A5072390710- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Phytochemical compounds biological activities
- Phytochemistry Medicinal Plant Applications
- Essential Oils and Antimicrobial Activity
- Phytochemistry and Bioactivity Studies
- Traditional and Medicinal Uses of Annonaceae
- Microbial Natural Products and Biosynthesis
- Biochemical and Structural Characterization
- Fungal Biology and Applications
- Natural product bioactivities and synthesis
- Cancer therapeutics and mechanisms
- Quinazolinone synthesis and applications
- Bioactive Compounds and Antitumor Agents
- Antimicrobial Peptides and Activities
- Synthesis and biological activity
- Piperaceae Chemical and Biological Studies
- Infectious Diseases and Mycology
- Coccidia and coccidiosis research
- Transgenic Plants and Applications
- Immune cells in cancer
- Endodontics and Root Canal Treatments
- Genomics, phytochemicals, and oxidative stress
- Phytochemistry and Bioactive Compounds
- Multicomponent Synthesis of Heterocycles
State University of Norte Fluminense
2015-2024
Amazon (United States)
2024
Universidade Federal do Rio de Janeiro
2021-2022
Tuberculosis (TB) remains a serious public health problem aggravated by the emergence of M. tuberculosis (Mtb) strains resistant to multiple drugs (MDR). Delay in TB treatment, common MDR-TB cases, can lead deleterious life-threatening inflammation susceptible hyper-reactive individuals, encouraging discovery new anti-Mtb and use adjunctive therapy based on anti-inflammatory interventions. In this study, series forty synthetic chalcones was evaluated vitro for their antimycobacterial...
Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (Mtb) that in most cases induces irreversible necrosis of lung tissue as result excessive inflammatory reactions. The murine model TB resistant C57BL/6 mice infected with reference Mtb strains widely used studies; however, these do not show necrotic pathology, which restricts their use studies damage. Recently, we demonstrated lesions could be induced the highly virulent belonging to modern Beijing...
The chemical study of roots from Azadirachta indica A. Juss., Meliaceae, led to the isolation two new terpenoids, limonoid morenolide and diterpene 17-hydroxy-sandaracopimar-8,15-dien-11-one, in addition four well-known limonoids nimbinene, nimbinal, nimbandiol salannin, three diterpenoids nimbidiol, ferruginol, 6,7-dehydroferruginol. Their structural elucidations were based on one bidimensional Nuclear Magnetic Resonance Electrospray ionization mass spectrometry spectra data which was...
The genus Ocotea (Lauraceae) is distributed mainly in tropical and subtropical regions. Some species of this as O. puberula quixos have been described the literature, showing antibacterial activity. And macrophylla showed anti-inflammatory activity with inhibition COX-1, COX-2, LOX-5. purpose study was phytochemical investigation plant notata from Restinga Jurubatiba National Park, Macaé, RJ, Brazil, search for antimycobacterial fractions compounds. crude extract evaluated presented<mml:math...
A phytochemical study of leaves and twigs Psychotria nuda resulted in 19 compounds, including five indole alkaloids, N,N,N-trimethyltryptamine, lyaloside, strictosamide, strictosidine, 5α-carboxystrictosidine; two flavonolignans, cinchonain Ia Ib; an iridoid, roseoside; a sugar, lawsofructose; coumarin, scopoletin; diterpene, phytol; three triterpenes, pomolic acid, spinosic rotungenic acid; steroids, sitosterol, stigmasterol, campesterol, β-sitosterol-3-O-β-d-glucoside,...
L. is widely distributed in tropical regions and the ethnobotanical uses of this species encompass medicinal applications for treatment respiratory, antimicrobial, gynecological diseases. Chemical studies reveal a diverse array secondary metabolites, including terpenes, flavonoids, prenylated compounds. Extracts from
Abstract Ocotea notata (Lauraceae) is popularly known as white-cinnamon. species have several medicinal uses, especially for treating chest pain, rheumatism and wounds. The present study aimed to analyze the chemical composition of O. n-hexane fraction, in addition its anti-mycobacterial immunomodulatory activities. fraction was analyzed by GC-MS chromatographed afford 15 subfractions (SF1-15), where SF5 identified, NMR, sesquiterpene spathulenol. most potent inhibiting nitric oxide (NO)...
Increased prevalence of high virulent strains Mycobacterium tuberculosis and M. kansasii require the development new antimycobacterial drugs safe more effective. And, in this context, endophytic fungi have been known as prominent sources bioactive compounds. To study anti-inflammatory activities six fungal metabolites: austdiol (1), diacetate (2), mycoleptone A (3) eugenitin (4) isolated from cultures endophyte Mycoleptodiscus indicus; emodin (5) Penicillium citrinum δ-lactam (6) soil...
The phytochemistry of the species Cedrela fissilis Vell., family Meliaceae, also popularly known as "cedro rosa", was investigated, leading to isolation four compounds from crude methanolic extract its seeds; triterpene Piscidinol A (1), and three limonoids, Andirolide N (2), Mexicanolide (3), Proceranolide (4).Subsequently, antimycobacterial, anti-inflammatory, cytotoxicity activities these were investigated.The limonoid (4) presented best result for investigated biological activities, with...
6 μg/mL.O que sugere estas substâncias apresentam concentrações não interferiramm na atividade mitocondrial das células de macrófagos RAW 264.7.Ainda, Frações em acetato etila do caule Dalbergia Monetaria se mostraram com melhor inibitória sobre a produção NO representadas por 6,682±1,14%.Conclusão: Com esses resultados é possível identificar um potencial antinflamatório presente nessas espécies, ausência toxicidade nas concnetrações testadas.Havendo necessidade novos testes para ampliação...
Os autores externos submeteram sua publicação para apresentação de trabalho no evento “International Symposium on Immunobiologicals”, que foi coordenado e organizado pelo Instituto Tecnologia em Imunobiológicos (Bio-Manguinhos), da Fundação Oswaldo Cruz. Apresentador do material: Vinicius Oliveira Mussi. Tipo material apresentado: Pôster.
Among non-tuberculous mycobacteria, Mycobacterium kansasii is one of the most pathogenic, able to cause pulmonary disease indistinguishable from tuberculosis in immunocompetent susceptible adults. The lack animal models that reproduce human-like lung disease, associated with necrotic pathology, impairs studies M. virulence and pathogenicity. In this study, we examined ability C57BL/6 mice, intratracheally infected highly virulent strains, produce a chronic infection pathology. As first...
In Brazil, the Eugenia genus is traditionally used to treat several types of human diseases, including diabetes, gastric ulcers and rheumatoid arthritis. Previous studies demonstrated that medicinal properties astringens Cambess (Myrtaceae), popularly known as “baguaçu" in were associated with anti-inflammatory antimicrobial activities exhibited by plant extracts. Anti-tubercular effects E. have not been elucidated yet. To study anti-tubercular immunomodulatory potential leaves extracts...
A new triterpene, named milemaronol (1), was isolated from Homalolepis suffruticosa Engl., Simaroubaceae, along with 10 known metabolites, chaparrinone (2), scopoletin (3), 5-methoxycanthin-6-one (4), eurylene (5), hispidol (6), B (7), nilocitine (8), α-dihydronylocytine (9), β-dihydronylocytine (10), and teurilene (11). These compounds were characterized based on their spectral data, mainly 1D ( 1 H, 13 C-APT) 2D H- H-COSY, NOESY, HSQC, HMBC) NMR mass spectra (HR-ESI-MS), in comparison data...
This study aimed to evaluate endophytic fungi isolated from Tocoyena bullata and Humiria balsamifera plant species for their antimycobacterial anti-inflammatory activities, focusing on severe pulmonary tuberculosis cases which are often associated with exacerbated inflammation.Mycobacterium suspensions were incubated the samples 5 days. RAW 264.7 macrophages stimulated LPS also them 24 h assess inhibition of inflammatory mediator production cytotoxicity. C57BL/6 mice infected Mtb M299...
Os autores externos submeteram sua publicação para apresentação de trabalho no evento “International Symposium on Immunobiologicals”, que foi coordenado e organizado pelo Instituto Tecnologia em Imunobiológicos (Bio-Manguinhos), da Fundação Oswaldo Cruz. Apresentador do material: Sanderson Dias Calixto. Tipo material apresentado: Pôster.