A5019522829- Forensic Toxicology and Drug Analysis
- Psychedelics and Drug Studies
- Analytical chemistry methods development
- Poisoning and overdose treatments
- Paraquat toxicity studies and treatments
- Cannabis and Cannabinoid Research
- Biochemical Analysis and Sensing Techniques
- Neurotransmitter Receptor Influence on Behavior
- Metabolomics and Mass Spectrometry Studies
- Sexual Differentiation and Disorders
- Protein Interaction Studies and Fluorescence Analysis
- Hormonal and reproductive studies
- Pesticide Residue Analysis and Safety
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Advanced Chemical Sensor Technologies
- Trauma and Emergency Care Studies
- Mass Spectrometry Techniques and Applications
- Pesticide Exposure and Toxicity
- Alcohol Consumption and Health Effects
- Autoimmune Bullous Skin Diseases
- Animal Ecology and Behavior Studies
- Healthcare during COVID-19 Pandemic
- Phytochemistry Medicinal Plant Applications
- Medicinal Plants and Neuroprotection
- Antibiotics Pharmacokinetics and Efficacy
Universidade Estadual de Campinas (UNICAMP)
2013-2024
Universidade Feevale
2024
Abstract Synthetic cathinones continue to proliferate in clandestine drug markets worldwide. N ‐ethylnorpentylone (also known as ‐ethylpentylone or ephylone) is a popular emergent cathinone, yet little information available about its toxicology and pharmacology. Here we characterize the analytical quantification, clinical presentation, pharmacological mechanism of action for ‐ethylnorpentylone. Liquid chromatography coupled tandem mass spectrometry (LC–MS/MS) was used quantify blood obtained...
The ritualistic use of ayahuasca is becoming a global phenomenon. This beverage contains combination monoamine oxidase inhibitors (harmine, harmaline, and tetrahydroharmine) N,N-dimethyltryptamine, the main substance responsible for its visionary effect. recreational similar alkaloids N,N-dimethyltryptamine has increased in recent years, mainly because their hallucinogenic effects. In present study, concentrations psychoactive three powder samples seized by São Paulo State Police nine...
The aim of this work was to develop a simple and fast method for the detection paraquat in oral fluid, plasma, urine by capillary electrophoresis with diode-array (CE-DAD), diagnose acute poisoning related herbicide. use fluid analytical toxicology has been established drugs abuse, but not diagnosis pesticides poisoning. Oral collected without stimulation using absorbent cotton swabs. Sample preparation included diluting, vortex mixing, centrifuging biological ethyl as internal standard....
Abstract In this work, two methods were developed to determine herbicides paraquat, glyphosate, and aminomethylphosphonic acid ( AMPA ) in marijuana samples by capillary electrophoresis. For paraquat analysis, sample was extracted with aqueous acetic solution analyzed zone electrophoresis direct UV detection. The running electrolyte 50 mmol/L phosphate buffer (p H 2.50). glyphosate , indirect / VIS detection used, as these substances do not present chromophoric groups. Samples 5 hydrochloric...
Abstract The content of ecstasy tablets has been changing over the years, and nowadays 3,4‐methylenedioxymethamphetamine ( MDMA ) is not always present in tablets. aim this study was to investigate chemical composition seized labeled as ecstasy. We analyzed samples from 150 different seizures made by Sao Paulo's State Police gas chromatography–mass spectrometry. 44.7% samples, another twenty active substances were identified these tablets, such caffeine, 2C‐B, piperazines, amphetamines,...
Objective. To describe a prospective case series of poisonings caused by ingestion illegal rodenticides containing acetylcholinesterase inhibitors, mainly "chumbinho," followed-up the Campinas PCC for period 1 year. Case series. Seventy-six cases were included, which 53.9% males. Age ranged from 2 to 74 years (median = 36 years). The main circumstances leading poisoning intentional (suicide attempts 92.1%; homicide 5.3%), and 65.8% admitted less than hours after ingestion. Most patients...
IDENTIFYING MARIJUANA CANNABINOIDS (Cannabis sativa L.).Marijuana L.) is the most cultivated, trafficked and consumed illicit drug worldwide.Estimates indicate 10% of individuals experiencing marijuana become daily users, 20-30% use it weekly.Around 489 natural compounds have been identified in this plant, which 70 are cannabinoids, responsible for psychic effects.The relevant cannabinoid Δ9-THC, recognized as main chemical substance with psychoactive aims work was to investigate whether...
The present work describes a practical application of Green Analytical Toxicology (GAT) during the development an eco-friendly dispersive liquid-liquid microextraction (DLLME) avoiding use highly toxic chlorinated solvents that are commonly used in this type technique. purpose was to further consolidate GAT guidelines method development. Thus, full optimization using multivariate statistical approach and validation were performed. To end, synthetic cathinones (SCs), one major classes new...
CHEMICAL IDENTIFICATION OF CHLOROPHENYLPIPERAZINE IN SEIZED TABLETS.Designer drug is a term used to describe psychoactive drugs of abuse which are usually synthesized by modifying the molecular structures existing abuse.The gained widespread popularity when MDMA (ecstasy) experienced boom in mid 1980´s.In Brazil, designer seizures have increased last few years, and actually tablets with unknown compounds began be forwarded Forensic Laboratories.This work describes analytical assays that were...
CONTEXT: Most patients with methanol poisoning typically show up one to several days after ingestion, presenting severe acidosis, visual disorders, or both. Reports of hospitalization less than 6 h exposure are unusual. We describe a case attempted suicide using admitted 3 ingestion. CASE REPORT: A 52-year-old male was hospitalized intentional ingestion 150 ml 99.9% no co-ingestion ethanol. He alert and cooperative, nausea vertigo, reporting six episodes vomiting. Physical examination showed...
Ayahuasca is a beverage obtained from decoctions of the liana Banisteriopsis caapi plus shrub Psychotria viridis. This contains combination monoamine oxidase inhibitors (harmine, harmaline, and tetrahydroharmine) N,N-dimethyltryptamine, main substance responsible for its visionary effect. The ritualistic use ayahuasca becoming global phenomenon. Most members churches consume this throughout their life, many reports have discussed therapeutic potential beverage. consumed orally, liver, as...
To report a near-fatal poisoning after intentional injection of ricin from castor bean (Ricinus communis) extract.A 21 year-old man self-injected ∼3 mL extract intramuscularly and subcutaneously in the left antecubital fossa. Upon admission to our ED (1 h post-exposure; day 1, D1) he was awake alert, but complained mild local pain showed slight edema erythema. He evolved refractory shock (∼24 post-exposure) that required administration large volume fluids high doses norepinephrine...
Ayahuasca is a beverage used in religious rituals of indigenous and nonindigenous groups, its therapeutic potential has been investigated. obtained by decoction the Banisteriopsis caapi that contains β‐carbolines (harmine, harmaline, tetrahydroharmine) plus Psychotria viridis N , ‐dimethyltryptamine. Although plants folk medicine are recognized as safe, many them have genotoxic potential. The Salmonella/microsome assay usually first line mutagenicity evaluation products intended for use. Our...
Steroid measurement is a challenge in pediatric endocrinology. Currently, liquid chromatography with tandem mass spectrometry (LC-MS/MS) considered gold standard for this purpose. The aim of study was to compare both LC-MS/MS and immunoassay (IA) androgens before after human recombinant chorionic gonadotropin (rhCG) stimulus children 46,XY disorders sex development (DSD).Nineteen patients DSD were evaluated; all them prepubertal non-gonadectomized. Testosterone, dihydrotestosterone (DHT),...
Ayahuasca is a beverage obtained from Banisteriopsis caapi plus Psychotria viridis. B. contains the β-carbolines harmine, harmaline, and tetrahydroharmine that are monoamine oxidase inhibitors P. viridis N,N-dimethyltryptamine (DMT) responsible for visionary effects of beverage. use becoming global phenomenon, recreational DMT similar alkaloids has also increased in recent years; such uncontrolled can lead to severe intoxications. In this investigation, liquid chromatography-tandem mass...
Abstract Considering that the use of psychoactive substances (PSs) is a risk factor to either higher intensity or frequency suicidal behavior, hair analysis was conducted investigate most consumed PSs (opiates, amphetamine stimulants, marijuana, cocaine and heroin) in patients who attempted suicide received urgent care at emergency service. Hair samples were extracted using methanol sonicated under heating then analyzed liquid chromatography-tandem mass spectrometry. During validation,...