A5024888976- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cardiac Structural Anomalies and Repair
- Epigenetics and DNA Methylation
- Cardiomyopathy and Myosin Studies
- Cardiac Valve Diseases and Treatments
- Trauma Management and Diagnosis
- Vitamin C and Antioxidants Research
- Congenital heart defects research
- Advanced Glycation End Products research
- Mitochondrial Function and Pathology
- Galectins and Cancer Biology
- Trace Elements in Health
- Aortic Disease and Treatment Approaches
- Pericarditis and Cardiac Tamponade
- Syphilis Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Pharmacological Effects of Natural Compounds
- Morinda citrifolia extract uses
- Metabolomics and Mass Spectrometry Studies
- Pain Mechanisms and Treatments
- Metabolism, Diabetes, and Cancer
- Alzheimer's disease research and treatments
- Atherosclerosis and Cardiovascular Diseases
Union Hospital
2014-2024
Jilin University
2014-2024
Union Hospital
2017-2022
Health Commission of Jilin Province
2022
Weatherford College
2020
MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression through the endogenous RNA interference machinery. Treatments with combination of chemotherapy surgery essential for advanced-stage colorectal cancer. However, development chemoresistance is a major obstacle clinical application anticancer drugs. In this study, we report miR-203-SIK2 axis involves in regulation Taxol sensitivity colon cancer cells. MiR-203 downregulated human tumor specimens and cell lines compared...
A previous study suggested that activin inhibited myocardial cell apoptosis. This thus aimed to explore the effects of A-follistatin system on apoptosis in heart failure (HF) rats order determine whether or not mechanism operates through endoplasmic reticulum stress (ERS) pathway. Myocardial infarction (MI) by vascular deprivation was used induce HF. The enzyme-linked immunosorbent assay detect A, follistatin and brain natriuretic peptide (BNP) contents serum. Immunohistochemical staining...
Glycyrrhizin has a role in immune regulation the central nervous system, but its impact on sciatic nerve injury had not previously been reported. In this study, BALB/c mouse model of was used to explore glycyrrhizin repair and underlying mechanism. with intragastric gavage 10 20 mg/kg weight per day (mid‑ high‑dose, respectively) inhibited p75 neurotrophin receptor (p75NTR) expression at protein mRNA levels versus 5 (low‑dose) group control (0.9% NaCl solution) one, two, four eight weeks...
Abstract Rationale: In recent decades, the incidence of advanced syphilis has declined due to early recognition and application effective antibiotics. Advanced often manifests in cardiovascular system as simple aortitis, aortic valve insufficiency, coronary artery stenosis or obstruction, Aortic aneurysm mucinous myocarditis. most case reports on subject, acute myocardial infarction caused by was reported be insufficiency a result involvement aorta. Patient concerns: The patient 48-year-old...
Background Vitamins A, D (Vitamin D2 and vitamin D3) E, play an important role during pregnancy. Methods Sera were collected from 1056 normal pregnant women, who between 18 40 years old, at seven different hospitals in northeastern China. The levels of Vitamin A E the sera samples detected using HPLC (High Performance Liquid Chromatography), level was measured by LC ‐ MS (Liquid Chromatography‐Mass Spectrometry). Data analyzed IBM SPSS Statistics 21. Results mean 0.39 mg/L (0.38‐0.39), 20.44...
Abstract Background Atherosclerosis is the most frequent pathological process that causes cardiovascular diseases. Objective The present study aimed to confirm miRNAs associated with atherosclerosis and explore molecular mechanism of miR‐34c its target high mobility group box protein 1 (HMGB1) in control growth smooth muscle cells development atherosclerosis. Methods Real‐time PCR was firstly performed miRNA correlation atherosclerosis, computational analysis luciferase assay were miR‐34c,...
Our study's goal was to find out acute myocardial infarction (AMI) patients' NUMB gene expression patterns and evaluate its role as a diagnostic marker for AMI detection.Peripheral blood drawn from 124 individuals who had an 115 patients stable coronary artery disease (SCAD). The real-time quantitative polymerase chain reaction used measure the mRNA level of in peripheral blood.The group's 0.906 (0.181-0.954), whereas SCAD 1.024 (0.207-1.127). However, group 0.885 times lower than (P <...
Abstract Background Free wall rupture is a rare complication of myocardial infarction, occurring as early few hours after infarction. It usually happens transmural infarction and has very high mortality rate. The diagnosis free requires echocardiographic evidence pericardial leakage or tamponade. patient's cause death often attributed to other causes such cardiac arrhythmia unless determined by open heart surgery autopsy. Diagnostic tools for post-infarction are limited date. Case...
Abstract Rationale: Hypertrophic cardiomyopathy (HCM) is an inherited myocardial disease and a common cause of sudden cardiac death, heart failure, atrial fibrillation stroke. In families affected by HCM, genotyping useful for identifying susceptible relatives. the present study, we investigated disease-causing mutations in three-generation Chinese family with HCM using whole exome sequencing (WES). Patient concerns: The proband, 50-year-old man, was diagnosed at age 41 years. He presented...