A5069768951- Malaria Research and Control
- Phenothiazines and Benzothiazines Synthesis and Activities
- Research on Leishmaniasis Studies
- Metal complexes synthesis and properties
- Crystallization and Solubility Studies
- Click Chemistry and Applications
- Trypanosoma species research and implications
- HIV/AIDS drug development and treatment
- X-ray Diffraction in Crystallography
- Synthesis and biological activity
- Mosquito-borne diseases and control
- Venomous Animal Envenomation and Studies
- Synthesis and bioactivity of alkaloids
- Brucella: diagnosis, epidemiology, treatment
- Reproductive System and Pregnancy
- Food Quality and Safety Studies
- Immunotherapy and Immune Responses
- Ferrocene Chemistry and Applications
- Ionic liquids properties and applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Metabolism and Genetic Disorders
- Insect Pest Control Strategies
- Parasites and Host Interactions
- Phytochemistry and Bioactivity Studies
- Drug Transport and Resistance Mechanisms
Universidade Nova de Lisboa
2013-2025
Instituto de Investigação Científica Tropical
2015
Eduardo Mondlane University
2015
University of Lisbon
2015
Universidade Federal do Rio Grande do Norte
2012
The prophylactic and therapeutic arsenal against malaria is quite restricted all the antimalarials currently in use have limitations. Thus, there a need to investigate medicinal plants search for phytochemicals which can be developed into drugs. In our investigation, essential oils (EOs) were obtained from Vanillosmopsis arborea (Gardner) Baker, Lippia sidoides Cham. Croton zehntneri Pax & K. Hoffm., aromatic abundant northeastern Brazil, are found caatinga region used traditional medicine....
Dendritic cells (DCs) capture pathogens and process antigens, playing a crucial role in activating naïve T cells, bridging the gap between innate acquired immunity. However, little is known about DC activation when facing
Leishmaniasis is a group of parasitic diseases whose etiological agent the protozoa Leishmania . These afflict impoverished populations in tropical and subtropical regions affect wild domestic animals. Canine leishmaniasis global disease mostly caused by L. infantum Dogs are recognized as good reservoir since harbor infection long before developing disease, facilitating parasite transmission. Furthermore, there growing evidence that dogs may also be American spp. amazonensis The innate...
We report the presence of SNPs in Plasmodium falciparum K13-propeller gene two African countries, Angola and Mozambique, where malaria is a serious public health problem. Samples were collected before after ACT introduction as first-line treatment. In each country 50 samples analysed. A total three different mutations (R471R R575R V494I Mozambique) identified five samples, all ACT. The R471R mutation detected has already been reported Africa (DR-Congo Gabon). However, (Angola) (Mozambique),...
Mozambique implemented artemisinin-based combinations therapy (ACT) using artemether-lumefantrine (AL) as the first-line treatment for uncomplicated malaria in 2009. AL remains highly efficacious, but widespread use may soon facilitate emergence of artemisinin tolerance/resistance. The prevalence pfmdr1 different alleles Maputo and is not known, either after or before introduction ACT. Pfmdr1 molecular markers related to Plasmodium falciparum susceptibility were analysed transition A first...
The emergence and spread of Plasmodium falciparum resistance to artemisinin-based combination therapy in Southeast Asia prompted the need develop new endoperoxide-type drugs.A chemically diverse library endoperoxides was designed synthesized. compounds were screened for vitro vivo anti-malarial activity using, respectively, SYBR Green I assay a mouse model. Ring survival mature stage assays performed against artemisinin-resistant artemisinin-sensitive P. strains. Cytotoxicity evaluated...
Ionic liquids derived from classical antimalarials are emerging as a new approach towards the cost-effective rescuing of those drugs. Herein, we disclose novel surface-active ionic chloroquine and natural fatty acids whose antimalarial activity in vitro was found to be superior that parent drug. The most potent liquid laurate salt chloroquine, which presented IC50 values 4 110 nM against chloroquine-sensitive chloroquine-resistant strain Plasmodium falciparum, respectively, corresponding an...
Recent publications report in vitro activity of quinolone 3-esters against the bc1 protein complex Plasmodium falciparum and parasite. Docking studies performed silico at yeast Qo site established a key role for 4-oxo N–H groups drug-target interactions. Thus, possibility 4-oxoquinoline/4-hydroxyquinoline tautomerism may impact pharmacologic profiles should be investigated. We describe synthesis, structure, photochemistry, multidrug-resistant P. strain Dd2 ethyl...
Abstract In a follow‐up study to our reports of N‐cinnamoylated chloroquine and quinacrine analogues as promising dual‐stage antimalarial leads with high in vitro potency against both blood‐stage Plasmodium falciparum liver‐stage berghei , we decided investigate the effect replacing cinnamoyl moiety other acyl groups. Thus, series N‐acylated were synthesized, their activities blood‐ spp. assessed along cytotoxicities. Although new found be somewhat less active more cytotoxic than...
A small library of "half-sandwich" cyclopentadienylruthenium(II) compounds the general formula [(η5-C5R5)Ru(PPh3)(N-N)][PF6], a scaffold hitherto absent from toolbox antiplasmodials, was screened for activity against blood stage CQ-sensitive 3D7-GFP, CQ-resistant Dd2, and artemisinin-resistant IPC5202 Plasmodium falciparum strains liver berghei. The best-performing displayed dual-stage activity, with single-digit nanomolar IC50 values blood-stage malaria parasites, liver-stage residual...
Background Delayed Plasmodium falciparum parasite clearance has been associated with Single Nucleotide Polymorphisms (SNPs) in the kelch protein propeller domain (coded by pfk13 gene). SNPs multidrug resistance gene 1 ( pfmdr1) are multi-drug including combination artemether-lumefantrine. To our knowledge, this is first work providing information on prevalence of k13-propeller and pfmdr1 mutations from Sédhiou, a region south Senegal. Methods 147 dried blood spots filter papers were...
Plasmodium falciparum has shown multidrug resistance, leading to the necessity for development of new drugs with novel targets, such as synthesis isoprenic precursors, which are excellent targets because pathway is different in several steps when compared human host. Naphthoquinone derivatives have been described potentially promising anti-malarial leader molecules. In view that, focus this work twofold: first, evaluate vitro naphthoquinone antiplasmodial activity and cytotoxicity; secondly,...
Ever increasing multi-drug resistance by Plasmodium falciparum is creating new challenges in malaria chemotherapy. In the absence of licensed vaccines, treatment and prevention heavily dependent on drugs. Potency, range activity, safety, low cost ease administration are crucial issues design formulation antimalarials. We have tested three synthetic ozonides NAC89, LC50 LCD67 vitro vivo against multidrug resistant Plasmodium. vitro, was at least 10 times more efficient inhibiting P. Dd2...
Plasmodium falciparum causes the most severe/lethal form of malaria, a parasitic infection that affects 500 million people worldwide and leads to death nearly one million/year, about 91% being due P. . The malaria pigment or hemozoin crystals (HZ) are formed in an enzyme-independent polymerization heme released during haemoglobin digestion by parasite intra-erythrocytic life cycle. quinoline artemisinin based antimalarials (the only available treatment options) appear act disrupting...
A small library of “half-sandwich” cyclopentadienylruthenium(II) compounds general formula [(η 5 -C R )Ru(PPh 3 )(N-N)][PF 6 ], a scaffold hitherto unfeatured in the toolbox antiplasmodials, was screened for activity against blood stage CQ-sensitive 3D7-GFP, CQ-resistant Dd2 and artemisinin-resistant IPC5202 Plasmodium falciparum strains, liver P. berghei . The best performing displayed dual-stage activity, with single-digit nM IC 50 values malaria parasites, residual cytotoxicity mammalian...
<p><a>A small library of “half-sandwich” cyclopentadienylruthenium(II) compounds general formula [(</a>η<sup>5</sup>-C<sub>5</sub>R<sub>5</sub>)Ru(PPh<sub>3</sub>)(N-N)][PF<sub>6</sub>], a scaffold hitherto unfeatured in the toolbox antiplasmodials, was screened for activity against blood stage CQ-sensitive 3D7-GFP, CQ-resistant Dd2 and artemisinin-resistant IPC5202 <i>Plasmodium falciparum</i> strains,...