In clinical cohort studies, high expression of long-chain acyl-coenzyme A synthetases 1 (ACSL1 gene) in peripheral white blood cells patients with acute myocardial infarction (AMI) has been utilized as molecular markers diagnosis.The plasma triglyceride level AMI is significantly higher than that healthy individuals.We hypothesized the ACSL1 increases triglyceride, which one pathogenesis promoted by ACSL1.In this report, cell culture based methods were adopted to test hypothesis and further...

(1) Background: Obesity and diabetes continue to reach epidemic levels in the population with major health impacts that include a significantly increased risk of coronary atherosclerosis. The imbalance trace elements body caused by nutritional factors can lead progression (2) Methods: We measured concentrations sodium (Na), potassium (K), magnesium (Mg), calcium (Ca), Zinc (Zn), iron (Fe) peripheral blood samples from 4243 patients performed baseline analysis propensity matching patient...

Background Heart failure is a complex end stage of various cardiovascular diseases with poor prognosis, and the mechanisms for development progression heart have always been hot point. However, molecular underlying post transcriptional regulation not fully elucidated. Current data suggest that microRNAs (miRNAs) are involved in pathogenesis could serve as new biomarker, but precise regulatory still unclear. Methods The differential miRNA profile rat model post-infarction was determined using...

Objective . To find molecular markers for the diagnosis of acute myocardial infarction (AMI), this research further verified relationship between expression level FFAR2 gene and AMI by expanding sample size based on previous chip results. Methods Peripheral venous leukocytes were collected from 113 patients with 94 noncoronary artery disease as experimental group control group, respectively. Real-time fluorescence quantitative polymerase chain reaction was used to detect gene. Western blot...

The current study aimed to investigate whether the increased expression of long chain acyl‑coenzymeA synthetase 1 (ACSL1) in peripheral blood leukocytes (PBL) may be a molecular marker for genetic evaluation acute myocardial infarction (AMI). mechanism action ACSL1 pathogenesis AMI was also investigated. A total 75 patients with and 70 individuals without coronary heart disease were selected participate present study. demographic clinical information enrolled subjects recorded. Reverse...

This study aimed to use gene chips investigate differential expression profiles in the occurrence and development of acute myocardial infarction (AMI). The included 12 AMI patients healthy individuals. Total mRNA peripheral bloodwas extracted reversed-transcribed cDNA for microarray analysis. After establishing two pools with three subjects each (3 3 individuals), remaining samples were used RT-qPCR confirm data. From results, seven genes randomly selected RT-qPCR. results analyzed by 2-ΔΔCt...

Objective: Coronary heart disease (CHD) is a complex caused by multifaceted interaction between genetic and environmental factors, which makes identification of the most likely candidate proteins their associated risk markers big challenge. Atherosclerosis presented broad spectrum diseases, including stable coronary artery (SCAD) acute myocardial infarction (AMI), progressive stage SCAD. As such, correct prompt diagnosis atherosclerosis turns into imperative for precise diagnosis, treatment...

Pneumatosis of the portal vein is considered a rare imaging sign rather than disease. It usually occurs in patients with digestive tract diseases such as intestinal obstructive diseases, mesenteric vascular closed abdominal trauma, and liver transplantation. Because its high mortality rate, it also termed “sign death.” Hawthorn contains tannic acid, seafood rich calcium, iron, carbon, iodine, other minerals proteins. Thus, consuming both hawthorn together can result formation an indigestible...

Aims: The present study was designed to evaluate whether the expression of suppressor cytokine signaling 3 (SOCS3) gene could serve as a biomarker predict risk acute myocardial infarction (AMI). Basic Methods: Peripheral white blood cells were collected from 113 patients with AMI and 92 stable coronary artery disease (SCAD). SOCS3 mRNA levels in peripheral determined by real-time quantitative polymerase chain reaction, protein Western blotting. Results: 1.33-fold higher than that SCAD...

Background The transmembrane protein Notch1 is associated with cell growth, development, differentiation, proliferation, apoptosis, adhesion, and the epithelial mesenchymal transition. Proteomics, as a research method, uses series of sequencing techniques to study composition, expression levels, modifications proteins. Here, association between acute myocardial infarction (AMI) was investigated using proteomics, assess possibility biomarker for disease. Methods Fifty-five eligible patients...

This study presented the new Life's Essential 8 (LE8) framework for examining cardiovascular health (CVH) to analyze potential relationship between latter and hyperuricemia (HUA) in U.S. population.

Abstract Atherosclerosis refers to a disease characterized by the formation of lipid plaque deposits within arterial walls, leading reduced blood flow or blockage outflow. The process endothelial injury induced oxidized low‐density lipoprotein (ox‐LDL) is considered initial stage atherosclerosis. Ferroptosis form iron‐dependent, non‐apoptotic cell death, and current research suggests its association with coronary artery (CAD). In this study, we observed correlation between expression SREBP‐1...

Background: Thrombospondin (THBS) 3 is an adhesive glycoprotein involved in cell-cell and cell-matrix interactions. The purpose of this study to determine whether THBS3 expression peripheral blood can be used as a biomarker predict the risk acute myocardial infarction (AMI). Methods: 111 patients with stable coronary artery disease (SCAD) 112 AMI was obtained. experimental control cohorts were SCAD groups, respectively. mRNA protein both groups determined using reverse-transcription...

Abstract Rationale: In recent decades, the incidence of advanced syphilis has declined due to early recognition and application effective antibiotics. Advanced often manifests in cardiovascular system as simple aortitis, aortic valve insufficiency, coronary artery stenosis or obstruction, Aortic aneurysm mucinous myocarditis. most case reports on subject, acute myocardial infarction caused by was reported be insufficiency a result involvement aorta. Patient concerns: The patient 48-year-old...

Objective This study aimed to investigate whether differential expression of the retinoic acid receptor-related orphan receptor A ( RORA) gene is related occurrence acute myocardial infarction (AMI). Methods was a retrospective study. White blood cells 93 patients with and 74 stable coronary artery disease were collected. Reverse transcription quantitative polymerase chain reaction western blotting used measure RORA mRNA protein expression, respectively. Results levels in peripheral...

Abstract Background: The G0/G1 switch 2 (G0S2) gene is closely related to lipolysis, cell proliferation, apoptosis, oxidative phosphorylation, and the development of a variety tumors. aim present study was expand sample size confirm relationship between expression G0S2 in peripheral blood acute myocardial infarction (AMI) based on previous chip results. Methods: Three hundred patients were initially selected, which 133 excluded accordance with exclusion criteria. Peripheral leukocytes...

This study aimed to determine the amount of expression ATP-binding cassette subfamily B member 1 (ABCB1) gene chip as a prospective diagnostic marker for acute myocardial infarction (AMI) in wide population . In AMI and control groups, 113 patients with 83 persons non-coronary artery disease were selected peripheral venous leukocyte collection. Western blot real-time polymerase chain reaction (RT-PCR) employed detect relative ABCB1 both groups. The results showed that transcription protein...

Previous microarray analysis on peripheral blood leukocytes from three patients with acute myocardial infarction (AMI) showed that elevated expression of membrane bound o-acyltransferase domain containing 7(

ZCCHC9 is a zinc finger protein with CCHC structure and has important roles in several cellular processes. This study was conducted on an expanded number of samples to evaluate The usefulness gene expression peripheral blood as molecular marker for the prediction AMI (acute myocardial infarction) risk.Peripheral were collected from 117 patients stable CAD (coronary atherosclerotic disease) 126 AMI. mRNA level assessed by qRT-PCR, its determined Western blotting.The group exhibited reduced...

Our study's goal was to find out acute myocardial infarction (AMI) patients' NUMB gene expression patterns and evaluate its role as a diagnostic marker for AMI detection.Peripheral blood drawn from 124 individuals who had an 115 patients stable coronary artery disease (SCAD). The real-time quantitative polymerase chain reaction used measure the mRNA level of in peripheral blood.The group's 0.906 (0.181-0.954), whereas SCAD 1.024 (0.207-1.127). However, group 0.885 times lower than (P <...