A5014041655- Metabolomics and Mass Spectrometry Studies
- Environmental Toxicology and Ecotoxicology
- Pesticide and Herbicide Environmental Studies
- Gut microbiota and health
- Proteoglycans and glycosaminoglycans research
- Carbohydrate Chemistry and Synthesis
- Diet and metabolism studies
- Gastrointestinal motility and disorders
- Analytical Chemistry and Chromatography
- Physiological and biochemical adaptations
- Legume Nitrogen Fixing Symbiosis
- Aquatic Ecosystems and Phytoplankton Dynamics
- Platelet Disorders and Treatments
- Ion Transport and Channel Regulation
- Nanocomposite Films for Food Packaging
- Drug Transport and Resistance Mechanisms
- Amino Acid Enzymes and Metabolism
- Glycosylation and Glycoproteins Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Advanced NMR Techniques and Applications
University of California, Riverside
2013-2019
Earthworm metabolism is recognized as a useful tool for monitoring environmental insults and measuring ecotoxicity, yet extensive earthworm metabolic profiling using 1H nuclear magnetic resonance (NMR) spectroscopy has been limited in scope. This study aims to expand the embedded material coelomic fluid, coelomocytes, tissue aid systems toxicology research. Fifty-nine metabolites within Eisenia fetida were identified, with 47 detected 41 54 whole-worm samples extracts. The newly but known...
Earthworms ( Eisenia fetida) are vital members of the soil environment. Because their sensitivity to many contaminants, monitoring earthworm metabolism may be a useful indicator environmental stressors. Here, metabolic profiles exposure five chloroacetanilide herbicides and one enantiomer (acetochlor, alachlor, butachlor, racemic metolachlor, S-metolachlor, propachlor) observed in coelomic fluid using proton nuclear magnetic resonance spectroscopy (NMR) gas chromatography-mass spectrometry...
The capacity of the colon to absorb microbially produced amino acids (AAs) and underlying mechanisms AA transport are incompletely defined. We measured profile 16 fecal AAs along rat ceco-colonic axis compared unidirectional absorptive fluxes across mucosal tissues isolated from jejunum, cecum, proximal using an Ussing chamber approach, in conjunction with 1 H-NMR ultra-performance liquid chromatography-mass spectrometry chemical analyses. Passage stool cecum midcolon was associated...
The anticoagulant properties of heparin stem in part from high-affinity binding to antithrombin-III (AT-III) inducing a 300-fold increase its inhibitory activity against the coagulation protease factor Xa. minimal structural requirements for AT-III are contained rare pentasaccharide sequence containing 3,6-O-sulfated N-sulfoglucosamine residue. ACE is used this work measure relative affinities low molecular weight heparins (LWMHs) dalteparin, enoxaparin, and tinzaparin synthetic drug...
The large intestine (cecum and colon) is a complex biochemical factory of vital importance to human health. It plays major role in digestion absorption by salvaging nutrients from polysaccharides via fermentation initiated the bacteria that comprise gut microbiome. We hypothesize intestinal epithelium absorbs limited number luminal metabolites with bioactive potential while actively excluding those toxic effects. To explore this concept, we combined 1H NMR detection Ussing chamber...