A5101924797- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Pneumonia and Respiratory Infections
- Neuroscience of respiration and sleep
- Genetic factors in colorectal cancer
- Prion Diseases and Protein Misfolding
- Peptidase Inhibition and Analysis
- Lung Cancer Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Fungal Infections and Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Mycobacterium research and diagnosis
- Sepsis Diagnosis and Treatment
- Actinomycetales infections and treatment
- Genetic Associations and Epidemiology
- Central Venous Catheters and Hemodialysis
- Cardiovascular and Diving-Related Complications
- Metallurgy and Material Science
- Infectious Disease Case Reports and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Neurological diseases and metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Hydrogen's biological and therapeutic effects
- Nicotinic Acetylcholine Receptors Study
Shanghai Public Health Clinical Center
2022-2025
Capital Medical University
2016-2024
Beijing Shijitan Hospital
2016-2024
Peking University
2021-2023
Jintan People's Hospital
2023
Jiangsu University
2023
First Hospital of China Medical University
2021-2023
China Medical University
2021-2023
Capital University
2023
Jinan University
2023
Abstract Genome-wide association studies (GWASs) have identified multiple susceptibility loci for colorectal cancer, but much of heritability remains unexplained. To identify additional here we perform a GWAS in 1,023 cases and 1,306 controls replicate the findings seven independent samples from China, comprising 5,317 6,887 controls. We find variant at 12p13.2 associated with cancer risk (rs2238126 ETV6, P =2.67 × 10 −10 ). this an 1,046 1,076 European ancestry ( =0.034). The G allele...
Acute lung injury (ALI) as a serious diseases with high mortality and is considered threat to human health life. A number of studies have focused on the treatment prevention injury. However, molecular mechanisms responsible for development are not yet fully understood, this has impeded effective drugs strategies. Hence, in present study, mice lipopolysaccharide (LPS)‑induced ALI were used model investigate crosstalk between CX3CL1-CX3CR1 axis nuclear factor (NF)-κB signaling pathway process...
Sivelestat sodium, an inhibitor of neutrophil elastase, was broadly used in the treatment severe pneumonia. However, pharmacokinetic (PK) characteristics sivelestat patients with pneumonia were still unknown. To understand PK for optimizing dose Chinese In this study, we enrolled 15 participants who received 300-500 mg every 24 h infusion duration 5 to 14 days. Blood samples 48 collected and separated plasma drug concentration detection by ultra-high-performance liquid chromatography/tandem...
Tertiary lymphoid structures (TLSs) are found in a variety of malignancies and affect the growth tumors, but few studies have addressed their role lung adenocarcinoma (LAC). We aimed to evaluate clinical features associated with TLSs patients LAC. A collection resected pulmonary nodules LAC was retrospectively analyzed. were quantified by number per square millimeter tumor area (density) degree lymphocyte aggregation (maturity) each case. The correlation between TLS density maturity...
It is well known that scrapie a fatal, neurodegenerative disease in sheep and goat, which belongs to the group of transmissible spongiform encephalopathies (TSEs) or prion diseases. has been confirmed polymorphisms protein gene (PRNP) at codons 136, 154, 171 have strong relationship with sheep. In present study, nine PRNP other six loci (at 101, 112, 127, 137, 138, 152) were detected 180 Chinese Hu All alleles identified resulted three new genotypes. The frequencies predominant 85% (A136),...
Cognitive impairment is an important complication of obstructive sleep apnea (OSA). Chronic intermittent hypoxia (CIH), the main pathophysiological characteristics OSA, closely related to cognitive dysfunction and may be mediated by alpha-7 nicotinic acetylcholine receptors (α7nAChR). This study investigated effects clarified mechanisms α7nAChR on function mice with CIH.Thirty CD-1 were randomly divided into room air (RA), CIH-2 weeks (CIH2W), CIH-4 (CIH4W) groups. was evaluated novel object...
Abstract Background Disseminated nocardiosis is liable to be misdiagnosed owing the non-specific clinical manifestations and laboratory/imaging findings. Metagenomic next-generation sequencing (mNGS) a culture-independent rapid method for direct identification of all microorganisms in specimens. Case presentation A 72-year-old man was admitted our hospital on February 20, 2019 with history recurrent cough, expectoration, fever, diarrhea since 1 month, unconsciousness week. Contrast-enhanced...
Osteoporosis is a prevalent condition among postmenopausal women, and lacks satisfactory therapeutic options. Hydrogen (H2) has been shown to be effective in alleviating many diseases. This study aimed investigate the effects of H2 on inhibiting osteoclastogenesis bone loss ovariectomized mice.Osteoclast differentiation from Raw264.7 cells was induced with receptor activator NF-κB ligand (RANKL) or without 60% H2. The number resorption activity osteocalsts were assessed by tartrate-resistant...
In recent years, clinical cases of Chlamydia psittaci pneumonia have gradually increased. can quickly progress to severe pneumonia, leading respiratory failure. cannot be detected by commonly used detection methods, difficulties in diagnosis and treatment, which may eventually develop into pneumonia. Therefore, we should improve our diagnostic treatment capabilities for this disease. This article retrospectively studied 61 from 12 different provinces China, classified them non-severe Divided...
To investigate the status of anti-tuberculosis treatment in critically ill patients, and to explore value APACHE-II score guiding treatment.This analysis included patients with tuberculosis. The utility for predicting drug withdrawal was evaluated using receiver operating characteristic (ROC) curve analysis.Among 320 enrolled (58 ± 22 years; 256 males), 147 (45.9%) had drugs withdrawn. group higher (median [interquartile range]: 21 [3-52] vs. 17 [4-42] points), CD4%, lower hemoglobin level,...
Obstructive sleep apnea (OSA) is a common clinical condition with far-reaching health implications. We aimed to analyze the published articles of OSA and compare differences in aspects years, countries, institutions, journals, authors keywords evaluate hotspots development trends research.We screened all associated literature on from Web Science (WoS) during 2011-2020 analyzed research this field using VOS viewer online bibliometric analysis platform. The BICOMB gCLUTO softwares were used...
Abstract Introduction: Nosocomial Enterococcus faecium ( E ) infections are common among immunocompromised patients; however, sepsis caused by is rarely encountered in the clinical setting. Patient concerns: A 69-year-old woman with a previous history of tuberculosis (TB), developed symptoms recurrent fever, paroxysmal cough, and exertional dyspnea for over 2 months before she presented to hospital. Diagnosis: The patient was initially misdiagnosed TB, did not respond anti-TB therapy....
Disseminated infection caused by Nocardia farcinica with primary nephrotic syndrome is exceedingly rare. A 66-year-old female visited the outpatient department due to fever and fatigue who had been diagnosed as membranous nephropathy a long-term prednisone immunosuppressive therapy. After lung biopsy for many times, culture from space-occupying lesion of right species identification mass spectrometry-based methods (MALDI-TOF) revealed farcinica. By imaging examination, lesions lungs, brain,...
Azoles were used as the primary antifungal agents to treat Cryptococcus gattii infection. Evidence showed that subtypes of C. respond differently azoles, but mechanism is largely elusive. In this study, we aimed find mechanisms differences in azole drug susceptibility different gattii. Eight clinical strains collected for molecular typing, multilocus sequence typing (MLST) analysis, and testing. Based on differences, RNA sequencing data analyzed candidate genes, qPCR validation was...
Acute respiratory distress syndrome (ARDS) is still associated with significant mortality, especially the elderly and those comorbidities are at highest risk of death. Neuromuscular blocking agents (NMBAs) used in a large but highly variable proportion patients ARDS. We describe case one critically ill patient serious ARDS, because virus pneumonia. In spite reduced tidal volume to 4–6 mL/kg predicted body weight (PBW) prone position were applied timely, irresistible progress disease leaded...
AbstractAbstractHere we report a novel β-globin gene mutation in the promoter (HBB:c.-139_-138delAC) detected by next-generation sequencing (NGS). The proband was 28-year-old Chinese male, living Shenzhen City, Guangdong Province, who originates from Hunan Province. red cell indices were almost normal, with slightly decreased Red Cell volume Distribution Width(RDW). Capillary electrophoresis (CE) showed Hb A (93.1%) value below while A2 (4.2%) and F (2.7%) values both beyond normal. set of...