A5101548801- Fungal Biology and Applications
- RNA modifications and cancer
- Soybean genetics and cultivation
- Urban Heat Island Mitigation
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Allergic Rhinitis and Sensitization
- Plant Micronutrient Interactions and Effects
- Cholesterol and Lipid Metabolism
- Diet and metabolism studies
- Risk and Safety Analysis
- Sperm and Testicular Function
- Soil Carbon and Nitrogen Dynamics
- Plant nutrient uptake and metabolism
- Lipoproteins and Cardiovascular Health
- Air Quality and Health Impacts
- Hematopoietic Stem Cell Transplantation
- Metabolomics and Mass Spectrometry Studies
- Asthma and respiratory diseases
- Receptor Mechanisms and Signaling
- Occupational Health and Safety Research
- Heavy metals in environment
- Tea Polyphenols and Effects
- Advanced biosensing and bioanalysis techniques
- Diabetes, Cardiovascular Risks, and Lipoproteins
Second Affiliated Hospital of Fujian Medical University
2025
Fujian Medical University
2025
Liaoning University
2025
Jilin University
2007-2024
Huadong Hospital
2010-2024
China Pharmaceutical University
2023-2024
Chinese Academy of Civil Aviation Science and Technology
2015-2024
Union Hospital
2021-2024
Fudan University
2010-2024
Union Hospital
2022-2024
Spermatozoa undergo a poorly understood activation process induced by bicarbonate and mediated cyclic adenosine 3',5'-monophosphate (cAMP). It has been assumed that mediates its effects through changes in intracellular pH or membrane potential; however, we demonstrate here directly stimulates mammalian soluble adenylyl cyclase (sAC) activity vivo vitro pH-independent manner. sAC is most similar to cyclases from cyanobacteria, regulation of conserved these early forms life. also expressed...
Intracellular targets of the ubiquitous second messenger cAMP are located at great distances from most widely studied source cAMP, G protein responsive transmembrane adenylyl cyclases. We previously identified an alternative in mammalian cells lacking spanning domains, "soluble" cyclase (sAC). now demonstrate that sAC is distributed specific subcellular compartments: mitochondria, centrioles, mitotic spindles, mid-bodies, and nuclei, all which contain targets. Distribution these...
Modulation of environmental pH is critical for the function many biological systems. However, molecular identity sensor and its interaction with downstream effector proteins remain poorly understood. Using male reproductive tract as a model system in which luminal acidification sperm maturation storage, we now report novel pathway regulation linking bicarbonate activated soluble adenylyl cyclase (sAC) to vacuolar H+ATPase (V-ATPase). Clear cells epididymis vas deferens contain abundant...
Potassium is an important nutrient element requiring high concentration for photosynthetic metabolism. The potassium deficiency in soil could inhibit soybean (Glycine max (L.) Merr.) photosynthesis and result yield reduction. Research on the variations of different tolerant soyben varieties should provide information breeding program. Two representative Tiefeng 40 (tolerance to K+ deficiency) GD8521 (sensitive were hydroponically grown measure photosynthesis, chlorophyll fluorescence...
Purpose The purpose of this paper is to make a comprehensive analysis 354 publications about Pythagorean fuzzy sets (PFSs) from 2013 2020 in order comprehensively understand their historical progress and current situation, as well future development trend. Design/methodology/approach First, describes the fundamental information these on PFSs, including data information, annual trend prediction basic features. Second, most productive influential authors, countries/regions, institutions cited...
The RNA-binding protein DiGeorge Critical Region 8 (DGCR8) and its partner nuclease Drosha are essential for processing of microRNA (miRNA) primary transcripts (pri-miRNAs) in animals. Previous work showed that DGCR8 forms a highly stable active complex with ferric [Fe(III)] heme using two endogenous cysteines as axial ligands. Here we report reduction the iron to ferrous [Fe(II)] state abolishes pri-miRNA activity. causes dramatic increase rate dissociation from DGCR8, rendering labile....
The impairment of amyloid-β (Aβ) clearance in the brain plays a causative role Alzheimer's disease (AD). Polarity distribution aquaporin-4 (AQP4) is important to remove Aβ from brain. AQP4 polarity can be influenced by ratio two isoforms M1 and M23 (AQP4-M1/M23), however, it unknown whether AQP4-M1/M23 changes AD. Histone deacetylase 3 has been reported significantly increased AD Moreover, evidence indicated that microRNA-130a (miR-130a) possibly mediates regulation histone on repressing...
Serum is required for the survival and growth of most animal cells. In serum-free medium, B lymphoblastoid cells fibroblasts die after 2 days. We report that submicromolar concentrations Δ9-tetrahydrocannabinol (THC), Δ8-THC, cannabinol, or cannabidiol, but not WIN 55,212-2, prevented serum-deprived cell death. Δ9-THC also synergized with platelet-derived factor in activating resting NIH 3T3 fibroblasts. The cannabinoids' supportive effect did correlate their ability to bind known...
Alzheimer's disease is an irreversible, progressive neurodegenerative disorder. The accumulation of Aβ in the brain thought to play a causative role development cognitive dysfunction disease. p75 neurotrophin receptor great importance protect against burden and its expression regulated by histone acetylation. This study investigated whether phytochemical sulforaphane, pan-histone deacetylase inhibitor, up-regulates via affecting acetylation protection We found that sulforaphane ameliorated...
Background . The aim of this study is to investigate whether (-)-epigallocatechin-3-gallate (EGCG) can prevent the UA-induced inflammatory effect human umbilical vein endothelial cells (HUVEC) and involved mechanisms in vitro. Methods HUVEC were subjected uric acid (UA) with or without EGCG treatment. RT-PCR western blots performed determine level inflammation marker. antioxidant activity was evaluated by measuring scavenged reactive oxygen species (ROS). Functional studies role Notch-1...
(1) Background: Obesity and diabetes continue to reach epidemic levels in the population with major health impacts that include a significantly increased risk of coronary atherosclerosis. The imbalance trace elements body caused by nutritional factors can lead progression (2) Methods: We measured concentrations sodium (Na), potassium (K), magnesium (Mg), calcium (Ca), Zinc (Zn), iron (Fe) peripheral blood samples from 4243 patients performed baseline analysis propensity matching patient...
Peracetic acid (PAA) oxidation, which is a kind of chemical method for sludge pretreatment, has been verified to be valid promoting anaerobic digestion performance. However, the methane production still limited at certain levels by this method, because excess PAA negative effects on methanogens. This work selected freezing combined with form composite pretreatment technology synergistically improving biomethane production. According experimental data, yield was largely enhanced from 166.4 ±...
DiGeorge critical region 8 (DGCR8) is essential for maturation of microRNAs (miRNAs) in animals. In the cleavage primary transcripts miRNAs (pri-miRNAs) by Drosha nuclease, DGCR8 protein directly binds and recognizes pri-miRNAs through a mechanism currently controversial. Our previous data suggest that trimerizes upon cooperative binding to pri-mir-30a. However, separate study proposed model which molecule contacts one or two pri-miRNA molecules using its double-stranded RNA domains. Here,...
All known heme-thiolate proteins ligate the heme iron using one cysteine side chain. We previously found that DiGeorge Critical Region 8 (DGCR8), an essential microRNA processing factor, associates with of unknown redox state when overexpressed in Escherichia coli. On basis similarity 450-nm Soret absorption peak DGCR8-heme complex to cytochrome P450 containing ferrous CO bound, we identified 352 as a probable axial ligand DGCR8. Here further characterize interaction biochemical and...