A5100428342- Glycosylation and Glycoproteins Research
- Carbohydrate Chemistry and Synthesis
- Reproductive Biology and Fertility
- Natural product bioactivities and synthesis
- Mathematical and Theoretical Epidemiology and Ecology Models
- Cell Adhesion Molecules Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Evolution and Genetic Dynamics
- Galectins and Cancer Biology
- Tissue Engineering and Regenerative Medicine
- Ovarian function and disorders
- Malaria Research and Control
- Immunotherapy and Immune Responses
- Connective tissue disorders research
- Parasites and Host Interactions
- Research on Leishmaniasis Studies
- Histone Deacetylase Inhibitors Research
- Advanced Differential Equations and Dynamical Systems
- Evolutionary Game Theory and Cooperation
- Cellular Mechanics and Interactions
- Metallurgy and Material Science
- NF-κB Signaling Pathways
- Protein Degradation and Inhibitors
- Complement system in diseases
- Assisted Reproductive Technology and Twin Pregnancy
University of Iowa
2002-2024
Capital Normal University
2021-2023
Lanzhou City University
2023
China Agricultural University
2023
Central South University
2008-2022
Tongji Hospital
2022
Huazhong University of Science and Technology
2010-2022
Second Xiangya Hospital of Central South University
2008-2022
Shandong University
2022
Guangdong Academy of Medical Sciences
2022
Using gene-targeting methods, a progesterone receptor Cre knockin (PR-Cre) mouse was generated in which recombinase inserted into exon 1 of the PR gene. The insertion positions gene downstream (and under specific control) endogenous promoter. As for heterozygotes knockout (PRKO) mutation, mice heterozygous are phenotypically indistinguishable from wildtype. Crossing PR-Cre with ROSA26R reporter revealed that excision activity is restricted to cells express progesterone-responsive tissues...
Polycystic ovary syndrome (PCOS) is typically characterized by a polycystic ovarian morphology, hyperandrogenism, ovulatory dysfunction, and infertility. Furthermore, PCOS patients undergoing stimulation have more oocytes; however, the poor quality of oocytes leads to lower fertilization implantation rates, decreased pregnancy increased miscarriage rates. The complex molecular mechanisms underlying remain be elucidated. We obtained matched cumulus cells (CCs) from patients, compared them...
Although platinum compounds are the first-line treatment for ovarian cancer, majority of patients relapse and develop resistance to treatment. However, mechanism underlying is unclear. The goal our study decipher by which a metabolic kinase, diacylglycerol kinase alpha (DGKA), confers in cancer.Metabolic RNAi synthetic lethal screening was used identify cisplatin driver cancer. DGKA variants were demonstrate need activity resistance. Phospho-proteomic genomic screens performed downstream...
The M2 splice isoform of pyruvate kinase (PKM2) is a key enzyme for generating and ATP in the glycolytic pathway, whereas role PKM2 tumorigenesis remains subject debate. In our study, we found highly expressed melanoma patients malignance positively correlated with high activity capability cells. Suppression expression by knocking down markedly attenuated malignant phenotype both vitro vivo, restoration depleted cells could rescue proliferation, invasion metastasis. With data indicating as...
In this paper, a Beddington–DeAngelis prey–predator model with fear effect, refuge and harvesting is investigated. First, the positivity of solutions boundedness system are given. Then, existence local stability equilibria such obtained. Next, not only different codimension-one bifurcations, as saddle-node bifurcation, transcritical bifurcation Hopf take place, but also Bogdanov–Takens codimension-two occurs predicted by center manifold theorem theory. Finally, some numerical simulations...
O-linked N-acetylglucosamine (O-GlcNAc) glycosylation, a prevalent protein post-translational modification (PTM) that occurs intracellularly, has been shown to crosstalk with phosphorylation and ubiquitination. However, it is unclear whether interplays other PTMs. Here we studied its relationship ADP-ribosylation, which involves decorating target proteins the ADP-ribose moiety. We discovered poly(ADP-ribosyl)ation "eraser", glycohydrolase (PARG), O-GlcNAcylated at Ser26, in close proximity...
Some patients with Plasmodium falciparum infections develop cerebral malaria, acute respiratory distress, and shock ultimately die even though drug therapy has eliminated the parasite from blood, suggesting that a systemic inflammatory response contributes to malarial pathogenesis. berghei-infected mice are well-recognized model of severe malaria (experimental [ESM]), infected exhibit response. Because platelets proposed contribute ESM other responses, we determined whether platelet...
In this article, a delayed phytoplankton-zooplankton system with Allee effect and linear harvesting is proposed, where phytoplankton species protects themselves from zooplankton by producing toxin taking shelter. First, the existence stability of possible equilibria are explored. Next, Hopf bifurcation investigated when has no time delay. What's more, limit cycle demonstrated calculating first Lyapunov number. Then, condition that occurs obtained delay describing maturation period as...
It is well known that scrapie a fatal, neurodegenerative disease in sheep and goat, which belongs to the group of transmissible spongiform encephalopathies (TSEs) or prion diseases. has been confirmed polymorphisms protein gene (PRNP) at codons 136, 154, 171 have strong relationship with sheep. In present study, nine PRNP other six loci (at 101, 112, 127, 137, 138, 152) were detected 180 Chinese Hu All alleles identified resulted three new genotypes. The frequencies predominant 85% (A136),...
TRAF6, a well-known adapter molecule, plays pivotal role in TLR/IL-1R associated signaling pathway. Although TRAF6 has been shown to have oncogenic activity various malignant tumors, the details remain unclear. In this study, we demonstrated that facilitates Ras (G12V) and EGF-induced cellular transformation through EGFR. Silencing of expression significantly downregulated AP-1 activity, as well MMP-2,9 after EGF stimulation. Furthermore, found an essential cutaneous squamous cell carcinoma...
Abstract We performed a molecular epidemiologic survey of mutations associated with drug-resistance genes in Plasmodium falciparum northeastern Myanmar. In this region, 3 highly mutated haplotypes and 1 decreased quinine susceptibility were prevalent, which suggests that parasites may be resistant to multiple commonly used antimalarial drugs.
Plasmodium berghei-infected mice, a well-recognized model of experimental cerebral malaria (ECM), exhibit many the hallmarks systemic inflammatory response, with organ damage in brain, lung, and kidneys. Identification molecules mediating pathogenesis such as leukocyte adhesion, may lead to new therapies. Indeed, mice lacking cell adhesion molecule P-selectin were significantly (P = 0.005) protected from death due P. berghei compared C57BL/6 controls despite similar parasitemia 0.6) being...
Huang, J.; Xu, Gao, S.; Lian, X., and Li, J., 2015. Analysis of influence on the Bohai Sea tidal system induced by coastline modification.Four identical hydrodynamic simulation experiments for have been implemented respectively with MIKE31 model based four different coastlines 2000, 2008, 2010, 2012, when intensive usage was carried on. The comparison these is used to present caused modification. analysis shows that semi-diurnal amphidromic point near Yellow River estuary moves towards...
Introduction: A key regulator of collective cell migration is prostaglandin (PG) signaling. However, it remains largely unclear whether PGs act within the migratory cells or their microenvironment to promote migration. Here we use Drosophila border as a model uncover cell-specific roles two in The undergo and invasive between nurse cells; thus, are substrate for cells. Prior work found PG signaling required on-time cluster cohesion. Methods: Confocal microscopy quantitative image analyses...
A differential algebraic nutrient-plankton-fish model with taxation, free fishing zone, protected zone and multiple delays is investigated in this paper. First, the conditions of existence control singularity induced bifurcation are given by regarding economic interest as parameter. Meanwhile, Hopf bifurcations when migration rates, taxation cost per unit harvest taken parameters respectively. Next, local stability interior equilibrium, properties discussed different cases five delays....
Lymphocyte infiltration is an important feature of cancer. There a complex network chemokines that influence the degree and phenotype lymphocyte infiltration, as well growth, survival, migration, angiogenesis tumor cells. High heterogeneity metastasis major obstacle to treatment breast Herein, we showed O-GlcNAcylation B lymphocyte-induced maturation protein-1 (Blimp-1) in lymphocytes inhibited migration invasion cancer It was found Blimp-1 at Ser448 Ser472 promoted its nuclear localization,...
To fully protect the rights of participants in cancer clinical studies and clarify key points for ethics review content informed consent forms process collecting consent, Medical Ethics Professional Committee China Anti-Cancer Association engaged joint discussions with committees well-known hospitals to formulate this consensus, along attached general template studies. This work is expected provide guidance suggestions practice sponsors, researchers, committees.
Schistosome granulomas produce IL-4, important for Th2 granuloma expression. We defined the origins of IL-4 within these and role IL-4-producing CD4(+) T cells in development. Dispersed spontaneously produced independently cells, whereas IL-5 production was cell dependent. Granuloma mRNA localized to non-T cells. NK but not B vitro. cell-/- mice generated that normally. eosinophils expressed no or mRNA. Granulomas WWv mast cell-deficient lacked The dispersed from released only after...
Abstract Background Understanding how genetic polymorphisms are associated with the pathophysiology of major depressive disorder (MDD) may aid in diagnosis and development personalized treatment strategies. CNR1 is gene coding Cannabinoid type 1 receptor which highly involved emotional processing regulating neurotransmitter releases. We aimed to investigate associations single‐nucleotide (SNPs) MDD susceptibility response. Methods The study reported data on 181 Han Chinese 80 healthy...