A5112579016- Viral Infections and Immunology Research
- interferon and immune responses
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Viral gastroenteritis research and epidemiology
- RNA regulation and disease
- Inflammasome and immune disorders
- Cytomegalovirus and herpesvirus research
- Circular RNAs in diseases
- Virus-based gene therapy research
- Herpesvirus Infections and Treatments
- RNA modifications and cancer
- Immune Response and Inflammation
- Autophagy in Disease and Therapy
- Animal Disease Management and Epidemiology
- Respiratory viral infections research
- MicroRNA in disease regulation
- Molecular Biology Techniques and Applications
- Escherichia coli research studies
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- ATP Synthase and ATPases Research
- Genetic Neurodegenerative Diseases
- NF-κB Signaling Pathways
- Ferroptosis and cancer prognosis
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Hebei Medical University
2025
Pediatrics and Genetics
2025
Sun Yat-sen University
2023-2024
Fifth Affiliated Hospital of Sun Yat-sen University
2023-2024
Chinese People's Liberation Army
2024
Qingdao University
2017-2024
Affiliated Hospital of Qingdao University
2017-2024
Harbin Veterinary Research Institute
2023-2024
Xinxiang Medical University
2023-2024
Coxsackievirus A16 (CA16) is a member of the Picornaviridae family and causes mild self-limiting hand, foot, mouth disease (HFMD) in infants young children. CA16 infection can also progress to central nervous system (CNS) complications; however, underlying mechanism by which penetrates blood-brain barrier (BBB) then CNS damage remains unclear. This study aimed explore neurotropic tropism establishing an vitro BBB model with vivo rhesus monkey infant model. The results showed that induced...
Acute myeloid leukemia (AML) shows significant heterogeneity in therapeutic responses. We aimed to develop a gene signature for the stratification of high-risk pediatric AML using publicly available datasets, with focus on literature-based prognostic sets. identified 300 genes from 12 well-validated studies AML-related signatures. Clinical and expression data were obtained three datasets: TCGA-LAML, TARGET-AML, BeatAML. Least absolute shrinkage selection operator (LASSO)-Cox regression...
Circulating immune cells and metabolites are linked to coronary atherosclerosis, but the specific causal relationships role of as mediators remain unclear. Summary statistics from GWAS datasets on (n=3,757), circulating (n=8,299), atherosclerosis (cases n=51,589; controls n=343,079) were analyzed using bidirectional Mendelian randomization. Two-step multivariate randomization employed identify mediating metabolites, with inverse variance weighting (IVW) primary method. We identified nine...
Toll-like receptors (TLRs) act as molecular sentinels, detecting invading viral pathogens and triggering host innate immune responses, including autophagy. However, many viruses have evolved a series of strategies to manipulate autophagy for their own benefit. Enterovirus 71 (EV71) coxsackievirus A16 (CA16), the primary agents causing hand, foot mouth disease (HFMD), can induce leading replication. Therefore, objective this study was investigate whether enhanced replication caused by in EV71...
Study Design. Finite element analysis. Objective. To investigate the biomechanical effect of four posterior fixation techniques on stability and adjacent segment degeneration in treating thoracolumbar burst fractures with osteoporosis. Summary Background Data. In terms degeneration, there remains no consensus or guidelines optimal technique for treatment patients Materials Methods. Images CT scans were imported into MIMICS further processed by Geomagic to build three-dimensional models...
Data from EV-D68-infected patients demonstrate that pathological changes in the lower respiratory tract are principally characterized by severe illness children and acute flaccid myelitis. However, lack of a suitable animal model for EV-D68 infection has limited study on pathogenesis this critical pathogen, development vaccine. Ferrets have been widely used to evaluate virus infections. In current study, we ferrets as potential identify impersonal indices, involving clinical features...
Enterovirus 71 (EV-A71) and coxsackievirus A16 (CV-A16) remain the predominant etiological agents of hand, foot, mouth disease (HFMD). The clinical manifestations caused by two viruses are obviously different. CV-A16 usually triggers a repeated infection, airway epithelial integrity is often potential causative factor respiratory infections. Our previous studies have demonstrated that there were some differentially expressed miRNAs involved in regulation adhesion function barrier EV-A71 In...
Dental erosion is a chemical-mechanical process that leads to the loss of dental hard tissues. This study aimed investigate effect pomegranate juice on enamel.
Purpose: Oxidative stress promotes disease progression by stimulating the humoral and cellular immune responses. However, molecular mechanisms underlying oxidative responses in acute pancreatitis (AP) have not been extensively studied. Patients Methods: We analyzed GSE194331 dataset stress-related genes (OSRGs). identified differentially expressed cell-associated OSRGs (DE-ICA-OSRGs) overlapping key module from weighted gene co-expression network analysis, OSRGs, DEGs between AP normal...
Enterovirus 71 (EV71) and Coxsackievirus A16 (CA16) remain the predominant pathogens in hand, foot, mouth disease (HFMD), but factors underlying pathogenesis of EV71 CA16 infections have not been elucidated. Recently, functions microRNAs (miRNAs) pathogen-host interactions highlighted. In present study, we performed comprehensive miRNA profiling EV71- CA16-infected human umbilical vein endothelial cells (HUVECs) at multiple time points using high-throughput sequencing. The results showed...
Enterovirus 71 (EV71) and Coxsackievirus A16 (CA16) are the predominant pathogens of hand, foot, mouth disease (HFMD). Although these viruses exhibit genetic homology, clinical manifestations caused by two have some discrepancies. In addition, underlying mechanisms leading to differences remain unclear. microRNAs (miRNAs) participate in numerous biological or pathological processes, including host responses viral infections. Here, we focused on miRNA expression patterns rhesus monkey...
The role of mitochondrial dysfunction and its molecular mechanism in inflammation-induced acute liver failure (ALF) remain unknown. Despite the numerous studies performed to date, very few therapies are available for ALF. Therefore, our study is aimed explore regulatory effects stress Akt-Sirt3 pathway on development TNF-α-induced hepatocyte death assess therapeutic melatonin damaged liver. Our results exhibited that TNF-α treatment induced damage vitro; effect which was dose-dependently...
Coxsackievirus A10 (CV-A10) has been one of the main etiologies hand, foot, and mouth disease (HFMD) epidemics in recent years can cause mild to severe illness even death. Most these fatal cases were closely associated with neurological impairments, but potential mechanism neuropathological injury triggered by CV-A10 infection not elucidated. MicroRNAs (miRNAs), implicated regulation gene expression a post-transcriptional manner, play vital role pathogenesis various central nervous system...
Hypoxia is prognostically important in colorectal cancer (CRC) therapy. Partial oxygen pressure (pO 2 ) an parameter of hypoxia. The correlation between pO levels and expression prognostic biomarkers was measured CRC tissues. Human tissues were collected by OxyLite. Three methods for tissue fixation compared, including formalin, Finefix, Finefix‐plus‐microwave. Immunohistochemistry (IHC) staining conducted using the avidin‐biotin complex technique detecting antibodies to hypoxia inducible...
Hand, foot, and mouth disease (HFMD) mainly caused by Enterovirus 71 (EV71) coxsackievirus A16 (CA16) infections which presented significantly different clinical manifestations. Nevertheless, the factors underlying these differences remain unclear. Recently, functions of microRNAs (miRNAs) in pathogen-host interactions have been highlighted. Here, we performed comprehensive miRNA profiling EV71- CA16-infected human bronchial epithelial (16HBE) cells at multiple time points using...
Enterovirus D68 (EV-D68) belongs to the picornavirus family and was first isolated in CA, USA, 1962. EV-D68 can cause severe cranial nerve system damage such as flaccid paralysis acute respiratory diseases pneumonia. There are currently no efficient therapeutic methods or effective prophylactics. In this study, we mAb A6-1 from an EV-D68-infected rhesus macaque (Macaca mulatta) found that Ab provided protection intranasally infected suckling mice. We observed bound DE loop of VP1 interfered...
Effective therapy for hepatocellular carcinoma (HCC) is currently an imperative issue, and sorafenib a first-line drug the treatment of HCC. However, clinical benefit often impaired by resistance. Accordingly, present study was conducted to investigate molecular mechanisms involving resistance, with focus on large tumor suppressor 2 (LATS2) mitophagy.HepG2 liver cancer cells were treated infected adenovirus-loaded LATS2 (Ad-LATS2). Cell death, proliferation migration measured via western...
The COVID-19 pandemic has caused changes in urban mobility patterns due to the temporary movement restrictive policies imposed by local governments and long-term hybrid work arrangements adapted companies. This study re-examines fundamental theories of human Singapore at pre-pandemic, endemic stages. In particular, we estimated three well-established models complexity science: gravity model, radiation model visitation law for investigating effects different stages, using transit...