A5027775147- Adenosine and Purinergic Signaling
- Organ Transplantation Techniques and Outcomes
- Connexins and lens biology
- Liver physiology and pathology
- Xenotransplantation and immune response
- Pharmacological Effects of Natural Compounds
- S100 Proteins and Annexins
- Pharmacological Receptor Mechanisms and Effects
- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Synthesis and Biological Evaluation
- Education during COVID-19 pandemic
- COVID-19 Clinical Research Studies
- Ion channel regulation and function
- Cancer Treatment and Pharmacology
- Nicotinic Acetylcholine Receptors Study
- Bipolar Disorder and Treatment
- Healthcare and Venom Research
- Wnt/β-catenin signaling in development and cancer
- Phytochemistry and Biological Activities
- Vitamin C and Antioxidants Research
- Natural product bioactivities and synthesis
- Science and Education Research
Universidade Federal do Rio de Janeiro
2014-2024
Fundação Oswaldo Cruz
2006-2017
Faculdades Oswaldo Cruz
2017
Previous investigations have provided evidence that the N-terminal peptide of annexin 1 (peptide Ac2-26) has capacity reproducing anti-inflammatory actions full-length protein in many systems. In current study, we report effectiveness Ac2-26 as an antiallergic tool a model rat pleurisy and provide indication for some mechanisms involved. rats inflamed by injection ovalbumin into pleural cavity 14 days postsensitization, (50–200 μg/cavity) inhibited mast cell degranulation, plasma leakage,...
ATP physiologically activates the P2X7 receptor (P2X7R), a member of P2X ionotropic family. When activated by high concentrations (i.e., at inflammation sites), this is capable forming pore that allows molecules up to 900 Da pass through. This upregulated in several diseases, particularly leukemia, rheumatoid arthritis and Alzheimer's disease. A selective antagonist could be useful treatment P2X7R activation-related diseases. In present study, we have evaluated parameters using vitro...
Abstract Background We investigated the effects of signaling molecules, cyclic AMP (cAMP) and protein-kinase C (PKC), on gap junctional intercellular communication (GJIC) between thymic epithelial cells (TEC). Results Treatment with 8-Br-cAMP, a cAMP analog; or forskolin, which stimulates production, resulted in an increase dye transfer adjacent TEC, inducing three-fold enhancement mean fluorescence coupled cells, ascertained by flow cytometry after calcein transfer. These treatments also...
Gap junctions are intercellular channels that allow the communication of neighboring cells. This depends on contribution a hemichannel by each cell to form gap junction. In mammalian cells, is formed six connexins, monomers with four transmembrane domains and C N terminal within cytoplasm. permit exchange ions, second messengers, small metabolites. addition, they have important roles in many forms cellular physiological processes such as synaptic transmission, heart contraction, growth...
Abstract Objectives This work investigated the acute antinociceptive effect of a synthetic chalcone, 4-dimethylamino chalcone (DMAC), as well its effects on vincristine-induced peripheral neuropathy (VIPN) in mice. Methods The inhibitory activity myeloperoxidase was assessed by measuring HOCl formation. Formalin and hot plate tests were used to study DMAC. VIPN induced through administration vincristine sulphate (0.1 mg/kg, i.p., 14 days). Then, DMSO, DMAC (10 or 30 mg/kg; i.p.), pregabalin...
Acute liver failure (ALF) has a poor prognosis and, despite intensive care support, reported average survival is only 10–40%. The most common causes responsible for ALF are viral hepatitis (mainly A and B) acetaminophen poisoning. Hepatic transplantation the appropriate treatment patients with unlikely supportive alone. Survival rates after can be as high 80–90% at end of first year. However, there shortage donors not uncommon that no donor matches patient in time to avoid death. Therefore,...
Gap junctions are intercellular channels that allow the communication of neighboring cells. This depends on contribution a hemichannel by each cell to form gap junction. In mammalian cells, is formed six connexins, monomers with four transmembrane domains and C N terminal within cytoplasm. permit exchange ions, second messengers, small metabolites. addition, they have important roles in many forms cellular physiological processes such as synaptic transmission, heart contraction, growth...
This study evaluated the analgesic and anti-inflammatory activities of Vitex polygama. Ethyl acetate butanol fractions (10-30 mg/kg), obtained from hydroalcoholic leaf extract, showed an antinociceptive effect in acetic acid-induced abdominal writhing test, formalin test modified hot plate mice, indicating a peripheral action. were effective inhibiting nitric oxide TNF-α production, respectively, RAW 264.7 macrophages. Both mg/kg) acute mice with vincristine-induced neuropathic pain exposed...