A5101684745- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Advanced Neuroimaging Techniques and Applications
- Neurobiology of Language and Bilingualism
- Immune Response and Inflammation
- Clinical Reasoning and Diagnostic Skills
- Cerebrovascular and Carotid Artery Diseases
- Innovations in Medical Education
- Acupuncture Treatment Research Studies
- Autophagy in Disease and Therapy
- Histone Deacetylase Inhibitors Research
- Bioinformatics and Genomic Networks
- Gut microbiota and health
- vaccines and immunoinformatics approaches
- Neuroendocrine Tumor Research Advances
- Heart Rate Variability and Autonomic Control
- Pain Management and Placebo Effect
- Cardiovascular Health and Disease Prevention
- Spinal Fractures and Fixation Techniques
- Pancreatic and Hepatic Oncology Research
- Scoliosis diagnosis and treatment
- Sepsis Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Long-Term Effects of COVID-19
Beijing University of Chinese Medicine
2021-2024
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2021-2022
Sichuan University
2021-2022
Zhongnan Hospital of Wuhan University
2022
Wuhan University
2020-2022
West China Hospital of Sichuan University
2021-2022
Huazhong University of Science and Technology
2019
Central Hospital of Wuhan
2019
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2019
Pancreatic ductal adenocarcinoma (PDAC) is characterized by the highest mortality among carcinomas. The pathogenesis of PDAC requires elevated autophagy, inhibition which using hydroxychloroquine has shown promise. However, current realization impeded its suboptimal use and unpredictable toxicity. Attempts to identify novel autophagy-modulating agents from already approved drugs offer a rapid accessible approach. Here, patient-derived organoid model, we performed comparative analysis...
COVID-19 is a respiratory disease caused by severe acute syndrome coronavirus 2 (SARS-CoV-2). The pandemic has posed serious threat to global health and the economy, so it necessary find safe effective antibody drugs treatments.
Enterovirus D68 (EV-D68) belongs to the picornavirus family and was first isolated in CA, USA, 1962. EV-D68 can cause severe cranial nerve system damage such as flaccid paralysis acute respiratory diseases pneumonia. There are currently no efficient therapeutic methods or effective prophylactics. In this study, we mAb A6-1 from an EV-D68-infected rhesus macaque (Macaca mulatta) found that Ab provided protection intranasally infected suckling mice. We observed bound DE loop of VP1 interfered...
Introduction Post-stroke aphasia (PSA) is a language disorder caused by left hemisphere stroke. Electroacupuncture (EA) minimally invasive therapeutic option for PSA treatment. Tongli (HT5) and Xuanzhong (GB39), two important language-associated acupoints, are frequently used in the rehabilitation of patients with PSA. Preliminary evidence indicated functional activation distributed cortical areas upon HT5 GB39 stimulation. However, research on modulation dynamic static connectivity (FC)...
The gut microbiome is closely associated with the health of host; although interaction between bacterial and whole virome has rarely been studied, it likely medical importance. Examination interactions rhesus monkey would significantly contribute to revealing composition. Here, we conducted a metagenomic analysis monkeys in longitudinal cohort treated an antibiotic cocktail, documented virome. depletion viral populations was confirmed at species level by real-time PCR. We also detected...
Abstract Objective This study aimed to explore the association of JKAP with sepsis risk and investigate its correlation disease severity, inflammatory cytokines, survival in patients. Methods A hundred one patients along 100 healthy controls were enrolled, their blood serum samples collected for cytokines measurement by enzyme‐linked immunoassay. The difference between was determined. Among patients, laboratory indexes, 28‐day mortality, accumulating analyzed. Results JNK pathway–associated...
Presently, the omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) dominates amid disease 2019 (COVID-19) pandemic, but its clinical characteristics with intrinsic severity and organ tropism remain understudied.
Background: Since December 2019, novel coronavirus (2019-nCoV)-infected pneumonia (NCP) occurred in Wuhan, and rapidly spread throughout China. We aimed to clarify the characteristics clinical significance of peripheral lymphocyte subset alteration NCP. Methods: The levels subsets were measured by flow cytometry 60 NCP patients before after treatment, their association with efficacy was analyzed. Findings: Compared healthy controls, had a significant decrease total lymphocytes, CD4+ T cells,...
Poststroke aphasia (PSA) is a disabling condition that decreases the quality of life, and duration disease harms life PSA patients. Acupuncture has been widely employed for PSA. There some evidence immediate treatment efficacy acupuncture PSA; however, long-term results after may be poorer.This multicentre, randomized, blinded, nonacupoint (NA) controlled, multimodal neuroimaging clinical trial. A total 48 subjects with subacute will randomly assigned to an acupoint group or NA control...
The role of the right hemisphere (RH) in post-stroke aphasia (PSA) has not been completely understood. In general, language alterations PSA are normally evaluated from perspective processing models developed Western languages such as English. However, successful application for assessing Chinese-language functions patients with reported. this study, features specific language-related lesion distribution and early variations structure RH Chinese were investigated. Forty-two aphasic (female:...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel virus belonging to the Coronaviridae family that causes disease (COVID-19). This rapidly reached pandemic status, presenting serious threat global health. However, detailed molecular mechanism contributing COVID-19 has not yet been elucidated.The expression profiles, including mRNA levels, of samples from patients infected with SARS-CoV-2 along clinical data were obtained GSE152075 dataset in Gene Expression Omnibus...
<title>Abstract</title> Background: In China, investigations into the efficacy of neurological clinical teaching try to ascertain impacts various methods on intervention outcomes. However, these studies often suffer from limited sample sizes, single-center and low quality, compounded by lack direct comparative analyses between methods, thereby leaving identification most effective method unresolved. This study aims compare effectiveness in standardized training Chinese neurology clinicians...