A5010404549- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- Dental materials and restorations
- Bacterial biofilms and quorum sensing
- Graphene and Nanomaterials Applications
- biodegradable polymer synthesis and properties
- Orthopedic Infections and Treatments
- Silk-based biomaterials and applications
- Orthopaedic implants and arthroplasty
- Electrospun Nanofibers in Biomedical Applications
- Oral microbiology and periodontitis research
- Climate Change and Health Impacts
- Antimicrobial Resistance in Staphylococcus
- Collagen: Extraction and Characterization
- Bacteriophages and microbial interactions
- Nanoparticles: synthesis and applications
- 3D Printing in Biomedical Research
- RNA Interference and Gene Delivery
- Antifungal resistance and susceptibility
- Global Health Care Issues
- Periodontal Regeneration and Treatments
- Bone and Dental Protein Studies
- Endodontics and Root Canal Treatments
- Food Waste Reduction and Sustainability
- Global Energy and Sustainability Research
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2015-2025
Universidade do Porto
2012-2025
Ludwig-Maximilians-Universität München
2024
LMU Klinikum
2024
National Institute of Engineering, Technology and Innovation
2013-2023
Opto Eletrônica (Brazil)
2023
Fernando Pessoa University
2012-2021
Institute of Mechanical Engineering and Industrial Mangement
1999-2007
The world population is ageing, in particular the developed world, with a significant increase percentage of people above 60 years old. They represent segment that more vulnerable to adverse environmental conditions. Among them, indoor air quality one most relevant, as elders spend comparatively time indoors than younger generations. Furthermore, recent COVID-19 pandemic contributed immensely raising awareness importance breathing for human health and fact vector airborne infections...
Presently, millions worldwide suffer from degenerative and inflammatory bone joint issues, comprising roughly half of chronic ailments in those over 50, leading to prolonged discomfort physical limitations. These conditions become more prevalent with age lifestyle factors, escalating due the growing elderly populace. Addressing these challenges often entails surgical interventions utilizing implants or grafts, though treatments may entail complications such as pain tissue death at donor...
Abstract Severe periodontitis treatment, where massive alveolar bone loss occurs, involves defect filling and intensive systemic log‐term antibiotics administration. This study aims at developing novel injectable drug delivery systems (nanohydroxyapatite microspheres) with the releasing capability for treatment simultaneously initiating osteointegration process. Materials were characterized by XRD, SEM, inverted stand optical microscope analysis, mercury porosimetry method. Amoxicillin,...
Ceramic scaffolds are widely studied in the bone tissue engineering field due to their potential regenerative medicine. However, adhesion of microorganisms on biomaterials with subsequent formation antibiotic-resistant biofilms is a critical factor implant-related infections. Therefore, new strategies needed address this problem. In present study, three-dimensional and interconnected porous granules nanostructured hydroxyapatite (nanoHA) incorporated different amounts zinc oxide (ZnO)...
Abstract This study concerns the preparation, physical, and in vitro characterization of two different types hydroxyapatite (HA) microspheres, which are intended to be used as drug‐delivery systems bone‐regeneration matrices. Hydroxyapatite nanoparticles (HA‐1 HA‐2) were prepared using chemical precipitation synthesis with H 3 PO 4 , Ca(OH) 2 a surfactant, SDS (sodium dodecyl sulfate), starting reagents. The HA powders dispersed sodium alginate solution, spherical particles obtained by...
A novel bioactive bone substitute with improved osteoblastic performance and effective antibacterial activity was developed, using a completely new approach based on samarium (Sm3+) doped P2O5 glass-reinforced hydroxyapatite composites (GR-HA). The were prepared by adding 2.5% (w/w) of the glass to 97.5% HA. Four i.e. one non-doped composite, three Sm3+ containing 0.5, 1 2 (mol%) Sm2O3. labeled as GR-HA_control, GR-HA_0.5Sm, GR-HA_1Sm GR-HA_2Sm. physicochemical mechanically characterized,...
The aim of this work was to develop a bioactive bone substitute with an effective antibacterial ability based on cerium (Ce) doped glass-reinforced hydroxyapatite (GR-HA) composite. Developed composites were physicochemically characterized, using x-ray diffraction (XRD) analysis, SEM, energy dispersive spectroscopy (EDS), and flexural bending strength (FBS) tests. X-ray photoelectron (XPS) analysis performed analyze the oxidation state Ce in prepared glass. antimicrobial activity evaluated...
Biofilm-associated infections present a significant challenge in modern medicine, primarily due to their resilience and resistance conventional treatments. These occur when bacteria form biofilms, protective layers formed by bacterial communities, which are notoriously resistant traditional antibiotics on surfaces such as medical implants biological surfaces, making eradication with standard difficult. This leads persistent infections, imposing substantial economic burden healthcare systems....
Wound management presents a significant clinical challenge due to the rising prevalence of chronic wounds caused by conditions such as venous insufficiency, diabetes, and obesity, alongside acute injuries surgical wounds. This review provides comprehensive analysis key materials used in wound dressings, contextualizing their origin, chemical structure, intrinsic properties while emphasizing roles promoting healing. Particular attention is given materials’ capacity stimulate regeneration...
Developing innovative approaches to target osteomyelitis caused by polymicrobial infections remains a significant therapeutic challenge. In this study, monodispersed chitosan nanoparticles co-loaded with antibacterial (minocycline) and antifungal (voriconazole) agents were successfully prepared. Minocycline presented higher encapsulation efficiency as compared voriconazole. Thermostability analysis suggested interactions between the drugs within dual-delivery system, potentially limiting...
Abstract During the last decades, different materials of both natural and synthetic origin have been developed with aim inducing controlling osteogenic differentiation mesenchymal stem cells (MSCs). In order for that to happen, it is necessary material be implanted obey a series requirements, namely: osteoconduction, biocompatibility, biodegradability. Additionally, they must low‐priced, easy produce, shape, store. Hydroxyapatite (HA) well known ceramic composition similar mineral component...
Equisetum arvense preparations have long been used to promote bone healing. The aim of this work was evaluate osteogenic and antibacterial effects E. hydromethanolic extracts.Dried aerial components were extracted using a mixture methanol:water (1:1), for 26 days, yielding three extracts that tested (10-1000 μg/ml) in human osteoblastic cells: E1, E2 EM (a E1 E2, 1:1). Cell cultures, performed on cell culture plates or over hydroxyapatite (HA) substrates, assessed markers. In addition, the...
Silk fibroin has been widely explored for many biomedical applications, due to its biocompatibility and biodegradability. The aim of this work was study the role dialysis freezing on structural conformation, thermal properties morphology silk hydrogels. Hydrogels were prepared after 3 7 days effect analyzed. For that purpose, a part hydrogels underwent at -20 °C 24 h, followed by lyophilization rest kept 8 with further lyophilization. characterized X-ray diffraction (XRD), Fourier...