A5069698417- Ocular Surface and Contact Lens
- Lipid Membrane Structure and Behavior
- Surfactants and Colloidal Systems
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Ocular Infections and Treatments
- Advancements in Transdermal Drug Delivery
- Photochemistry and Electron Transfer Studies
- Advanced Drug Delivery Systems
- Protein Interaction Studies and Fluorescence Analysis
- Spectroscopy and Quantum Chemical Studies
- Corneal surgery and disorders
- DNA and Nucleic Acid Chemistry
- Graphene and Nanomaterials Applications
- Analytical Chemistry and Chromatography
- Immunotherapy and Immune Responses
- Corneal Surgery and Treatments
- Nanopore and Nanochannel Transport Studies
- MicroRNA in disease regulation
- Intraocular Surgery and Lenses
- Advanced Biosensing Techniques and Applications
- Computational Drug Discovery Methods
- Dyeing and Modifying Textile Fibers
- Ophthalmology and Visual Impairment Studies
University of Minho
2015-2025
University of Cuenca
2018
Moscow Engineering Physics Institute
2018
Clinical Academic Center of Braga
2016
Universidade de Santiago de Compostela
2007-2008
Universidade Estadual Paulista (Unesp)
2006
Universidade Estadual de Campinas (UNICAMP)
2006
University of Coimbra
2002
Seventy-five patients with hemoptysis were treated bronchial artery embolization (BAE). The procedure was performed Hexabrix (sodium methylglucamine ioxaglate), Mikaelson catheters, and Gelfoam particles. Angiographic evaluation of the anatomy revealed ten different configurations, which are described. attempt failed in three cases (4%); eight additional (10.7%) excluded from series because inadequate data. In remaining 64 patients, 41 underwent BAE alone 23 either chemotherapy or surgery...
Purpose. The purpose of this study is to compare the adhesion capabilities most important etiologic agents microbial ocular infection recently available silicone–hydrogel lenses with those a conventional hydrogel lens. Methods. In vitro static assays Pseudomonas aeruginosa 10,145, Staphylococcus epidermidis 9142 (biofilm-positive), and 12,228 (biofilm-negative) two extended-wear (balafilcon A lotrafilcon A), daily wear lens (galyfilcon A) (etafilcon were performed. To interpret results,...
This study was designed to assess whether hydrogel contact lens (CL) surface hydrophobicity and roughness affect Staphylococcus epidermidis adhesion.Bacterial adhesion experiments were performed on two unworn silicone three conventional CLs using the S.epidermidis strain CECT 4184. Microbial colonization assessed by conducting counts expressed as colony-forming units. CL determined through water angle measurements parameters such mean (Ra), kurtosis (Rku), skewness (Rsk) atomic force...
HIV/AIDS stands as a global burden, and vaginal microbicides constitute promising strategy for topical pre-exposure prophylaxis. Preceding the development of microbicide containing tenofovir disoproxil fumarate (TDF) emtricitabine (FTC), in silico vitro studies were performed to evaluate physicochemical characteristics both drugs, study their biophysical impact lipid model systems. Results from these pre-formulation defined hydrogels adequate vehicles incorporate TDF-loaded liposomes FTC....
Introduction: The development of novel drug carriers is invaluable to maximize therapeutic efficiency and improve specificity. Dioctadecyl-dimethylammonium bromide (DODAB): monoolein (MO) (1:2) liposomes exhibit non-lamellar phases in their core that the encapsulation ability both hydrophobic hydrophilic molecules. This study explores use this nanosystem for delivery cytokines, specifically leukemia inhibitory factor (LIF). Nanocarriers can overcome drawbacks direct cytokine administration,...
Abstract Purpose: The aim of this study was to analyze surface changes three silicone‐hydrogel contact lenses after daily wear. used in were balafilcon A, lotrafilcon B (both surface‐treated), and galyfilcon A (non surface‐treated). Methods: To understand how where proteins, lipids, other contaminants change lenses, roughness assessed through Atomic Force Microscopy Tapping Mode™. Roughness parameters Mean Surface ( R a ), Mean‐square‐roughness q Maximum max ). topography unworn worn also...
This study was designed to qualitatively and quantitatively characterize the surface morphology of four unworn conventional hydrogel contact lenses (omafilcon, hioxifilcon, nelfilcon A, ocufilcon B) two silicone-hydrogel (senofilcon A comfilcon A) without treatment.Surface roughness assessed using atomic force microscopy in Tapping Mode determine representative parameters mean (Ra), square (Rms), kurtosis (Rku), skewness (Rsk). To date, these last have not been used lens surfaces. Rku...
This study describes a novel liposomal formulation for siRNA delivery, based on the mixture of neutral lipid monoolein (MO) and cationic lipids dioctadecyldimethylammonium (DODA) family. The bromide (DODAB) chloride (DODAC) were compared in order to identify which one will most efficiently induce gene silencing. MO has fluidizing effect DODAC DODAB liposomes, although it was more homogeneously distributed bilayers. All MO-based formulations able encapsulate siRNA. Stable lipoplexes small...
Posterior eye disorders, such as age-related macular degeneration, diabetic retinopathy, and glaucoma, have a significant impact on human quality of life are the primary cause retinal diseases among adults. There is pressing need for innovative topical approaches to treat posterior current methods often rely invasive procedures with inherent risks. Limited success was attained in realm ophthalmic delivery through non-invasive means. Additionally, there exists dearth literature that delves...
The lipid/surfactant mixed interactions between the lipid dipalmitoylphosphatydilcholine (DPPC) and nonionic surfactant C12E7 (C12H25(OCH2CH2)7OH) were studied by use of fluorescence anisotropy nile red DCM laser dye. Three different regions consisting micelles, vesicles, both aggregates identified. Nile is wavelength-dependent, spectra being decomposed into two log-normal functions. These results are consistent with a solvent relaxation process, distinct anisotropies for relaxed unrelaxed...
The thermotropic phase behavior of cationic liposomes in mixtures two the most investigated liposome-forming double-chain lipids, dioctadecyldimethylammonium bromide (DODAB) and didodecyldimethylammonium (DDAB), was by differential scanning calorimetry (DSC), turbidity, Nile Red fluorescence. dispersions were at 1.0 mM total surfactant concentration varying DODAB DDAB concentrations. gel to liquid-crystalline transition temperatures (Tm) neat aqueous are around 16 43 degrees C, respectively,...
Diclofenac (DCF), the most widely consumed non-steroidal anti-inflammatory drug (NSAID) worldwide, is associated with adverse typical effects, including gastrointestinal (GI) complications. The present study aims to better understand topical toxicity induced by DCF using membrane models that mimic physiological, biophysical, and chemical environments of GI mucosa segments. For this purpose, phospholipidic model systems protective lining lipid inner mitochondrial were used together a wide set...
In this work ternary systems of the nonionic surfactant C12E5 (C12H25(OCH2CH2)5OH), tetradecane, and water were probed by use steady state time-resolved fluorescence. Microemulsions, which rich in oil, water, also both continuous oil monitored via application solvatochromic fluorescent probes. The hydrophobic laser dye Nile Red was used to report from side oil−surfactant interface, while Prodan, is soluble each constituent solvents, provide a global picture. To complement these, hydrophilic...
Purpose. The aim of this study was to, firstly, investigate whether silicone-hydrogel contact lenses (CL) are more or less susceptible to bacterial adhesion than conventional ones and, secondly, assess the influence lens wear in extent adhesion. Four CL (galyfilcon A, balafilcon lotrafilcon and B) one hydrogel (etafilcon A) were tested. Methods. Bacterial experiments performed on unworn worn using strain Staphylococcus epidermidis 9142. Worn obtained from a group 31 subjects fitted with eye...
Purpose: The aim of the present study was to analyse quality and quantity tear film in a young, healthy non‐contact lens‐wearing population with measurements taken morning afternoon establish if changes exist these parameters.Methods: In controlled laboratory setting, clinical parameters were assessed. Schirmer test, meniscus height, break‐up time non‐invasive measured 51 normal subjects on same day for each individual.Results: Tear volume showed no significant during but stability...