with increased concern regarding safety of synthetic products, boosted demand for new safer natural ingredients. Accordingly, aim this study was to evaluate dermatological potential brown seaweed Carpomitra costata. antioxidant, anti-enzymatic, antimicrobial, photoprotective anti-inflammatory properties five C. costata fractions (F1–F5) were evaluated. ethyl...
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Aspergillus species are the primary cause of invasive aspergillosis, which afflicts hundreds thousands patients yearly, with high mortality rates. Amphotericin B is considered gold standard in antifungal drug therapy, due to its broad-spectrum activity and rarely reported resistance. However, low solubility permeability, as well considerable toxicity, challenge administration. Lipid formulations amphotericin have been used promote slow release diminish but these expensive adverse health...
Cr and Mo tetracarbonyl complexes bearing the diimine ligand N,N′-bis(ferrocenylmethylene)ethylenediamine (FcNN) have been prepared from M(CO)6. Two isomeric forms of (FcNN)Mo(CO)4, corresponding to cis,cis cis,trans geometries with respect CN bonds free ligand, were shown exist in a 1∶12.5 ratio by 1H NMR (NOE experiments). By contrast, only trans,trans isomer is observed for complex (FcNN)Cr(CO)4. The compounds (FcNN)M(CO)4 show ferrocene-based irreversible oxidation processes that lead...