A5101690785- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Genomics and Phylogenetic Studies
- Advanced Image Processing Techniques
- Plant Gene Expression Analysis
- Optical measurement and interference techniques
- Liver physiology and pathology
- Plant biochemistry and biosynthesis
- Sperm and Testicular Function
- Aortic aneurysm repair treatments
- RNA Research and Splicing
- Dietary Effects on Health
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Mesenchymal stem cell research
- Cancer, Stress, Anesthesia, and Immune Response
- Chromosomal and Genetic Variations
- Image Processing Techniques and Applications
- Connective tissue disorders research
- Molecular Biology Techniques and Applications
- Advanced Vision and Imaging
- Extracellular vesicles in disease
- Bioactive Compounds and Antitumor Agents
- Amoebic Infections and Treatments
- PI3K/AKT/mTOR signaling in cancer
Henan University of Science and Technology
2022-2025
Southwest Minzu University
2023-2025
Chinese Academy of Sciences
2016-2024
Kunming Institute of Botany
2019-2024
Ministry of Natural Resources
2024
Shaanxi Provincial Land Engineering Construction Group
2024
Second Affiliated Hospital of Zhejiang University
2024
Early Warning (United States)
2024
Xinjiang Medical University
2022-2023
Capital Medical University
2017-2022
Objective Effects of the diet-induced gut microbiota dysbiosis reach far beyond gut. We aim to uncover direct evidence involving gut–testis axis in aetiology impaired spermatogenesis. Design An excessive-energy metabolic syndrome (MetS) sheep model was established. The testicular samples, host metabolomes and microbiome were analysed. Faecal transplantation (FMT) confirmed linkage between Results demonstrated that number arrested spermatogonia markedly elevated by using 10× single-cell...
Abstract Paclitaxel (PTX) is widely used in the front-line chemotherapy for gastric cancer (GC), but resistance limits its use. Due to lack of proper models, mechanisms underlying PTX GC were not well studied. Using established PTX-resistant cell sublines HGC-27R, we first time integrated biological traits and molecular GC. Data revealed that cells characterized by microtubular disorders, an EMT phenotype, reduced responses antimitotic drugs, apoptosis (marked upregulated β-tubulin III,...
This study prepared palm stearin/linseed oil-based margarines (PST/LO-BMs) and oil oleogel-based (PST/LO-OBM) by incorporating varying proportions (20–60% phase) of linseed (LO) LO-based oleogel, respectively. By comparing PST/LO-OBMs PST/LO-BMs, it was found that the introduction phytosterol–γ-oryzanol (PO) complexes glycerol monostearate (GMS) to PST/LO-OBM induced three distinct crystalline morphologies: needle-like crystals, spherical cluster-type crystals. These crystal assemblies...
Recently, deep-learning-based super-resolution methods have achieved excellent performances, but mainly focus on training a single generalized deep network by feeding numerous samples. Yet intuitively, each image has its specific representation, and is expected to acquire an adaptive model. For this issue, we propose novel convolution modulation (CoMo) mechanism build image-specific networks, exploiting the principal information of feature generate weight, thereby adaptively modulating...
Cellulases, hemicellulases, and pectinases play important roles in fruit development maturation. Although mutants with defects these processes have not been reported for cellulase or hemicellulase genes, the ARABIDOPSIS DEHISCENCE ZONE POLYGALACTURONASE1 (ADPG1) ADPG2 were previously shown to be essential silique dehiscence Arabidopsis (Arabidopsis thaliana). Here, we demonstrate that gene CELLULASE6 (CEL6) MANNANASE7 (MAN7) function of siliques. We found genes expressed both vegetative...
In this study, we synthesised the zinc oxide nanoparticles from Vernonia amygdalina and evaluated its anti-inflammatory antinociceptive potentials against different inflammation pain induced mice model. The were characterised by UV, SEM, XRD FTIR techniques. anti-nociceptive effects of V. examined stimuli e.g. acetic acid, glutamate, capsaicin, formalin-induced nociception in mice. assessed air sack assessment level inflammatory cytokines studied. muscle tension animals studied through open...
Isoflurane, a widely used volatile anesthetic, induces neuronal apoptosis and memory impairments in various animal models. However, the potential mechanisms effective pharmacologic agents are still not fully understood. The p38MAPK/ATF-2 pathway has been proved to regulate cell survival inflammation. Besides, atorvastatin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, exerts neuroprotective effects. Thus, this study aimed explore influence of atorvastatin on isoflurane-induced...
Men with prediabetes often exhibit concomitant low-quality sperm production or even infertility, problems which urgently require improved therapeutic options. In this study, we have established a sheep model of diet-induced that is associated spermatogenic defects and explored the possible underlying metabolic causes.We compared male fed normal diet those in was induced by rich third group supplemented melatonin. Only had symptoms prediabetes, these sheep, found impaired spermatogenesis...
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Retrotransposons are the most abundant group of transposable elements (TEs) in plants, providing an extraordinarily versatile source genetic variation. Thlaspi arvense, a close relative model plant Arabidopsis thaliana with worldwide distribution, thrives from sea level to above 4,000 m elevation Qinghai-Tibet Plateau (QTP), China. Its strong adaptability renders it ideal system for studying adaptation extreme environments. However, how retrotransposons affect T. arvense genome evolution and...
Multilineage-differentiating stress-enduring (Muse) cells, a cell subgroup from mesenchymal stem cells (MSCs), are pluripotent with unique characteristics such as non-tumorigenic and differentiation ability. After homing, Muse spontaneously differentiate into tissue component supplement damaged/lost to participate in repair. Importantly, can survive injured for an extended period, stabilizing promoting In addition, it has been confirmed that injection of exogenous exerts anti-inflammatory,...
Spermatogenesis is a highly coordinated and complex process, pivotal for transmitting genetic information between mammalian generations. In this study, we investigated the conservation, differences, biological functions of homologous genes during spermatogenesis in Mongolia sheep, humans, cynomolgus monkey, mice using single-cell RNA sequencing technology. We compared X chromosome meiotic inactivation events to uncover concerted activity genes. Subsequently, focused on dynamics gene...
Abstract Orphan genes are genetic innovations that lack homologs in other lineages. can rapidly originate and become substantially functional, yet the mechanisms underlying their origins still largely unknown plants. Here, we investigated origin of orphan Oryza sativa ssp. japonica “Nipponbare” genome using genome‐wide comparisons with 10 closely related species. We identified a total 37 Nipponbare show short sequence lengths, elevated GC content, absence introns. Interestingly, half...
We investigated antitumor activity and underlying mechanisms of DNA topoisomerase I (TopI) inhibitor gimatecan irinotecan in gastric cancer (GC) vitro cell lines vivo patient-derived xenograft (PDX) models. GC SNU-1, HGC27, MGC803 NCI-N87 were used to evaluate viability apoptosis after or treatment, using a proliferation assay flow cytometry, respectively. TopI expression critical molecules PI3K/AKT, MAPK signaling pathways analyzed with western blot. For studies, five PDXs models treated...
In clinic, perioperative neurocognitive disorder is becoming a common complication of surgery in old patients. Neuroinflammation and blood–brain barrier (BBB) disruption are important contributors for cognitive impairment. Atorvastatin, as strong HMG-CoA reductase inhibitor, has been widely used clinic. However, it remains unclear whether atorvastatin could prevent anesthesia surgery-induced BBB injury by its anti-inflammatory property. this study, aged C57BL/6J mice were to address...
As an important horticultural plant, Rhododendron is often used in urban greening and landscape design. However, factors such as the high rate of genetic recombination, frequent outcrossing wild, weak linkage disequilibrium, susceptibility gene expression to environmental limit further exploration functional genes related traits, make breeding new varieties require a longer time. Therefore, we choose bark target trait which not easily affected by factors, but also has ornamental properties....
Multilineage-differentiating stress-enduring (Muse) cells are a type of pluripotent cell with unique characteristics such as non-tumorigenic and differentiation ability. After homing, Muse spontaneously differentiate into tissue component supplement damaged/lost to participate in repair. Importantly, can survive injured for an extended period, stabilizing promoting In addition, it has been confirmed that injection exogenous exerts anti-inflammatory, anti-apoptosis, anti-fibrosis,...
Quantitative reverse transcription PCR (qRT-PCR) is a sensitive technique used in gene expression studies. To achieve reliable quantification of transcripts, appropriate reference genes are required for comparison transcripts different samples. However, few available non-model taxa, and to date, Cycas elongata have not been well characterized. In this study, 13 (ACT7, TUB, UBQ, EIF4, EF1, CLATHRIN1, PP2A, RPB2, GAPC2, TIP41, MAPK, SAMDC CYP) were chosen from the transcriptome database C....
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. HCC patients suffer from a high mortality-to-incidence ratio and low cure rate since we still have no specific effective treatment. Although tremendous advances been made in investigation of HCC, mechanisms progression this disease are only partially established. Hence, more research needed to elucidate underlying potential develop strategies for HCC.To determine role developing brain homeobox 2 (Dbx2) gene promoting...