A5075853957- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Axon Guidance and Neuronal Signaling
- RNA modifications and cancer
- NF-κB Signaling Pathways
- Hippo pathway signaling and YAP/TAZ
- S100 Proteins and Annexins
- Inflammasome and immune disorders
- Autophagy in Disease and Therapy
- Signaling Pathways in Disease
- Head and Neck Cancer Studies
- Immune cells in cancer
- Plant-based Medicinal Research
- Flavonoids in Medical Research
- Ferroptosis and cancer prognosis
- interferon and immune responses
- Cancer Mechanisms and Therapy
- Melanoma and MAPK Pathways
- Synthesis and biological activity
- Dermatologic Treatments and Research
- Cell Adhesion Molecules Research
- Skin Protection and Aging
- RNA regulation and disease
- IL-33, ST2, and ILC Pathways
Xiangya Hospital Central South University
2014-2025
Central South University
2014-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2024
Chinese Academy of Medical Sciences Dermatology Hospital
2019-2024
Academy of Medical Sciences
2019-2023
Creative Commons
2021
Institute of Dermatology
2019
Peking Union Medical College Hospital
2019
Annexin A1 (ANXA1) is dysregulated in the various tumors. However, role and mechanism of ANXA1 cancers are poorly understood. In this study, we first showed a clinically positive correlation between autophagy-associated protein SQSTM1 expression nasopharyngeal carcinoma (NPC) ANXA1-regulating through autophagy, further demonstrated that inhibited BECN1 ATG5-dependent autophagy NPC cells. Using phospho-kinase antibody array to identify signaling which regulated cell found ANXA1-suppressed was...
Abstract Radioresistance poses a major challenge in nasopharyngeal carcinoma (NPC) treatment, but little is known about how miRNA (miR) regulates this phenomenon. In study, we investigated the function and mechanism of miR-203 NPC radioresistance, one downregulated miRs radioresistant cells identified by our previous microarray analysis. We observed that was frequently tissues compared with radiosensitive tissues, its decrement significantly correlated radioresistance poor patient survival,...
MiR-125b is aberrantly expressed and has a role in the various types of tumors. However, mechanism miR-125b nasopharyngeal carcinoma (NPC) are unclear. In this study, we investigated NPC. We observed that was significantly upregulated NPC tissues relative to normal mucosa (NNM), its increment correlated with poor patient survival, an independent predictor for reduced survival; promoted cell proliferation inhibited apoptosis; mouse model, administration antagomir growth xenograft...
Abstract RACK1 is upregulated in the various types of human cancers, and considered to play a role development progression cancer. However, mechanism RACK colon cancer are poorly understood. In this study, we detected expression 63 normal colonic mucosa, 60 inflammatory polyps, adenomas, 180 adenocarcinomas, 40 lymph node metastases by immunohistochemistry, observed that was progressively elevated carcinogenic process epithelium, expressional levels were positively correlated with malignant...
// Jia-Quan Qu 1,2 , Hong-Mei Yi Xu Ye Li-Na Li Jin-Feng Zhu Ta Xiao Yuan Jiao-Yang Yuan-Yuan Wang Juan Feng Qiu-Yan He Shan-Shan Lu Hong and Zhi-Qiang 1 Research Center of Carcinogenesis Targeted Therapy, Xiangya Hospital, Central South University, Changsha, Hunan, China 2 The Higher Educational Key Laboratory for Cancer Proteomics Translational Medicine Hunan Province, Correspondence to: Yi, email: Xiao, Keywords : nasopharyngeal carcinoma, radioresistance, miR-23a, IL-8, Stat3 Received...
Abstract Overexpression of ANXA1 and EphA2 has been linked to various cancers both proteins have attracted considerable attention for the development new anticancer drugs. Here we report that competes with Cbl binding increases its stability by inhibiting Cbl-mediated ubiquitination degradation in nasopharyngeal carcinoma (NPC). Binding promoted NPC cell growth metastasis vitro vivo elevating levels increasing activity oncogenic signaling (pS897-EphA2). Expression was positively correlated...
Abstract Gasdermin E (GSDME)-mediated pyroptosis is induced in keratinocytes of UVB-challenged skin. The role GSDME UVB-caused skin damage remains unknown. To explore the UVB-induced inflammation. We compared differences appearance, histological features, keratinocyte death modalities, infiltration immune cells, and levels some inflammatory cytokines between Gsdme −/− mice wild type (WT) after UVB exposure. explored whether contribute to deficiency-caused aggravation inflammation knockdown...
Raf kinase inhibitory protein (RKIP) functions as a chemo-immunotherapeutic sensitizer of cancers, but regulation RKIP on tumor radiosensitivity remains largely unexplored. In this study, we investigate the role and mechanism in nasopharyngeal carcinoma (NPC) radioresistance. The results showed that was frequently downregulated radioresistant NPC tissues compared with radiosensitive tissues, its reduction correlated radioresistance poor patient survival, an independent prognostic factor....
Abstract Radioresistance poses a major challenge in nasopharyngeal carcinoma (NPC) treatment, but little is known about how miRNA regulates this phenomenon. In study, we investigated the function and mechanism of miR-125b NPC radioresistance, one upregulated miRNAs radioresistant cells identified by our previous microarray analysis. We observed that was frequently NPCs, its increment significantly correlated with an independent predictor for poor patient survival. vitro radioresponse assays...
Abstract HDAC7 plays a crucial role in cancers, and is the main drug target of several HDAC inhibitors. However, mechanism nasopharyngeal carcinoma (NPC) are still unclear. In this study, we observed that was significantly upregulated NPC tissues relative to normal mucosa (NNM) tissues, expression levels were positively correlated with progression negatively patient prognosis, knockdown dramatically inhibited vitro proliferation, migration, invasion cells, growth xenografts mice, indicating...
// Qiu-Yan He 1,2 , Hong-Mei Yi Hong Ta Xiao Jia-Quan Qu Li Yuan Jin-Feng Zhu Jiao-Yang Yuan-Yuan Wang Li-Na Juan Feng Shan-Shan Lu and Zhi-Qiang 1 Research Center of Carcinogenesis Targeted Therapy, Xiangya Hospital, Central South University, Changsha, Hunan, China 2 The Higher Educational Key Laboratory for Cancer Proteomics Translational Medicine Hunan Province, Correspondence to: Xiao, email: Keywords : nasopharyngeal carcinoma; metastasis; RKIP; Stat3; metastatic suppressor Received...
Abstract EphA2 is an important oncogenic protein and emerging drug target, but the role mechanism of ligand-independent phosphorylation at tyrosine 772 (pY772-EphA2) unclear. In this study, we established nasopharyngeal carcinoma (NPC) cell lines with stable expression exogenous EphA2-Y772A (phosphorylation inactivation) using endogenous EphA2-knockdown cells, observed that pY772A was responsible for EphA2-promoting NPC proliferation anchorage-independent in vivo growth mice....
TRAF6, a well-known adapter molecule, plays pivotal role in TLR/IL-1R associated signaling pathway. Although TRAF6 has been shown to have oncogenic activity various malignant tumors, the details remain unclear. In this study, we demonstrated that facilitates Ras (G12V) and EGF-induced cellular transformation through EGFR. Silencing of expression significantly downregulated AP-1 activity, as well MMP-2,9 after EGF stimulation. Furthermore, found an essential cutaneous squamous cell carcinoma...
Abstract Background Malignant transformation of the epidermis is an essential process in pathogenesis cutaneous squamous-cell carcinoma (cSCC). Although evidence has demonstrated that CD147 plays key roles various tumors, role epidermal malignant vivo remains unclear. Methods Epidermal CD147-overexpression or knockout (Epi CD147-OE Epi CD147-KO ) transgenic mouse models were generated for study. RNA-sequencing and q-PCR performed to identify differentially expressed genes....
Keratinocyte necroptosis (with proinflammatory characteristic) is required for epidermal damage in contact hypersensitivity (CHS). In DNCB-induced CHS mice model, we observed the aggravated keratinocyte death and increased phosphorylation level of MLKL, RIPK3 RIPK1. However, skin lesion did not present keratinocyte-specific Mlkl knockout mice. We validated that MLKL-mediated response to immune microenvironment CHS. Moreover, deficiency or inhibition resulted blocking recruitment activation...
Radioresistance poses a major challenge in nasopharyngeal carcinoma (NPC) treatment. Clinical tumor-node-metastasis (TNM) staging has limited accuracy predicting NPC radioresponse and determining its therapeutic regimens. To construct risk score model for radioresistance, immunohistochemistry was used to assess the expression of four proteins (14-3-3σ, Maspin, RKIP, GRP78) 149 samples with different radiosensitivity. Sequentially, logistic regression analysis performed identify independent...