A5063088149- Animal Virus Infections Studies
- Parathyroid Disorders and Treatments
- Aquaculture disease management and microbiota
- Virus-based gene therapy research
- Alzheimer's disease research and treatments
- Viral gastroenteritis research and epidemiology
- Pharmacological Effects and Toxicity Studies
- Homelessness and Social Issues
- Paraquat toxicity studies and treatments
- Genomics, phytochemicals, and oxidative stress
- Ion Channels and Receptors
- Medical Imaging and Pathology Studies
- Circular RNAs in diseases
- Virology and Viral Diseases
- Epigenetics and DNA Methylation
- Garlic and Onion Studies
- Plant responses to water stress
- Food Allergy and Anaphylaxis Research
- Neurogenesis and neuroplasticity mechanisms
- interferon and immune responses
- MicroRNA in disease regulation
- Insect and Pesticide Research
- Ion Transport and Channel Regulation
- Solar-Powered Water Purification Methods
- Chronic Kidney Disease and Diabetes
Suizhou Central Hospital
2021-2024
Sun Yat-sen University
2019-2024
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
2023-2024
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2023-2024
Wuhan University of Technology
2023
North Sichuan Medical University
2018-2020
Nanchong Central Hospital
2020
Jinzhou Medical University
2017-2020
China Medical University
2017-2019
China-Japan Friendship Hospital
2019
The impairment of amyloid-β (Aβ) clearance in the brain plays a causative role Alzheimer's disease (AD). Polarity distribution aquaporin-4 (AQP4) is important to remove Aβ from brain. AQP4 polarity can be influenced by ratio two isoforms M1 and M23 (AQP4-M1/M23), however, it unknown whether AQP4-M1/M23 changes AD. Histone deacetylase 3 has been reported significantly increased AD Moreover, evidence indicated that microRNA-130a (miR-130a) possibly mediates regulation histone on repressing...
Abstract Iridoviruses are nucleocytoplasmic large dsDNA viruses that infect invertebrates and ectothermic vertebrates. The hypermethylated genome of vertebrate iridoviruses is unique among animal viruses. However, the map function iridovirus genomic methylation remain unknown. Herein, methylated Infectious spleen kidney necrosis virus (ISKNV, a fish iridovirus), its role in viral infection, investigated. level ISKNV 23.44%. essential for amplification, but there no correlation between...
Alzheimer's disease is an irreversible, progressive neurodegenerative disorder. The accumulation of Aβ in the brain thought to play a causative role development cognitive dysfunction disease. p75 neurotrophin receptor great importance protect against burden and its expression regulated by histone acetylation. This study investigated whether phytochemical sulforaphane, pan-histone deacetylase inhibitor, up-regulates via affecting acetylation protection We found that sulforaphane ameliorated...
Viral diseases are a significant risk to the aquaculture industry. Transient receptor potential vanilloid 4 (TRPV4) has been reported be involved in regulating viral activity mammals, but its regulatory effect on viruses teleost fish remains unknown. Here, role of TRPV4-DEAD box RNA helicase 1 (DDX1) axis infection was investigated mandarin (Siniperca chuatsi). Our results showed that TRPV4 activation mediates Ca2+ influx and facilitates infectious spleen kidney necrosis virus (ISKNV)...
Tyrosine kinase receptor A (TrkA) plays an important role in the protection of cholinergic neurons Alzheimer’s disease (AD). This study was designed to investigate whether β-hydroxybutyrate (BHB), endogenous histone deacetylase (HDAC) inhibitor, upregulates expression TrkA by affecting acetylation SH-SY5Y cells treated with amyloid β-protein (Aβ). The results showed that BHB ameliorated reduction cell vitality and downregulation induced Aβ. Furthermore, inhibited upregulation HDAC1/2/3...
Global aquaculture production yielded a record of 122.9 million tons in 2022. However, ~10% farmed aquatic animal is lost each year due to various infectious diseases, resulting substantial economic waste. Therefore, the development vaccines important for prevention and control diseases. Gene-deletion live attenuated are efficacious because they mimic natural pathogen infection generate strong antibody response, thus showing good potential administration via immersion. most gene-deletion...
Objectives: Paraquat (PQ) poisoning can induce mitophagy and pulmonary fibrosis. Cyclosporine A (CsA) is an inhibitor of mitophagy. This study aimed at investigating whether CsA could inhibit PQ-induced fibrosis in rats.Materials Methods: Male Sprague–Dawley (SD) rats were treated with vehicle saline (control), 50 mg/kg PQ by gavage alone, or together different doses CsA. At 14 days post-induction, the levels PTEN-induced putative kinase 1 (PINK1) Parkin expression individual mitochondrial...
Secondary hyperparathyroidism (SHPT) is common in dialysis patients with end-stage renal disease (ESRD). Parathyroidectomy (PTX) an effective treatment for SHPT. Postoperative severe hypocalcemia (SH) a and complication after PTX. This study aimed to investigate the potential predictive markers of SH ESRD SHPT near-total PTX (near-tPTX) without autotransplantation (AT).A retrospective analysis involving 131 who were treated near-tPTX AT between January August 2018 was performed. Demographic...
Chronic Kidney Disease - Mineral and Bone Disorder (CKD-MBD) is a significant cause of morbidity among haemodialysis patients associated with pathological changes in phosphate, calcium parathyroid hormone (PTH). In the ACTIVE Dialysis study, extended hours dialysis reduced serum phosphate but did not important PTH or calcium. This secondary analysis aimed to determine if therapies may have influenced these findings identify differences between patient subgroups.The study randomised 200...
Yellowfin seabream (Acanthopagrus latus) is one of the most commercially important marine fish in China. In this study, a new continuous cell line, named ALS cells, was developed from spleen tissue A. latus. The line maintained Dulbecco's modified Eagle medium/Nutrient Mixture F-12 Ham (DMEM/F-12) supplemented with 10% fetal bovine serum (FBS) and successfully cultured up to 50 passages. authenticated by amplifying sequencing mitochondrial cytochrome C oxidase subunit-I (coi-I) gene. had...
Infectious spleen and kidney necrosis virus (ISKNV) poses a significant threat to aquaculture sustainability, particularly affecting mandarin fish (
Paraquat (PQ) poisoning can cause oxidative stress, acute lung injury (ALI), and fibrosis. Excess stress induce mitophagy. However, whether PQ exposure mitophagy, contributing to the development of ALI pulmonary fibrosis in vivo has not been clarified. Here, we show that induces fiber accumulation rats a time-dependent manner, accompanied by upregulating fibronectin (FN) Collagen I (COL-I) expression. increased mitophagosome formation PINK1 Parkin expression lungs rats. Similarly, reduced...
Objective To compare the effects of 3 enrichment models cancer stem cells (CSCs) in colon DLD-1 cells. Methods DLD-1 were cultured kinds serum-free medium containing various growth factors to generate spheroid cells, including G1 group using 10 ng/mL EGF+ bFGF, G2 20 bFGF and G3 bFGF. The cell proportion CD133+ CD44+ , ALDH+ confirmed by flow cytometery. mRNA expression related genes (Oct4, Sox2, Nanog) CSCs (CD133, CD44, CD166, ALDH, CD66c) detected real-time polymerase chain...
Diabetic kidney disease (DKD) is a serious complication of diabetes mellitus, and common cause end-stage renal (ESRD). The clinical diagnosis DKD usually depends on the history diabetes, characteristics urinary albumin, presence or absence retinopathy, active urine sediment, etc. However, more studies have suggested high misdiagnosis rate this method. This paper reviewed progress diagnosis. Key words: Diabetes mellitus; Diabetic disease; Non-diabetic disease; Diagnosis