A5047858425- Traditional and Medicinal Uses of Annonaceae
- Alkaloids: synthesis and pharmacology
- Natural product bioactivities and synthesis
- Biological Activity of Diterpenoids and Biflavonoids
- Phytochemistry and Biological Activities
- Phytochemistry Medicinal Plant Applications
- Mosquito-borne diseases and control
- Chemical synthesis and alkaloids
- Plant biochemistry and biosynthesis
- Berberine and alkaloids research
- Bioactive Natural Diterpenoids Research
- Phytochemicals and Antioxidant Activities
- Natural Antidiabetic Agents Studies
- Medicinal plant effects and applications
- Essential Oils and Antimicrobial Activity
- Malaria Research and Control
- Piperaceae Chemical and Biological Studies
- Botanical Research and Applications
- Advances in Cucurbitaceae Research
- HIV Research and Treatment
- Ethnobotanical and Medicinal Plants Studies
- Analytical Chemistry and Chromatography
- Environmental and biological studies
- Sphingolipid Metabolism and Signaling
- Tannin, Tannase and Anticancer Activities
Universidade Federal do Rio de Janeiro
2013-2024
Centro de Tecnologia Mineral
2015
Virginia Tech
1993-1997
This work reports the nutritional potential and antiradical activity of cladodes Brazilian Opuntia monacantha Haw. (Cactaceae), as well isolation kaempferol isorhamnetin through activity-guided fractionation from its active MeOH extract. TLC, HPLC-DAD NMR techniques were used to detect identify compounds. The water (91.1%), ash, protein, fibre lipid contents (15.0, 5.4, 18.5 1.4 g/100 g, respectively) shown be quite similar mean values other spp., some widely food forage. antioxidant their...
Uncaria tomentosa (Willd.) DC (Rubiaceae) is a species native to the Amazon rainforest and surrounding tropical areas that endowed with immunomodulatory properties widely used around world. In this study we investigated potential of (UT) aqueous-ethanol extract on progression immune-mediated diabetes.C57BL/6 male mice were injected MLDS (40 mg/kg) orally treated UT at 10-400mg/kg during 21 days. Control groups received alone or respective dilution vehicle. Pancreatic mononuclear infiltrate...
Leaves of Eugenia florida DC. have been used in folk medicine as hypotensive, hypoglycemic, antipyretic and for gastrointestinal disorders, among others.In this study dried leaves were extracted with ethanol the extract was partitioned hexane, CHCl 3 , EtOAc, BuOH water to afford triterpenoid-and polyphenol-rich fractions which analyzed by GC-MS UFLC-DAD-ESI-Ion Trap-MS n .All tested against proliferation leukemic K562 human melanoma SK-Mel-28 cell lines their ability scavenge DPPH...
Dengue is the major Arbovirus in world, annually causing morbidity and death. Severe dengue associated with changes endothelial barrier function due to production of inflammatory mediators by immune cells endothelium. virus (DENV) replicates efficiently human vitro elicits responses resulting permeability. Uncaria tomentosa (Willd.) DC.(Rubiaceae), known as cat's claw, has been used folk medicine for treatment a wide-array symptoms, several scientific studies reported its antiviral,...
Uncaria tomentosa (Willd.) DC. and U. guianensis (Aubl.) Gmel., known as cat's claw, are large woody vines native to the Amazonian Central American rainforests. The species contain, in different proportions, indole oxindole alkaloids, triterpenoid glycosides, sterols proanthocyanidins. can be chemically identified by its alkaloid profile content, whereas has no satisfactorily established chemical markers. This work describes, for first time, isolation of kaempferol-3,7-O-(α)-dirhamnoside...
Uncaria tomentosa (Willd.) DC (Rubiaceae) is a large woody vine that native to the Amazon and Central American rainforests used widely in traditional medicine for its immunomodulatory antiinflammatory activities. The present work vivo immunotoxic vitro experiments investigate effects of pentacyclic oxindole alkaloid extract from U. bark on lymphocyte phenotype, Th1/Th2 cytokine production, cellular proliferation cytotoxicity. For immunotoxicity testing, BALB/c male mice were treated once day...
Dengue fever may present hemorrhages and cavitary effusions as result of exacerbated immune responses. We investigated hydro-alcoholic extracts from leaves (UGL) bark (UGB) the medicinal species Uncaria guinanensis with respect to antiviral effects in virus (DENV) infection immunological parameters associated vivo physiopathological features.Chemical profiles UGB or UGL were compared thin layer chromatography 1H nuclear magnetic resonance using flavonoid compounds a pentacyclic oxindole...
Uncaria tomentosa (UT) is a medicinal plant popularly known as cat’s claw belonging to the Rubiaceae family that has been reported display antiviral and anti-inflammatory activities. The chikungunya virus (CHIKV) outbreaks constitute Brazilian public health concern. CHIKV infection develops an abrupt onset of fever, usually accompanied by skin rash, besides incapacitating polyarthralgia. There no vaccine available or treatment for infection. present study evaluates hydroalcoholic extract UT...
Uncaria tomentosa (Willd.) DC. and guianensis (Aubl.) Gmel., commercially known as cat's claw, are large woody vines native of the Amazon Central America rainforests. These Rubiaceae species face nowadays an imminent risk extinction due to indiscriminate harvesting in wild well increasing deforestation their natural habitat. This work describes vitro cultivation methods for both with determination, by HPLC, pentacyclic oxindole alkaloid contents profiles plant material. The results have...
The methanol (MeOH) leaf extracts of the species Faramea bahiensis, F. hyacinthina and truncata (Rubiaceae) have previously shown in vitro non-cytotoxic anti-dengue virus serotype 2 (DENV2) activities human hepatocarcinoma cell lineage (HepG2). Chemical studies led to isolation major flavonoids, but quite complex fractions phenolic compounds still remain.To complete study leaves access presence these stems spp. by online high-performance liquid chromatography-diode array...
This study assessed the extraction efficiency of ursolic (UA) and oleanolic acids (OA), as well total phenols in aqueous hydroethanolic extracts dry apple peels at room temperature.AFTER RUNNING PRELIMINARY ASSAYS ON DECOCTIONS AND TINCTURES (ETHANOL: water 7:3 v/v), from dried (cv. Fuji) were obtained by static maceration over varied intervals (2 to 180 days). The UA OA content was quantified High Performance Liquid Chromatography with Diode Array Detection (HPLC-DAD) a reversed phase...
The defatted fractions of the Faramea hyacinthina and F. truncata (Rubiaceae) leaf MeOH extracts showed in vitro non-cytotoxic anti-dengue virus serotype 2 (DENV2) activity human hepatocarcinoma cell lineage (HepG2). Submitting these to developed RP-SPE method allowed isolating antiviral flavanone (2S)-isosakuranetin-7-O-β-d-apiofuranosyl-(1→6)-β-d-glucopyranoside (1) from both species yielded less active sub-fractions. new diastereoisomeric epimer pair (2S) + (2R)...
CUCURBITACINS AND THEIR MAIN STRUCTURAL CHARACTERISTICS.The cucurbitacins are highly oxygenated triterpenoid compounds found in several botanical families that show high toxicity and varied biological activities.This review presents the main so far isolated their key structural characteristics.It complements updates existing reviews on this subject.
O gênero Uncaria (Rubiaceae) é representado na América do Sul e Central por duas espécies: U. tomentosa (Willd.) DC. guianensis (Aubl.) Gmel., conhecidas popularmente como unha-de-gato. Ambas são trepadeiras perenes, sendo empregadas prevenção cura de várias doenças. Nessas plantas encontrados alcalóides oxindólicos indólicos, triterpenos glicosilados, taninos flavonóides. Seis pentacíclicos, considerados seus marcadores: especiofilina, mitrafilina, uncarina F, isomitrafilina, pteropodina...
As espécies Uncaria tomentosa (Willd.) DC. e U. guianensis (Aubl.) Gmel. da família botânica Rubiaceae, conhecidas no Brasil como unha-de-gato, são trepadeiras lenhosas de ocorrência na floresta Amazônica outras áreas tropicais América do Sul Central. Elas têm sido usadas medicina tradicional diversas tribos indígenas por pelo menos dois mil anos para processos degenerativos inflamatórios, úlceras gástricas, contracepção entre outros. Suas propriedades terapêuticas, a complexidade...
The leaves of Bauhinia forficata L. (Fabaceae) are used in Brazilian folk medicine mainly as antidiabetic agent. They rich polyphenols, and kaempferitrin other flavonoids currently considered basic chemical criteria for the quality effectiveness extracts phytopharmaceuticals derived from them. Aiming to expand scope current data profile B. subsp. forficata, present study employed HPLC-DAD HPLC-DAD-ESI/MS compare flavonoid content specimens collected seasonally during one year, two different...
AMAZONIAN Bauhinia purpurea (Fabaceae). Plants of the species (Fabaceae) are used in treatment several infections and diseases, especially diabetes.In this paper, with an aim to contribute knowledge chemistry therapeutic potential Amazonian genus Bauhinia, flavonoid profiles leaves branches collected Manaus São Gabriel da Cachoeira/AM were analyzed by HPLC-DAD ESIMS.Differences detected along presence rutin isoquercitrin Manaus.All samples showed antioxidant activity, however, no cytotoxic...