A5088157350- Chronic Kidney Disease and Diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Dialysis and Renal Disease Management
- Advanced Glycation End Products research
- Cardiovascular Health and Disease Prevention
- Diabetes Treatment and Management
- Natural Antidiabetic Agents Studies
- Antimicrobial Peptides and Activities
- Renal Diseases and Glomerulopathies
- Heme Oxygenase-1 and Carbon Monoxide
- Metabolism, Diabetes, and Cancer
- Eosinophilic Esophagitis
- Asthma and respiratory diseases
- Aldose Reductase and Taurine
- Blood Pressure and Hypertension Studies
- Digital Games and Media
- Educational Games and Gamification
- Parasites and Host Interactions
- Central Venous Catheters and Hemodialysis
- Sirtuins and Resveratrol in Medicine
- Retinal Imaging and Analysis
- Neurological Disorders and Treatments
- Ion channel regulation and function
- Mobile and Web Applications
- Vascular Procedures and Complications
Universidade Estadual de Campinas (UNICAMP)
2014-2024
Iscte – Instituto Universitário de Lisboa
2023
Hospital de Clínicas da Unicamp
2022
Universidade Federal de Minas Gerais
2000-2003
Abstract Prior research has shown that in experimental diabetes mellitus, green tea reduces albuminuria by decreasing podocyte apoptosis through activation of the WNT pathway. We investigated effect polyphenols (GTP) on residual diabetic subjects with nephropathy. conducted a randomised, double-blind study 42 urinary albumin-creatinine ratio (UACR) >30 mg/g, despite administration maximum recommended dose renin-angiotensin (RAS) inhibition. Patients were randomly assigned to two equal...
Background Sodium-glucose cotransporter 2 (SGLT2) inhibitors attenuate incident cardiovascular outcomes, irrespective of baseline GFR, in conservatively managed CKD. As this condition inexorably progresses to demanding KRT, drug withdrawal is supported by the current lack evidence safety SGLT2 dialysis. Methods This study was a prospective, single-center, open-label trial (ClinicalTrials.gov identifier: NCT05343078) aimed at assessing pharmacokinetic properties and dapagliflozin patients...
Reduction in sirtuin 1 (Sirt-1) is associated with extracellular matrix (ECM) accumulation the diabetic kidney. Theobromine may reduce kidney ECM rats. In current study, we aimed to unravel, under conditions, mechanism of induced by a reduction Sirt-1 and effect theobromine these events. vitro, used immortalized human mesangial cells (iHMCs) exposed high glucose (HG; 30 mM), or without small interfering RNA for NOX4 Sirt-1. vivo, spontaneously hypertensive rats (SHR) were rendered means...
Introduction: Arteriovenous fistula (AVF) is the preferred vascular access for hemodialysis. Whether acute arm movement impacts arteriovenous blood flow unknown. Methods: In this cross-sectional analysis, we evaluated AVF using an ultrasound device at resting and after three muscle movements proximal (elbow flexion, shoulder adduction abduction) or distal (fist extension fingers squeeze), without with a 2 kg load. Results: We included 23 patients (14 men), 53 ± 13 years, 26.1% diabetes, on...
The prevalence of allergic diseases such as asthma has increased markedly over the past few decades. To evaluate possible mutual influence helminth infection and allergy, combined effects experimental airway inflammation with Strongyloides venezuelensis on various parasitological inflammatory indices were evaluated in rat. A challenge immunized rats aerosolized ovalbumin (OVA) resulted eosinophilic that peaked 48 h after was accompanied by hyperresponsiveness (AHR) to an intravenous...
Metformin, an AMP-activated protein kinase (AMPK) activator, has been shown in previous studies to reduce kidney fibrosis different models of experimental chronic disease (CKD). However, all these studies, the administration metformin was initiated before establishment renal disease, which is a condition that does not typically occur clinical settings. The aim present study investigate whether could arrest progression established well-recognized model CKD, subtotal nephrectomy (Nx) model....
Abstract A dramatic blood neutrophilia is an important feature of the severe envenoming caused by Brazilian scorpion Tityus serrulatus and may contribute to development lung injury in children. We examined effects intravenous injection T. venom (TsV) on total number leukocytes neutrophils anesthetized rats. Injection TsV (250 μg/kg) induces a significant leukocytosis 2 3 h after its injection, explained increase neutrophils. The release catecholamines action adrenoceptors responsible for...
Optimal control of traditional risk factors only partially attenuates the exceeding cardiovascular mortality individuals with diabetes. Employment machine learning (ML) techniques aimed at identification novel features prediction is a compelling target to tackle residual risk. The objective this study identify clinical phenotypes T2D which are more prone developing disease.The Brazilian Diabetes Study single-center, ongoing, prospective registry individuals. Eligible patients 30 years old or...
Nowadays, people are more predisposed to being self-taught due the availability of online information. With digitalization, information appears not only in its conventional state, as blogs, articles, newspapers, or e-books, but also interactive and enticing ways. Video games have become a transmission vehicle for knowledge, they require specific treatment respect their presentation way which users interact with them. This includes usability guidelines heuristics that provide video game...
Abstract The accumulation of advanced glycation end-products (AGEs) elicits morphofunctional kidney impairment. AGEs levels can be noninvasively estimated by skin autofluorescence (SAF). We explored whether high SAF predicts outcomes in type 2 diabetes (T2D) individuals. study was conducted as a predefined analysis the Brazilian Diabetes Study, prospective single-center cohort T2D adults. Data from 155 individuals followed for up to 1716 days were considered. incidence major adverse events...
Resumo O acúmulo de produtos finais glicação avançada (AGEs, do inglês advanced glycation end-products) provoca comprometimento morfofuncional dos rins. Os níveis AGEs podem ser estimados forma não invasiva por autofluorescência da pele (sAF). Exploramos se a sAF elevada prediz desfechos renais em indivíduos com diabetes tipo 2 (DT2). estudo foi realizado como uma análise predefinida Estudo Brasileiro sobre Diabetes, coorte prospectiva centro único adultos DT2. Foram considerados os dados...
Abstract Background. Optimal control of traditional risk factors only partially attenuates the exceeding cardiovascular mortality individuals with diabetes. Employment machine learning (ML) techniques aimed at identification novel features prediction is a compelling target to tackle residual risk. Objective. To identify clinical phenotypes T2D which are more prone for developing disease. Methods. The Brazilian Diabetes Study single-center, ongoing, prospective registry individuals. Eligible...