A5001971501- Enzyme Catalysis and Immobilization
- Microbial Metabolic Engineering and Bioproduction
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Pain Management
- Alzheimer's disease research and treatments
- Cancer-related molecular mechanisms research
- Pluripotent Stem Cells Research
- Traditional Chinese Medicine Analysis
- Neuroscience and Neuropharmacology Research
- Phagocytosis and Immune Regulation
- Mitochondrial Function and Pathology
- Nuclear physics research studies
- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Cardiac, Anesthesia and Surgical Outcomes
- Neurological Disease Mechanisms and Treatments
- Heat shock proteins research
- Enhanced Recovery After Surgery
- Bone and Dental Protein Studies
- Nuclear Physics and Applications
- Healthcare and Venom Research
- Signaling Pathways in Disease
- Nausea and vomiting management
- solar cell performance optimization
- Genomics, phytochemicals, and oxidative stress
Qingdao University
2013-2022
Affiliated Hospital of Qingdao University
2014-2022
Beijing Forestry University
2022
Guangdong University of Technology
2020-2021
Hubei University of Medicine
2019
Shandong Provincial Hospital
2019
Shandong University
2019
Chinese Academy of Sciences
2013-2018
Shanghai Institute of Applied Physics
2017-2018
University of Chinese Academy of Sciences
2015-2017
Dexmedetomidine (DEX) has been reported to attenuate the ischemia and reperfusion (I/R) induced cardiomyocyte apoptosis. However, mechanisms underlying these protective effect remain be fully elucidated. Cardiomyocyte apoptosis is associated with ischemic heart disease. Here we investigated role of DEX in I/R -induced Mice H9c2 cells were subjected injury hypoxia/reoxygenation (H/R) injury, respectively. The roles on mice exposured H/R or explored. results showed that attenuates...
J. Neurochem. (2011) 119 , 805–814. Abstract The principal active constituent of the botanical drug candidate PBI‐05204, a supercritical CO 2 extract Nerium oleander is cardiac glycoside oleandrin. PBI‐05204 shows potent anticancer activity and currently in phase I clinical trial as treatment for patients with solid tumors. We have previously shown that neriifolin, which structurally related to oleandrin, provides robust neuroprotection brain slice whole animal models ischemic injury....
This study aims to investigate the role of targeting lncRNA myocardial infarction-associated transcript (MIAT) in protection against hypoxia/reoxygenation (H/R) injury H9c2 cells vitro and ischemia/reperfusion (I/R) vivo by regulating expression NF-kB p53 upregulated modulator apoptosis (PUMA). H9C2 were infected with lentivirus expressing short-hairpin RNA direct human MIAT gene (Lv-MIAT shRNA) or scrambled control (Lv-NC PUMA siRNA p65 their respectively. Then Lv-shRNA 2 hours hypoxia (H)...
Survivin, an inhibitor of apoptosis, is overexpressed in pancreatic ductal adenocarcinoma (PDAC). Its expression known to be associated with poor clinical outcome. However, our knowledge, there has been no study characterize its usefulness as a serum marker for human cancer. Furthermore, the relation between survivin and level not widely studied PDAC. We performed this investigate PDAC significance prognostic factor.We immunohistochemical staining formalin-fixed, paraffin-embedded blocks...
We have previously shown that the botanical drug candidate PBI-05204, a supercritical CO2 extract of Nerium oleander, provides neuroprotection in both vitro and vivo brain slice-based models for focal ischemia (Dunn et al., 2011). Intriguingly, plasma levels neurotrophin BDNF were increased patients treated with PBI-05204 phase I clinical trial (Bidyasar 2009). thus tested hypothesis provided by to rat slices damaged oxygen-glucose deprivation (OGD) is mediated BDNF. found, fact, exogenous...
Glioma is one of the leading causes death worldwide with high incidence, recurrence, and mortality. Interleukin-10 (IL-10) a cytokine dual function in many types tumors. Although IL-10 overexpressed promotes tumor progression human primary brain tumor, mechanisms are largely unknown.Glioma cells were treated different dosages IL-10. The cell growth was detected by CCK-8, invasion measured Transwell. relative expression messenger RNAs quantitative real-time polymerase chain reaction.We found...
Background We compared the effects of thoracic epidural analgesia (TEA) to conventional patient‐controlled (PCA) on several postoperative parameters recovery after elective video‐assisted thoracoscopic (VATS) lobectomy. Methods Ninety‐eight patients undergoing VATS lobectomy were enrolled. The primary endpoint was pain score. Recovery bowel function, length stay in postanesthesia care unit (PACU), duration hospital stay, and complications assessed. Continuous variables expressed between...
Abstract Background Local anesthesia can reduce the response to surgical stress and decrease consumption of opioids, which may immunosuppression potentially delay postoperative tumor recurrence. We compared paravertebral block (PVB) combined with general (GA) regarding their effects on pain matrix metalloproteinase-9 (MMP-9) after video-assisted thoracoscopic surgery (VATS) lobectomy. Methods 54 patients undergoing elective VATS lobectomy at a single tertiary care, teaching hospital located...
Abstract We previously reported neuroprotective activity of the botanical anti-cancer drug candidate PBI-05204, a supercritical CO 2 extract Nerium oleander , in brain slice and vivo models ischemic stroke. showed that one component this is mediated through its principal cardiac glycoside constituent, oleandrin, via induction potent neurotrophic factor brain-derived (BDNF). However, we also noted concentration-relation for PBI-05204 oxygen-glucose deprivation (OGD) model considerably broader...
Protective effect of dexmedetomidine (DEX) on the lungs one‑lung ventilation (OLV) rat model and its inflammatory factors were investigated. Ninety‑two rats selected divided into groups A, B, C D (n=23) according to principle similar body weight. OLV was established. Before modeling (15 min), in group injected with sodium chloride. Rats DEX at a speed 5 µg/kg/h. Group A ventilated both for 2 h. B (0.9% chloride injection + OLV) (DEX subjected h bilateral 10 min. Concentrations interleukin...
Abstract Background Acute kidney injury (AKI) is a common postoperative complication of orthotopic liver transplantation (OLT). So far, little attention has been paid on the association between overweight and AKI after OLT, animal models or clinical studies have drawn conflicting conclusions. The objective our study was to determine whether (BMI [Body Mass Index] ≥ 25 kg/m 2 ) associated with an increased risk OLT. Methods This retrospective cohort included 244 patients receiving OLT in...
Mitochondria play an important role in neuronal apoptosis caused by cerebral ischemia, and the is mediated expression of mitochondrial proteins. This study investigated involvement proteins hippocampal cell after transient ischemia-reperfusion injury aged rats using a comparative proteomics strategy. Our experimental results show that rat brain sensitive to ischemia led hippocampus changes memory cognition rats. Differential analysis suggested this phenomenon may be associated with energy...
A large number of propeptide regions from various proteins have been identified which function as intramolecular chaperones and assist the folding respective functional domains. The same polypeptide can fold into an altered conformation because a mutated chaperone maintain "memory" process (new physicochemical properties). Two new kinds Rhizomucor miehei lipase (RML) were constructed by replacing its region with that either Rhizopus chinensis (RCL) or oryzae (ROL). enzymatic properties also...
The tumor necrosis factor (TNF) and the cellular NF-κB pathway protein IKKβ play important roles in various processes such as cell proliferation, survival, differentiation, apoptosis. A heat shock 90 inhibitor, 17-DMAG, can induce apoptosis of some cells. This study is to determine combined effects 17-DMAG TNF on malignant cells related mechanisms. We have determined an Hsp90 treatments small lung cancer line (MS-1), adenocarcinoma (A549), squamous-cell carcinoma (LK-2), normal human...
Primulina pungentisepala is suitable for use as a potted plant because of its beautiful leaf variegation, which significantly different in selfed offspring. However, the mechanism P. variegation unclear. In this study, two types offspring showing greatest differences were compared terms structure, chlorophyll contents, fluorescence parameters and transcriptomes to provide reference studying molecular structural variegation. Air spaces found between water storage tissue, palisade tissue cells...