A5026566675- Pharmacological Effects of Natural Compounds
- Phytochemistry and Biological Activities
- Phytochemistry and Bioactive Compounds
- Natural product bioactivities and synthesis
Universidade Federal do Rio de Janeiro
2020-2022
Tuberculosis (TB) remains a worldwide public health threat because of the emergence resistant strains and subsequent inappropriate response to current therapy. We have been studying restinga plants' antimycobacterial anti-inflammatory potential. Dichloromethane fraction (DCM) from Vitex polygama Cham. showed high activity against Mycobacterium tuberculosis (Mtb) H37Rv. In this context, DCM isolated compounds were investigated Mtb H37Rv M299 (MDR strain) for their immunomodulatory...
This study evaluated the analgesic and anti-inflammatory activities of Vitex polygama. Ethyl acetate butanol fractions (10-30 mg/kg), obtained from hydroalcoholic leaf extract, showed an antinociceptive effect in acetic acid-induced abdominal writhing test, formalin test modified hot plate mice, indicating a peripheral action. were effective inhibiting nitric oxide TNF-α production, respectively, RAW 264.7 macrophages. Both mg/kg) acute mice with vincristine-induced neuropathic pain exposed...