A5007415310- Ocular Surface and Contact Lens
- Ocular Infections and Treatments
- Biochemical effects in animals
- Bone health and osteoporosis research
- Corneal surgery and disorders
- Bone Metabolism and Diseases
- Muscle Physiology and Disorders
- Nutrition and Health in Aging
- Bone fractures and treatments
- Advancements in Transdermal Drug Delivery
- Surfactants and Colloidal Systems
- Muscle metabolism and nutrition
- Diet and metabolism studies
- Corneal Surgery and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Intraocular Surgery and Lenses
- Aldose Reductase and Taurine
- Laser Applications in Dentistry and Medicine
- Bone health and treatments
- Mesenchymal stem cell research
- Caveolin-1 and cellular processes
- Facial Rejuvenation and Surgery Techniques
- Genetics, Aging, and Longevity in Model Organisms
Nottingham Trent University
2017-2025
University of Minho
2006-2016
Imperial College London
2014-2015
NIHR Imperial Biomedical Research Centre
2014-2015
Institute for Biotechnology and Bioengineering
2007-2011
Universidade do Porto
2011
Universidade de Santiago de Compostela
2007-2008
With ageing, bone tissue undergoes significant compositional, architectural and metabolic alterations potentially leading to osteoporosis. Osteoporosis is the most prevalent disorder, which characterised by progressive weakening an increased risk of fragility fractures. Although this disease conventionally associated with ageing menopause, predisposing factors are thought be established during childhood adolescence. In light this, exercise interventions implemented maturation likely highly...
Abstract Objective Overweight and obesity are characterized by excess adiposity systemic, chronic, low‐grade inflammation, which is associated with several metabolic disorders. The aim of this study was to assess the feasibility tolerability β‐alanine supplementation explore effects on cardiometabolic health cardiovascular, hepatic, renal function in adults overweight obesity. Methods A total 27 (44% female; mean [SD], age: 58 [10] years, BMI: 31.1 [2.9] kg/m 2 , hemoglobin A1c: 39.8 [4.3]...
Abstract Purpose: The aim of this study was to analyze surface changes three silicone‐hydrogel contact lenses after daily wear. used in were balafilcon A, lotrafilcon B (both surface‐treated), and galyfilcon A (non surface‐treated). Methods: To understand how where proteins, lipids, other contaminants change lenses, roughness assessed through Atomic Force Microscopy Tapping Mode™. Roughness parameters Mean Surface ( R a ), Mean‐square‐roughness q Maximum max ). topography unworn worn also...
Embryonic stem cells (ESCs) can differentiate into all cell types of the body and, therefore, hold tremendous promise for cell-based regenerative medicine therapies. One significant challenge that should be addressed before using ESCs in clinic is to improve methods efficiently and effectively directing differentiation this heterogeneous population. The work presented here examines potential harnessing naturally derived extracellular vesicles deliver genetic material from mature...
Angiogenesis, the formation of blood vessels from pre-existing ones, is vital importance during early stages bone healing. Extracellular stiffness plays an important role in regulating endothelial cell behavior and angiogenesis, but how this mechanical cue affects proliferation kinetics, gene regulation, expression proteins implicated angiogenesis regeneration remains unclear. Using collagen-coated polyacrylamide (PAAm) hydrogels, human umbilical vein cells (HUVECs) are exposed to...
The integrity and function of the periodontium can be compromised by traumatic injuries or periodontitis. Currently available clinical therapies are able to stop progression periodontitis allow healing periodontal tissue. However, an optimal strategy capable restoring anatomy functionality lost tissue is still achieved. Herein proposed development injectable hydrogel system release a growth factors cells defect. This based on photocrosslinkable hydrogel, prepared from methacrylated...
Type-2 diabetes (T2D) is characterised by a dysregulation of metabolism, including skeletal muscle insulin resistance, mitochondrial dysfunction, and oxidative stress. Reactive species, such as methylglyoxal (MGO) 4-hydroxynonenal (4-HNE), positively associate with T2D disease severity can directly interfere signalling glucose uptake in modifying cellular proteins. The multifunctional dipeptide carnosine, its rate-limiting precursor β-alanine, have recently been shown to improve glycaemic...
Purpose. The aim of this study was to, firstly, investigate whether silicone-hydrogel contact lenses (CL) are more or less susceptible to bacterial adhesion than conventional ones and, secondly, assess the influence lens wear in extent adhesion. Four CL (galyfilcon A, balafilcon lotrafilcon and B) one hydrogel (etafilcon A) were tested. Methods. Bacterial experiments performed on unworn worn using strain Staphylococcus epidermidis 9142. Worn obtained from a group 31 subjects fitted with eye...
Objectives: Menstrual cups come in a range of shapes, sizes, and firmnesses, but unlike tampons are not categorized any way. With these factors having an impact on product leaks comfort, as well being linked to illness injury, women need the same level transparency when purchasing menstrual cup. The comparison physical mechanical properties will be first step achieve this. Methods: In October 2020, 14 popular highly rated underwent quantitative laboratory settings (the United Kingdom), they...
To evaluate the influence of wear silicone-hydrogel contact lenses on lens ultraviolet and visible spectrum transmittance by studying several before after wear.To investigate ability to maintain their characteristics, we measured 104 different in (UV) range from 200 700 nm, with a Shimadzu UV3101-PC UV-vis-NIR spectrophotometer equipped an integrating sphere. The used this study were Acuvue Advance (Johnson & Johnson Vision Care, Inc.), Air Optix Night Day (CIBA Vision), PureVision (Bausch...
Aim: To expand our understanding on the effect of magnetically actuated biomaterials in stem cells, inflammation and fibrous tissue growth. Materials & methods: Magnetic were obtained by doping iron oxide particles into starch poly-ϵ-caprolactone (SPCL) to create two formulations, magSPCL-1.8 3.6. Stem cell behavior was assessed vitro inflammatory response, subcutaneously Wistar rats. Results: Metabolic activity proliferation increased significantly overtime SPCL magSPCL-1.8. Electromagnetic...
Patients with dry eye syndrome, Stevens-Johnson or recurrent transplant rejections are unsuitable to receive a keratoprosthesis. The present work aims at developing highly biocompatible keratoprosthesis that could be successfully implanted in such patients.Glass-reinforced hydroxyapatite (GRHA) was used construct this new artificial cornea. To grant the device an adequate porosity, porogen agent added following percentages: 10, 30, and 50%. Samples were physicochemically analyzed terms of...
Sarcopenia is an age-related muscle disease that increases the risk of falls, disabilities, and death. It associated with increased protein degradation driven by molecular signalling pathways including Akt FOXO1. This study aims to identify genes, gene interactions, processes aging exercise in older adults remained undiscovered until now leveraging on artificial intelligence approach called neural network inference (ANNi).
Intermittent and continuous mechanical loads are known to influence osteogenic activity. The present study examines the effects of matched intermittent load in vitro on bone formation markers. MC3T3 (mouse pre-osteoblasts) were cultured placed a bioreactor undergo continuous, intermittent, or unloading for 1, 3 12 days. Loading conditions magnitude, duration frequency. Each time point was analysed alkaline phosphatase (ALP) activity, procollagen 1 N-terminal propeptide (PINP) alizarin red...
Purpose. In this study, the effect of natural surfactants octylglucoside and sodium cholate in inhibiting Staphylococcus epidermidis Pseudomonas aeruginosa adhesion to conventional silicone-hydrogel contact lenses (CL) was assessed. Hydrophobicity also evaluated conditioned nonconditioned CL. Methods. The tested determined through “in vitro” studies CL followed by image acquisition cell enumeration. angle measurements using advancing type technique on air. Results. Sodium exhibits a very low...
To test whether high circulating insulin concentrations influence the transport of β-alanine into skeletal muscle at either saturating or subsaturating concentrations, we conducted two experiments whereby and were controlled. In experiment 1, 12 men received supraphysiological amounts intravenously (0.11 g·kg-1·min-1 for 150 min), with without infusion. β-Alanine carnosine measured in before 30 min after Blood samples taken throughout infusion protocol plasma analyses. content 24-h urine was...
Abstract Exercise is a non-pharmacological intervention that can enhance bone regeneration and improve the management of conditions like osteoporosis or metastatic cancer. Therefore, it gaining increasing importance in an emerging area regenerative medicine—regenerative rehabilitation (RR). Osteocytes are mechanosensitive secretory cells orchestrate anabolism hence postulated to be attractive target exercise interventions. However, human osteocyte signalling pathways processes evoked upon...