A5010132737- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Injury Epidemiology and Prevention
- Pelvic and Acetabular Injuries
- Medical Imaging and Analysis
- RNA modifications and cancer
- Magnesium Alloys: Properties and Applications
- Bone Tissue Engineering Materials
- Autopsy Techniques and Outcomes
- Musculoskeletal pain and rehabilitation
- Autophagy in Disease and Therapy
- Extracellular vesicles in disease
- Robot Manipulation and Learning
- Trauma Management and Diagnosis
- Dental Radiography and Imaging
- Cancer-related molecular mechanisms research
- Nanoplatforms for cancer theranostics
- Forensic Entomology and Diptera Studies
- Cancer-related gene regulation
- Osteoarthritis Treatment and Mechanisms
- Tendon Structure and Treatment
- Polymer Surface Interaction Studies
- Neuroscience of respiration and sleep
- Cervical and Thoracic Myelopathy
- Fire Detection and Safety Systems
Qingdao University
2020-2024
Affiliated Hospital of Qingdao University
2020-2024
Southwest University of Science and Technology
2023-2024
Southern Medical University
2022-2023
Shengli Oilfield Central Hospital
2023
Memorial Hospital of South Bend
1995
Chang Gung Memorial Hospital
1994-1995
The reconstruction of the vascular network is crucial step in bone regeneration. Therefore, effectively modulating angiogenesis-osteogenesis coupling tissue engineering scaffolds currently an urgent need. In this study, we employed silane agents containing double bonds to modify tetrahedral silicate, resulting preparation a photocurable precursor 45S5 bioactive glass (PG). PG was utilized as binding agent for tricalcium phosphate (TCP) powder, and one-step photocuring 3D printing approach...
A prospective study was conducted to quantitatively measure the relative muscle torque strengths in 20 consecutive women with unilateral osteoarthritic hips and men osteonecrotic before after primary cementless total hip arthroplasty. Maximal isometric muscles of flexion, extension, abduction around joint were measured preoperatively postoperatively at six months one year, using a Cybex 340 dynamometer. The results showed improved function arthroplasty both diseased healthy hips. In hips,...
A novel antibacterial Mg-Al-Ga layered double hydroxide (LDH) coating was fabricated on micro-arc oxide (MAO) coated magnesium (Mg) alloy AZ31 via low-temperature water bath treatment. Electrochemical polarization and impedance spectroscopy, hydrogen evolution rates, pH monitoring tests were used to characterize the degradation behaviors. The morphology, compositions, microstructures of samples investigated using scanning electron microscopy, energy-dispersive X-ray Fourier transform...
Study Design. Finite element analysis. Objective. To investigate the biomechanical effect of four posterior fixation techniques on stability and adjacent segment degeneration in treating thoracolumbar burst fractures with osteoporosis. Summary Background Data. In terms degeneration, there remains no consensus or guidelines optimal technique for treatment patients Materials Methods. Images CT scans were imported into MIMICS further processed by Geomagic to build three-dimensional models...
1.Abstract Key pathological factors contributing to intervertebral disc degeneration (IVDD) include excessive production of reactive oxygen species (ROS), depletion the extracellular matrix (ECM), and an imbalance in M1/M2 macrophage ratio. To address these challenges, we developed a novel bioactive hydrogel (FUH@dECM) by integrating high-concentration fucoidan (FU) with decellularized (dECM). This is designed for situ injection, where it undergoes gelation at site administration,...
Automatic spine and vertebra segmentation from X-ray images is a critical challenging problem in many computer-aid spinal image analysis disease diagnosis applications. In this paper, two-stage automatic framework for proposed, which can firstly locate the regions (including backbone, sacrum ilium) coarse stage then identify eighteen vertebrae (i.e., cervical 7, thoracic 1-12 lumbar 1-5) with isolate clear boundary fine stage. A novel Attention Gate based dual-pathway Network (AGNet)...
Percutaneous endoscopic lumbar discectomy has been widely used in clinical practice for spine diseases. But the postoperative disc re-herniation and inflammation are main reason pain recurrence after surgery. The local defect of intervertebral will lead to instability spine, further aggravating process degeneration. In this work, we successfully synthesized thermosensitive injectable celecoxib-loaded chitosan hydrogel investigated its material properties, repair effect, biocompatibility,...
Abstract Background Disc degeneration is associated with repetitive violent injuries. This study aims to explore the impact of strikes loading on biology and biomechanics intervertebral discs (IVDs) using an organ culture model. Methods IVDs from bovine tail were isolated cultured in a bioreactor, exposure various conditions. The control group was subjected physiological loading, while model exposed either one strike (compression at 38% IVD height) or height). height dynamic compressive...
The diatom test is a forensic technique that can provide supportive evidence in the diagnosis of drowning but requires laborious observation and counting diatoms using microscopy with too much effort, therefore it promising to introduce artificial intelligence (AI) make process automatic. In this article, we propose an solution based on YOLOv5 framework for automatic detection recognition genera. To evaluate performance AI different scenarios, collected five lab-grown genera samples some...
To evaluate the clinical outcome of manual reduction combined with pedicle fixation through Wiltse paraspinal approach (WPA) in treatment thoracolumbar fractures.From May 2017 to 2019, 48 fractures patients without neurological symptoms were enrolled this study. Forty-eight randomly divided into two groups based on different surgical treatment. Group 1 was screw group. 2 traditional posterior The operation time (OT), intraoperative blood loss (BL), postoperative drainage (PD), brace (TB) and...
Abstract Purpose This study aimed to establish a nomogram predict the risk of venous thromboembolism (VTE), identifying potential factors, and providing theoretical basis for prevention VTE after spinal surgery. Methods A retrospective analysis was conducted on 2754 patients who underwent The general characteristics training group were initially screened using univariate logistic analysis, LASSO method used optimal prediction. Subsequently, multivariate regression performed identify...
Osteosarcoma is the most common primary and highly invasive bone tumor in children adolescents. The purpose of this study to construct a multi-gene expression feature related autophagy, which can be used predict prognosis patients with osteosarcoma. Materials methods. clinical gene data osteosarcoma were obtained from target database. Enrichment analysis autophagy-related genes overall survival (OS-related ARGs) screened by univariate Cox regression was determine OS-related ARGs function...
Objective Atlantoaxial dislocation patients with neurological defects require surgery. Sometimes, release surgery is necessary for irreducible atlantoaxial to further achieve reduction. Whether essential relies on the surgeon's experience and lacks objective reference criteria. To evaluate value of joint inclination angle (AAJI) in sagittal coronal planes reduction index (RI) surgical approach selection dislocation. Methods Retrospectively analyzed 87 cases (42 males 45 females, 9–89 years)...
Despite advancements in medical imaging technology, the diagnosis and positioning of lumbar disc diseases still heavily rely on expertise experience professionals. This process is often time-consuming, labor-intensive, susceptible to subjective factors. Achieving automatic segmentation intervertebral (LID) first critical step intelligent diseases. However, due complexity vertebral body ambiguity soft tissue boundaries LID, accurate LIDs remains challenging. The study aims accurately...
Objective: To investigate the biomechanical characteristics of different posterior fixation techniques in treatment osteoporotic thoracolumbar burst fractures by finite element analysis. Methods: The Dicom format images T10-L5 segments were obtained from CT scanning a volunteer, and transferred to Geomagic Studio software, which was used build digital models. L1 fracture simulated SolidWorks software. data ROM, maximum displacement fixed segment, ROM fractured vertebrae, stress on screws...
Increasing evidence indicates that alternative polyadenylation (APA) is associated with the prognosis of cancers. We obtained gene expression and APA profiles 259 sarcoma patients from TCGA dataportal TC3A database, respectively. The prognostic signatures, clinical nomograms, regulatory networks were studied by integrated bioinformatics analyses. Then, immune cell infiltration profile was ImmuCellAI. association between APA-based signature cells studied. A total 61 38 events identified as...
Spinal epidural abscess (SEA) is an uncommon clinical entity that often subject to delayed diagnosis and suboptimal treatment. Untreated disease leads compression of the spinal cord, resulting in devastating complications.A 56-year-old man visited our hospital for progressive lower back extremity pain several days' duration. Significant pyrexia (39.5°C) elevated C-reactive protein (89.2 mg/L) were detected during admission, but no positive neurological examination findings observed. Magnetic...
Abstract Background Atlantoaxial subluxation (AAS) is a not rare abnormality between the atlas (C1) and axis (C2). For AAS patients with persistent neck pain neurologic symptoms, surgical intervention good choice. Nevertheless, there were still few reports about use of intraoperative skull traction different fixation methods in treatment AAS. Methods From January 2012 to December 2018, total 86 cases admitted our hospital diagnosed as All received atlantoaxial reduction help C1-C2 fixation....