A5086463465- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Adenosine and Purinergic Signaling
- S100 Proteins and Annexins
- RNA modifications and cancer
- Metabolism, Diabetes, and Cancer
- Pancreatitis Pathology and Treatment
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Circular RNAs in diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Cells and Metastasis
- Advanced Glycation End Products research
- Angiogenesis and VEGF in Cancer
- Autophagy in Disease and Therapy
- Molecular Communication and Nanonetworks
- 3D Printing in Biomedical Research
- Galectins and Cancer Biology
- Immune Response and Inflammation
- Renal Diseases and Glomerulopathies
- Colorectal Cancer Treatments and Studies
- Cancer-related Molecular Pathways
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Heat shock proteins research
Jilin University
2012-2024
Union Hospital
2024
The University of Texas Health Science Center at Houston
2021-2022
Union Hospital
2014-2022
City Of Hope National Medical Center
2012-2013
Central South University
2013
Third Xiangya Hospital
2013
City of Hope
2012-2013
Shandong University
2013
Beckman Research Institute
2013
Interaction of RAGE (the receptor for advanced glycation endproducts) with its ligands can promote tumor progression, invasion, and angiogenesis. Although blocking signaling has been proposed as a potential anticancer strategy, functional contributions expression in the microenvironment (TME) have not investigated detail. Here, we evaluated effect genetic depletion TME on growth gliomas. In both invasive noninvasive glioma models, animal survival was prolonged knockout (Ager(-/-)) mice....
Abstract Purpose: S100B is member of a multigenic family Ca2+-binding proteins, which overexpressed by gliomas. Recently, we showed that low concentrations attenuated microglia activation through the induction Stat3. We hypothesized overexpression in gliomas could promote tumor growth modulating activity tumor-associated macrophages (TAM). Experimental Design: stably transfected GL261 glioma cell lines with constructs (S100Bhigh) or underexpressed (S100Blow) and compared their...
5-Fluorouracil (5-Fu) is a widely applied anti-cancer agent against colorectal cancer (CRC), yet number of CRC patients have developed resistance to 5-Fu-based chemotherapy. The epidermal growth factor receptor (EGFR) recognized as an oncogene that promotes diverse progresses. In addition, long noncoding RNAs (lncRNAs) are essential regulators cancers. Here we report EGFR and lncRNA-FGD5-AS1 promoted 5-Fu CRC. By establishing the 5-Fu-resistant cell line, detected EGFR, FGD5-AS1, glucose...
Recently, we showed that intratumoral delivery of low-dose, immunostimulatory CpG oligodeoxynucleotides conjugated with carbon nanotubes (CNT-CpG) was more effective than free and not only eradicated intracranial (i.c.) gliomas but also induced antitumor immunity protected mice from subsequent i.c. or systemic tumor rechallenge. Here, examined whether the same "intracerebral immunotherapy" strategy could be applied to treatment metastatic brain tumors.Mice both s.c. melanomas were injected...
Even when treated with aggressive current therapies, most patients glioblastoma survive less than two years. Rapid tumor growth, an invasive nature, and the blood-brain barrier, which limits penetration of large molecules into brain, all contribute to poor response associated conventional therapies. Immunotherapy has emerged as a therapeutic approach that may overcome these challenges. We recently reported single-walled carbon nanotubes (SWCNTs) can be used dramatically increase...
MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression through the endogenous RNA interference machinery. Treatments with combination of chemotherapy surgery essential for advanced-stage colorectal cancer. However, development chemoresistance is a major obstacle clinical application anticancer drugs. In this study, we report miR-203-SIK2 axis involves in regulation Taxol sensitivity colon cancer cells. MiR-203 downregulated human tumor specimens and cell lines compared...
Gastric cancer (GC) is a commonly occurring human malignancy. The 5-fluorouracil (5-Fu) first-line anti-gastric agent. However, large number of GC patients developed 5-Fu resistance. Currently, the roles and molecular mechanisms lncRNA-SNHG16-modulated resistance in gastric remain elusive.Expressions lncRNA, miRNA, mRNA were detected by qRT-PCR Western blot. RNA-RNA interaction was examined RNA pull-down luciferase assay. Cell viability apoptosis rate under treatments determined MTT assay...
Radiotherapy (RT) is commonly used to treat multi-tumors attenuate the risk of recurrence. Despite impressive initial clinical responses, a large proportion patients experience resistance RT. Therefore, identification functionally relevant biomarkers would be beneficial for radioresistant patients. Adenosine monophosphate-activated kinase (AMPK) recognized as mediator tumor suppressor gene function. In present study, radio-sensitive and -resistant colon cancer patient samples were compared...
Gastric cancer (GC) is one of the most malignancies leading to human mortality due its development, progress, metastasis and poor prognosis, despite development remarkable chemotherapy surgery. The 5-fluorouracil (5-Fu) an effective anti-gastric agent. However, a fraction GC patients acquire 5-Fu chemoresistance.In this study, CagA protein was detected from CagA-positive gastric by qRT-PCR immunohistochemistry. resistant cell line generated MKN45-CagA cells which transfected with...
Pancreatitis is currently the leading cause of gastrointestinal hospitalizations in US. This condition occurs response to abdominal injury, gallstones, chronic alcohol consumption or, less frequently, remains idiopathic. CD73 a cell surface ecto-5'-nucleotidase that generates extracellular adenosine, which can contribute resolution inflammation by binding adenosine receptors on infiltrating immune cells. We hypothesized genetic deletion would result more severe pancreatitis due decreased...
Autophagy is a common phenomenon in cancer metabolism. However the mechanism and guiding significance of autophagy development gastric has remained to be elucidated. In present study, 75 tissue specimens were collected at The China Japan Union Hospital Jilin University (Changchun, China). Of these samples, 16 cases stage 1, 40 2 19 3. Polymerase chain reaction western blotting used detect messenger RNA protein expression Beclin-1, significant associated with cellular autophagy. It was found...
ErbB2 is known to upregulate glycolysis in breast cancer, however, the precise mechanisms remain unclear. In present study, upregulated Hexokinase II (HK II) activity by increasing binding of HK mitochondrial outer membrane. Dysregulated glucose metabolism high ErbB2‑expressing cancer cells induces susceptibility starvation and inhibition. Additionally, has a tendency dissociate from mitochondria membrane ErbB2‑overexpressing following treatment with inhibitor, 3‑BrPA. Furthermore, 3-BrPA...
ABSTRACT Background and Aims Pancreatitis is currently the leading cause of gastrointestinal hospitalizations in US. This condition occurs response to abdominal injury, gallstones, chronic alcohol consumption or, less frequently, remains idiopathic. CD73 a cell surface ecto-5’-nucleotidase that generates extracellular adenosine, which can contribute resolution inflammation by binding adenosine receptors on infiltrating immune cells. We hypothesized genetic deletion would result more severe...
Objective To study the clinical effect of tacrolimus combined with small dose prednisolone in treatment IgA nephropathy. Methods 84 cases nephropathy were randomly divided into group and control accordance digital table method.The was given simple hormone treatment, while treated prednisolone.The efficacy safety compared between two groups. Results The effective rate (100.00%) complete remission (73.81%) significantly higher than those (76.19%, 23.81%), differences statistically...
Abstract Gastric cancer (GC) is one of the most human malignancies. The 5-fluorouracil (5-Fu) a first-line anti-gastric chemotherapeutic agent. However, large number GC patients developed 5-Fu resistance. Currently, biological roles and molecular mechanisms lncRNA-SNHG16 in resistant gastric still remain elusive. Here we report SNHG16 as well PTBP1 are positively associated with resistance cancer. significantly upregulated tumors cell lines. Silencing or effectively sensitized cells to 5-Fu....