A5006401610- Seaweed-derived Bioactive Compounds
- Marine Sponges and Natural Products
- Algal biology and biofuel production
- Echinoderm biology and ecology
- Protein Hydrolysis and Bioactive Peptides
- Marine and coastal plant biology
- Ion Transport and Channel Regulation
- Microbial Natural Products and Biosynthesis
- Aquaculture Nutrition and Growth
- Cholinesterase and Neurodegenerative Diseases
- Phytochemicals and Antioxidant Activities
- Bee Products Chemical Analysis
- Nanocomposite Films for Food Packaging
- Phytochemistry and Biological Activities
- Medicinal Plants and Neuroprotection
- Aquatic Ecosystems and Phytoplankton Dynamics
- Marine Biology and Environmental Chemistry
- Skin Protection and Aging
- Plant Growth Enhancement Techniques
- Essential Oils and Antimicrobial Activity
- Nitric Oxide and Endothelin Effects
- Ionic liquids properties and applications
- Macrophage Migration Inhibitory Factor
- Aquatic life and conservation
- Marine Ecology and Invasive Species
Instituto Politécnico de Leiria
2015-2024
Aquatic Systems (United States)
2023-2024
Research Network (United States)
2024
MARE - Centro de Ciências do Mar e do Ambiente
2022
Universidade de Santiago de Compostela
2021
University of Lisbon
2021
Marine Research Centre
2021
Instituto de Pesca
2021
Universidade do Porto
2002-2019
Instituto Politécnico Nacional
2015
Chitin was extracted from Polybius henslowii, a swimming crab, captured in large quantities throughout the Portuguese coast by purse seine vessels as bycatch. After standard chitin extraction procedures, water-soluble chitosan products were obtained via two different methods: (1) N-acetylation with addition of acetic anhydride and (2) reaction hydrogen peroxide. The chemical structure molecular weight derivatives, (WSC) chitooligosaccharides (COS), confirmed Fourier Transform Infrared...
This study assessed the antioxidant, antimicrobial, anticancer and neuroprotective activities of kappa(k)-carrageenan isolated from red alga Hypnea musciformis (Hm-SP). The chemical spectrum k-carrageenan Hm-SP was confirmed by Fourier transform infrared (FT-IR) spectroscopy. revealed an antibacterial antifungal action against Staphylococcus aureus Candida albicans, respectively. did not promoted cytotoxic effects Human breast cancer (MCF-7) neuroblastoma (SH-SY5Y) cell-lines. However, it...
Bifurcaria bifurcata is a marine brown seaweed mainly found on the Atlantic coast. Herein, we report antioxidant and neuroprotective activities of seven fractions (F1⁻F7) obtained by normal phase chromatography from B. dichloromethane extract, as well its two major isolated diterpenes. Total phenolic content was determined Folin⁻Ciocalteu method, while activity evaluated DPPH, ORAC, FRAP assays. Neuroprotective effects were in neurotoxic model induced 6-hydroxydopamine (6-OHDA) human...
Parkinsons Disease (PD) is the second most common neurodegenerative disease worldwide, and characterized by a progressive degeneration of dopaminergic neurons. Without an effective treatment, it crucial to find new therapeutic options fight process, which may arise from marine resources. Accordingly, goal present work was evaluate ability monoterpenoid lactone Loliolide, isolated green seaweed Codium tomentosum, prevent neurological cell death mediated neurotoxin 6-hydroxydopamine (6-OHDA)...
Cancer and infectious diseases continue to be a major public health problem, new drugs are necessary. As marine organisms well known provide wide range of original compounds, the aim this study was investigate bioactivity main constituents cosmopolitan red alga, Sphaerococcus coronopifolius. The structure several bromoditerpenes determined by extensive spectroscopic analysis comparison with literature data. Five molecules were isolated characterized which include brominated diterpene...
Skin aging is a biological process influenced by intrinsic and extrinsic factors. The last ones, mainly exposure to UV radiation, increases reactive oxygen species (ROS) production leading loss of extracellular matrix, also enhanced enzymatic degradation matrix supporting molecules. Thus, with the growing demand for eco-friendly skin products, natural compounds extracted from brown seaweeds revealed be good candidates due their broad range bioactivities, especially as antioxidants. aim this...
Luteolin is one of the most common flavonoids present in edible plants and its potential benefits to central nervous system include decrease microglia activation, neuronal damage high antioxidant properties. The aim this research was evaluate neuroprotective, anti-inflammatory activities luteolin-7-O-glucoside (Lut7). Undifferentiated retinoic acid (RA)-differentiated SH-SY5Y cells were pretreated with Lut7 incubated 6-hydroxydopamine (6-OHDA). Cytotoxic neuroprotective effects determined by...
The present study was designed to evaluate the nature of intervening agents in L ‐DOPA‐ and dopamine‐induced neurotoxicity Neuro‐2A cells. In absence cells conditions light protection, at 37°C, ‐DOPA or dopamine (1 m M ) culture medium degraded spontaneously a time‐dependent manner, this being prevented by ascorbic acid (200 μ other antioxidants, namely glutathione ), N‐acetyl‐ ‐cysteine sodium metabisulphite but not N‐ter‐butyl‐α‐phenylnitrone deferoxamine (100 ). viability declined...
Surface-associated marine bacteria are an interesting source of new secondary metabolites. The aim this study was the isolation and identification epiphytic from brown alga, Bifurcaria bifurcata, evaluation antioxidant antimicrobial activity extracts. determined by 16S rRNA gene sequencing. Bacteria extracts were obtained with methanol dichloromethane (1:1) extraction. performed quantification total phenolic content (TPC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging oxygen...
Parkinson's disease (PD) is a progressive neurodegenerative disorder of the central nervous system. Although causes PD pathogenesis remain incomplete, some evidences has suggested that oxidative stress an important mediator in its pathogenesis. The aim this study was to evaluate protective effects seaweeds with high antioxidant activity on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity human neuroblastoma cell line SH-SY5Y, as well associated intracellular signaling pathways. Cell...
The growing search for natural alternatives to synthetic food packaging materials and additives has increased, seaweed extracts’ bioactivity made them suitable candidates incorporation in novel edible films. This study aims investigate the effect of Codium tomentosum extract (SE) alginate chitosan Alginate- chitosan-based films with without 0.5% SE were characterized according their physical, optical, mechanical, thermal properties. Seaweed resulted an increase film solubility (50%),...
As the development of novel antibiotics has been at a halt for several decades, chemically enhancing existing drugs is very promising approach to drug development. Herein, we report preparation twelve organic salts and ionic liquids (OSILs) from ciprofloxacin norfloxacin as anions with enhanced antimicrobial activity. Each one fluoroquinolones (FQs) was combined six different hydroxide cations in 93-100% yield through buffer-assisted neutralization methodology. Six those were isomorphous...
In the pursuit of sustainability and circularity, this study aimed to develop a multi-purpose biorefinery pipeline using extracts from green seaweed Codium sp. transforming its post-extracted biomass into biochars, emphasizing holistic resource utilization. Five were evaluated, testing their antioxidant potential, cytotoxicity, photoprotective effects, anti-inflammatory activity, inhibitory capabilities against enzymes hyaluronidase, collagenase, elastase. The ethyl acetate extract showed...
The efficacy of anaesthetic tricaine methanesulfonate (MS-222) was evaluated in four freshwater aquarium fish species, Zebrafish (Danio rerio), Guppy (Poecilia reticulata), Discu (Symphysodon discus) and Green swordtail (Xiphophorus helleri). correct dose should induce the plane 4 anaesthesia less than 180 s, recovery 300 s must survive when exposed during 30 min to anaesthetic. Fishes were six concentrations (75, 100, 125, 150, 200 250 mg L−1) time reaching anaesthesia, post exposure...
Sea cucumbers are highly marketable as a food product due to their nutritional value. Also, it has been suggested that sea possess wide range of bioactive compounds can be used in the pharmaceutical industry. In this study, reproductive biology Holothuria forskali was performed by evaluating gonadosomatic index (GI) and histological analyses gonadal tubules. The biotechnological potential assessed through evaluation antioxidant, antimicrobial antitumor potential. Finally, fatty acid profile...